Relation between porphyrin-metabolic disorders and some internal factors in lead-exposed subjects

铅暴露人群卟啉代谢紊乱与部分内在因素的关系

• 批准号: 07457096
• 负责人: TOMOKUNI Katsumaro
• 金额: $ 4.67万
• 依托单位: Saga Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457096/
• 关键词: lead workers; porphyrin-metabolic disorder; delta-aminolevulinic acid; sensibility; sex difference; blood lead; ポリフィリン代謝異常; コプロポルフィリン; 血液鉛

To elucidate the relationship between lead-induced porphyrin metabolic disorders and some internal factors, we first investigated whether the response of biological parameters such as plasma delta-aminolevulinic acid (ALA), urinary ALA,and urinary coproporphyrin (CP) differs between male and female workers occupationally exposed to lead.The biological samples (urine and blood) were obtained from about 300 lead workers (160 males and 138 females). The concentrations (mean<plus-minus>SD) of blood lead (males : 55<plus-minus>13 mug/dl ; females : 55<plus-minus>14mug/dl) indicated that the intensity of occupational exposure to lead was almost equal in the two groups. On the other hand, the elevation of plasma ALA concentration and the increased urine ALA and CP excretions among these lead workers were much higher in females than in males. This data confirms the finding of a sex difference in the biological effect of human expSecondly, we determined some biological parameters such as copper, zinc, vitamin E,beta-carotene, and superoxide dismutase (SOD) activity in the blood samples. However, we could not find significant relations between these parameters and the degree of porphyrin metabolic disorders in lead-exposed workers.

为了阐明铅致卟啉代谢紊乱与某些内在因素的关系，我们首先研究了铅致卟啉代谢紊乱的生物学指标如血浆δ-氨基乙酰丙酸（ALA）、尿ALA、尿粪卟啉（CP）在职业接触铅的男女工人之间存在差异。（尿和血）从约300名铅工人（160名男性和138名女性）。血铅浓度（平均<plus-minus>SD）（男性：55 - <plus-minus>13 μ g/dl ;女性：55 <plus-minus>- 14 μ g/dl）表明，职业接触铅的强度在两组中几乎相等。另一方面，女性铅作业者血浆ALA浓度升高及尿ALA和CP排泄量增加均明显高于男性。其次，我们测定了血液样品中的一些生物学参数，如铜、锌、维生素E、β-胡萝卜素和超氧化物歧化酶（SOD）活性。然而，我们没有发现这些参数之间的显着关系卟啉代谢紊乱的程度，铅接触工人。

项目成果

H.Oishi: "Comparison between males and females with respect to the porphyrin metabolic disorders found in workers." Int. Arch.Occup.Environ.Health. 68. 298-304 (1996)

H.Oishi：“关于工人中发现的卟啉代谢紊乱的男性和女性之间的比较。”