Hemodynamics of chronic venous hypertension in rat

大鼠慢性静脉高压的血流动力学

基本信息

  • 批准号:
    11470296
  • 负责人:
  • 金额:
    $ 4.35万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    1999
  • 资助国家:
    日本
  • 起止时间:
    1999 至 2001
  • 项目状态:
    已结题

项目摘要

We evaluated changes of regional cerebral venous flow (rCBF) and cerebral blood volume (rCBV) in chronic venous hypertension model in rat. Venous hypertension was induced by an end-to-end anastomosis between the right carotid artery and the right external jugular vein.Local CBF (1CBF) and 1CBV at 25 locations were assessed by a modern laser Doppler "scanning" technique at 4 times ; before and after the anastomosis, 2 weeks after, and after the clip of the fistula. The animals were classified two groups ; sham-operated group (n = 6) (the carotid artery occlusion only) and bypass group (n = 10). In the sham group and the left hemisphere of the bypass group, both of rCBF and rCBV didn't change. However, in the right hemisphere rCBV significantly increased 2 weeks after the bypass but recovered after clipping of the fistula (p < 0.05), and rCBF significantly decreased 2 weeks after the bypass but recovered after clipping of the fistula (P < 0.05).In conclusion, the rat model of carotid-jugular arteriovenous fistula is clinically relevant and useful for studing the pathophysiology of chronic venous hypertension. Venous ischemia is a reversible condition which can be improved by appropriate early-stage treatment.
我们评估了大鼠慢性静脉高压模型中局部脑静脉流量(rCBF)和脑血容量(rCBV)的变化。通过右颈动脉和右颈外静脉之间的端对端吻合诱发静脉高压。通过现代激光多普勒“扫描”技术4次评估25个位置的局部CBF(1CBF)和1CBV;吻合前、吻合后、2周后、以及瘘管夹闭后。将动物分为两组;假手术组(n = 6)(仅颈动脉闭塞)和搭桥组(n = 10)。假手术组和绕道组左半球rCBF和rCBV均未发生变化。然而,在右半球,rCBV在搭桥术后2周显着升高,但在夹闭瘘管后恢复(p < 0.05),rCBF在搭桥术后2周显着降低,但在夹闭瘘管后恢复(P < 0.05)。 总之,颈动脉-颈静脉瘘大鼠模型具有临床相关性,可用于研究慢性颈动脉动静脉瘘的病理生理学。 静脉高压。静脉缺血是一种可逆性疾病,可以通过适当的早期治疗来改善。

项目成果

期刊论文数量(62)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
N.Makase: "Novel intraoperative cerebral blood flow monitoring by laser-Doppler scanner"Neurol Med Chir. 42. 1-4 (2002)
N.Makase:“通过激光多普勒扫描仪进行新型术中脑血流监测”Neurol Med Chir。
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    0
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N.Makase: "Clinical study on recurvent intracranial anaurysms"Cereb Vas Dis. 10. 255-260 (2000)
N.Makase:“颅内动脉瘤复发的临床研究”Cereb Vas Dis。
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    0
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H.Nakase: "A scanning technique to measure regional cerebral blood flow and oxyhemoglobin level"Neurosurgery. 48・6. 1335-1342 (2001)
H.Nakase:“测量局部脑血流量和氧合血红蛋白水平的扫描技术” 48・6(2001)。
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    0
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S.Akata: "Chemical preconditioning with 3-nitropropionic acidin gerbil hippocampal slices ; therapeutic window and the participation of adenosine receptor"Exp Neurol. 166. 385-391 (2000)
S.Akata:“用 3-硝基丙酸对沙鼠海马切片进行化学预处理;治疗窗口和腺苷受体的参与”Exp Neurol。
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    0
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H.Nakase: "Clinical study on recurrent intracranial aneurysms."Cerebrovasc Dis. 10. 255-260 (2000)
H.Nakase:“复发性颅内动脉瘤的临床研究。”Cerebrovasc Dis。
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SAKAKI Toshisuke其他文献

SAKAKI Toshisuke的其他文献

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{{ truncateString('SAKAKI Toshisuke', 18)}}的其他基金

Study on the treatment of dural arteriovenous fistula by the inhibition of angiogenic growth factors
抑制血管生成因子治疗硬脑膜动静脉瘘的研究
  • 批准号:
    18390402
  • 财政年份:
    2006
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on the mechanisms responsible for the development and growth of dural arteriovenous fistula
硬脑膜动静脉瘘发生和生长的机制研究
  • 批准号:
    14370444
  • 财政年份:
    2002
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on Pathological Process of Cerebral Venous Circulation Disturbance
脑静脉循环障碍的病理过程研究
  • 批准号:
    07457321
  • 财政年份:
    1995
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on Cerebral Blood Flow, Cerebral Metabolism and Pathological Changes in Cerebral Venous Occlusion
脑静脉阻塞时脑血流、脑代谢及病理变化的研究
  • 批准号:
    05454401
  • 财政年份:
    1993
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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