Hemodynamics of chronic venous hypertension in rat

本研究观察了慢性静脉高压大鼠局部脑静脉血流量（rCBF）和脑血容量（rCBV）的变化。通过右颈动脉与右颈外静脉端端吻合诱导静脉高压，采用现代激光多普勒“扫描”技术在吻合前后、吻合后2周和夹闭瘘后4次测量25个部位的局部CBF（1CBF）和1CBV。将动物分为两组：假手术组（n = 6）（仅阻断颈动脉）和旁路组（n = 10）。假手术组和转流组左半球rCBF和rCBV无明显变化。然而，右半球的rCBV在旁路术后2周显著增加，但在瘘管夹闭后恢复术后2周rCBF明显下降，但在夹闭瘘口后恢复正常（P < 0.05）。大鼠颈动脉-颈动静脉瘘是临床相关的，并有助于研究慢性静脉高压的病理生理学。静脉缺血是一种可逆性疾病，可以通过适当的早期治疗得到改善。

We evaluated changes of regional cerebral venous flow (rCBF) and cerebral blood volume (rCBV) in chronic venous hypertension model in rat. Venous hypertension was induced by an end-to-end anastomosis between the right carotid artery and the right external jugular vein.Local CBF (1CBF) and 1CBV at 25 locations were assessed by a modern laser Doppler "scanning" technique at 4 times ; before and after the anastomosis, 2 weeks after, and after the clip of the fistula. The animals were classified two groups ; sham-operated group (n = 6) (the carotid artery occlusion only) and bypass group (n = 10). In the sham group and the left hemisphere of the bypass group, both of rCBF and rCBV didn't change. However, in the right hemisphere rCBV significantly increased 2 weeks after the bypass but recovered after clipping of the fistula (p < 0.05), and rCBF significantly decreased 2 weeks after the bypass but recovered after clipping of the fistula (P < 0.05).In conclusion, the rat model of carotid-jugular arteriovenous fistula is clinically relevant and useful for studing the pathophysiology of chronic venous hypertension. Venous ischemia is a reversible condition which can be improved by appropriate early-stage treatment.