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Endocrine cell tumors of gastrointestinal tract : characteristics and histogenesis

胃肠道内分泌细胞肿瘤：特征和组织发生

基本信息

批准号：
06807016
负责人：
IWAFUCHI Mitsuya
金额：
$ 1.22万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06807016/
关键词：
Carcinoid Endocrine cell carcinoma Small cell carcinoma Paraneuroma Gut hormone Cell culture 内分泌細胞腫瘍セロトニン

项目摘要

During the period of past two years of this particular project, endocrine cell tumors of the gastrointestinal tract of Japanese were collected and and alyzed.1. Endocrine cell tumors of the gestrointestinal tract were divided into two groups : carcinoid tumor (CD), low-grade malignancy and endocrine cell carcinoma (ECC), high-grade malignancy. Histological differential diagnosis between these two entities was estab lished.2. CD was suspected to be mainly derived from immature endocrine cells. ECC were hypo thesized to derive from neoplastic endocrine cell in mucosal tubular adenocarcinoma or adenoma, totipotential stem cell, CD,or immature endocrine cell. The first pathway was suspected to be most frequent, followed by the second.3. New classification on CD and ECC according to different ocurring sites was established.4. Difference of p53 protein overexpression and cell proliferation activity between CD and ECC was established. p53 protein overexpression and cell proliferation activity were decreased or lost even in well differentiated ECC cells.5. Four cell lines established from human esophageal, gastric and rectal ECC were examined. revealed a well preservation of hormone (srotonin, peptide YY,calcitonin)-production. Cell line from esophageal ECC was effected by Vincristin and Mitomycin.

在过去两年的时间里，收集和分析了日本人胃肠道的内分泌细胞肿瘤。将胃肠道内分泌细胞瘤分为类癌(CD)、低度恶性和内分泌细胞癌(ECC)、高度恶性两组。建立了这两种实体的组织学鉴别诊断。推测Cd主要来源于未成熟的内分泌细胞。ECC可能来源于粘膜管状腺癌或腺瘤中的肿瘤内分泌细胞、全潜能干细胞、CD或未成熟的内分泌细胞。怀疑第一种途径最常见，其次是第二种途径。根据发病部位的不同，对CD和ECC进行了新的分类。CD和ECC的P53蛋白过表达和细胞增殖活性存在差异。即使在分化较好的ECC细胞中，P53蛋白过表达和细胞增殖活性也降低或丧失。对从人食道、胃和直肠ECC建立的四种细胞系进行了检测。显示了激素(Srotonin、肽YY、降钙素)-产生的良好保存。长春新碱和丝裂霉素对体外培养的人食道ECC细胞株有影响。