Study on Cerebral Blood Flow, Cerebral Metabolism and Pathological Changes in Cerebral Venous Occlusion

研究由三项研究组成。第一项研究是静脉注射安替比林后，用放射自显影测定脑静脉闭塞局部脑血流量。二是微量动力学连续测定细胞外乳酸浓度，静脉注射14-脱氧葡萄糖后用放射自显影测定葡萄糖代谢的研究。第三项研究是研究大脑皮质静脉闭塞和脑后缩手术对血脑屏障的破坏和脑静脉的病理变化。在第一和第二项研究中，上矢状窦和皮质静脉闭塞是通过鼻窦内注射氰基丙烯酸酯进行的。如果闭塞部位在鼻窦，脑血流量和脑葡萄糖代谢维持在生理值。皮质静脉逆行闭塞氰基丙烯酸酯后，脑血流量明显减少，细胞外乳酸升高，糖代谢明显紊乱，较病变皮质静脉排出血的部位明显减少。第三项研究表明，皮质静脉阻断负荷和脑牵拉负荷均可导致严重的静脉内膜损伤和静脉血栓形成，导致血脑屏障的破坏。

Research consisted of three studies. The first study is measurement of local cerebral blood flow in cerebral venous occlusion with autoradiography after intravenous injection of C^<14> -iodoantipyrine. The second is the study of serial measurement of extracellular lactate concentration with microdyalysis, and measurement of glucose metabolism using autoradiography after intravenous injection of C^<14> -deoxyglucose. The third study is to investigate the blood-brain barrier disruption and pathological changes of the cerebral vein on surgical occlusion of the cortical vein and brain retraction. In the first and second studies, occlusion of the superior sagittal sinus and cortical veins was performed with intrasinus injection of cyanoacrylate. If the occlusion was localized in the sinus, cerebral blood flow and cerebral glucose metabolism were maintained in the physiological values. If the cortical veins were occluded with retrograde filling of cyanoacrylate, remarkable decreasing of cerebral blood flow, increasing of extracellular lactate and marked disturbance of glucose metabolism occurred in the more extent area than the territories from which blood was washed out by the involved cortical veins. And the third study showed that both loadings of cortical vein occlusion and brain retraction induce remarkable blood-brain barrier disruption secondary to extent venous intimal injuries and intravenous thrombus formation.