Study on Cerebral Blood Flow, Cerebral Metabolism and Pathological Changes in Cerebral Venous Occlusion

研究包括三项研究。第一项研究是静脉注射C^ -碘安替比林后，用放射自显影术测量脑静脉闭塞的局部脑血流量<14>。第二个是用微量透析法连续测定细胞外乳酸浓度的研究，以及静脉注射C^ -脱氧葡萄糖后用放射自显影法测定葡萄糖代谢的研究<14>。研究三是探讨手术阻断大脑皮质静脉和脑牵开对血脑屏障的破坏及脑静脉的病理变化。在第一项和第二项研究中，通过窦内注射氰基丙烯酸酯闭塞上级矢状窦和皮质静脉。如果闭塞在窦内，脑血流量和脑葡萄糖代谢维持在生理值。如果用氰基丙烯酸酯逆行灌注闭塞皮质静脉，则脑血流量明显减少，细胞外乳酸增加，葡萄糖代谢明显紊乱的范围比被受累皮质静脉冲洗的区域更广。第三项研究表明，皮质静脉阻塞和脑回缩的负荷均引起明显的血脑屏障破坏，继发于静脉内膜损伤和静脉血栓形成。

Research consisted of three studies. The first study is measurement of local cerebral blood flow in cerebral venous occlusion with autoradiography after intravenous injection of C^<14> -iodoantipyrine. The second is the study of serial measurement of extracellular lactate concentration with microdyalysis, and measurement of glucose metabolism using autoradiography after intravenous injection of C^<14> -deoxyglucose. The third study is to investigate the blood-brain barrier disruption and pathological changes of the cerebral vein on surgical occlusion of the cortical vein and brain retraction. In the first and second studies, occlusion of the superior sagittal sinus and cortical veins was performed with intrasinus injection of cyanoacrylate. If the occlusion was localized in the sinus, cerebral blood flow and cerebral glucose metabolism were maintained in the physiological values. If the cortical veins were occluded with retrograde filling of cyanoacrylate, remarkable decreasing of cerebral blood flow, increasing of extracellular lactate and marked disturbance of glucose metabolism occurred in the more extent area than the territories from which blood was washed out by the involved cortical veins. And the third study showed that both loadings of cortical vein occlusion and brain retraction induce remarkable blood-brain barrier disruption secondary to extent venous intimal injuries and intravenous thrombus formation.