权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study on Cerebral Blood Flow, Cerebral Metabolism and Pathological Changes in Cerebral Venous Occlusion

脑静脉阻塞时脑血流、脑代谢及病理变化的研究

基本信息

批准号：
05454401
负责人：
SAKAKI Toshisuke
金额：
$ 3.52万
依托单位：
Nara Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454401/
关键词：
Cerebral vein Sinus thrombosis Venous infarction cerebral vein sinus thrombosis venous infarction cerebral sinus cortical vein cerebral circulation

项目摘要

Research consisted of three studies. The first study is measurement of local cerebral blood flow in cerebral venous occlusion with autoradiography after intravenous injection of C^<14> -iodoantipyrine. The second is the study of serial measurement of extracellular lactate concentration with microdyalysis, and measurement of glucose metabolism using autoradiography after intravenous injection of C^<14> -deoxyglucose. The third study is to investigate the blood-brain barrier disruption and pathological changes of the cerebral vein on surgical occlusion of the cortical vein and brain retraction. In the first and second studies, occlusion of the superior sagittal sinus and cortical veins was performed with intrasinus injection of cyanoacrylate. If the occlusion was localized in the sinus, cerebral blood flow and cerebral glucose metabolism were maintained in the physiological values. If the cortical veins were occluded with retrograde filling of cyanoacrylate, remarkable decreasing of cerebral blood flow, increasing of extracellular lactate and marked disturbance of glucose metabolism occurred in the more extent area than the territories from which blood was washed out by the involved cortical veins. And the third study showed that both loadings of cortical vein occlusion and brain retraction induce remarkable blood-brain barrier disruption secondary to extent venous intimal injuries and intravenous thrombus formation.

研究包括三项研究。第一项研究是静脉注射C 14 -碘安替比林后用放射自显影术测量脑静脉闭塞的局部脑血流量。第二个是用微透析连续测量细胞外乳酸浓度以及静脉注射C 14 -脱氧葡萄糖后使用放射自显影测量葡萄糖代谢的研究。第三项研究是探讨皮质静脉手术闭塞和脑回缩对血脑屏障的破坏和脑静脉的病理变化。在第一项和第二项研究中，通过窦内注射氰基丙烯酸酯来闭塞上矢状窦和皮质静脉。如果闭塞仅限于窦，则脑血流量和脑葡萄糖代谢维持在生理值。如果用氰基丙烯酸酯逆行填充来闭塞皮质静脉，则在比受累皮质静脉冲走血液的区域更广泛的区域，会出现脑血流量显着减少、细胞外乳酸增加和葡萄糖代谢显着紊乱。第三项研究表明，皮质静脉闭塞和大脑回缩的负荷都会引起显着的血脑屏障破坏，继发静脉内膜损伤和静脉血栓形成。