Study on the treatment of dural arteriovenous fistula by the inhibition of angiogenic growth factors

抑制血管生成因子治疗硬脑膜动静脉瘘的研究

• 批准号: 18390402
• 负责人: SAKAKI Toshisuke
• 金额: $ 10.43万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390402/
• 关键词: 脳硬膜動静脈瘻; 脳虚血; 静脈梗塞; 血管新生因子; 遺伝子治療; 脳腫瘍; 免疫治療; 樹状細胞; 養子免疫療法; インターフェロン; 脳血管障害学; 硬膜動静脈奇形

The precise mechanisms responsible for the development and growth of dural arteriovenous fistula (DAVF) remain unclear, but it has been hypothesized that vascular angiogenic growth factors might be involved in the pathogenesis. Also, it remains unknown that Brain-Derived Neurotrophic Factor (BDNF) effect on regional Cerebral Blood Flow (rCBF) and has neuroprotective effect in cerebral venous ischemia. The present study was undertaken to investigate whether intraventricular BDNF infusion effects on infarct size and suppression of apoptosis in cerebral venous ischemic lesion in a rat 2-vein occlusion (2-VO) model and effect on rCBF. As the results, there were no statistical differences in rCBF between BDNF-treated and control groups. It was found that the mean infarct volumes after 2-VO were significantly smaller in BDNF-treated animals than controls at 2 days (1.49±1.44% v.s.3.66±1.51%, P<0.05) and 7 days (0.93±0.47% v.s. 1.69±0.58%, P<0.05). The number of TUNEL positive cells detected at 2 days after 2-VO was significantly fewer in BDNF-treated animals (17.0±15.1) than controls (39.0±19.6, P<0.05). These results suggest that continuous intraventricular administration of BDNF protects apoptotic change of brain cortex and reduced infarct size without effect on rCBF in rat venous infarction model.

硬脑膜动静脉瘘（DAVF）发生和生长的确切机制尚不清楚，但据推测，血管血管生成生长因子可能参与发病机制。此外，脑源性神经营养因子（BDNF）对局部脑血流量（rCBF）的影响以及对脑静脉缺血的神经保护作用尚不清楚。本研究旨在观察脑室内注射BDNF对大鼠2-VO模型脑静脉缺血损伤的梗死范围、细胞凋亡的抑制作用及对局部脑血流量的影响。结果显示，BDNF处理组和对照组之间的rCBF无统计学差异。结果发现，在2-VO后，BDNF治疗的动物的平均梗死体积在2天（1.49±1.44%）和7天（0.93±0.47%）显著小于对照组（v.s.3.66± 1.51%，P<0.05）。1.69± 0.58%，P<0.05）。2-VO后2d，BDNF组TUNEL阳性细胞数（17.0±15.1）明显少于对照组（39.0±19.6），P<0.05。结果提示，脑室内持续给予BDNF可保护大鼠静脉性脑梗死模型脑皮质的凋亡改变，缩小梗死面积，而对rCBF无影响。

项目成果

VI. 脳血管奇形 脳動静脈奇形 脳動静脈奇形の発見とその対策 (分担執筆)

六、脑血管畸形 脑动静脉畸形 脑动静脉畸形的发现及其对策（合着）

• 发表时间: 2006
• 作者: 川口正一郎;榊寿右
• 通讯作者: 榊寿右

ラット脳静脈梗塞モデルにおけるCeftriaxoneの効果

头孢曲松钠对大鼠脑静脉梗死模型的影响

• 发表时间: 2008
• 作者: 乾登史孝;中瀬裕之;榊寿右;Heimann A.;Alessandri B.;Kempski O.
• 通讯作者: Kempski O.

Prevention of venous problems associated with the neurosurgery

预防与神经外科手术相关的静脉问题

• 发表时间: 2008
• 作者: Nakase H.;Tamura K.;Taiaki R.;Park Y-S.;Hirabayashi H.;Sakaki T
• 通讯作者: Sakaki T

Novel neuroprotective approaches in experimental model of cerebral venous infarction

脑静脉梗塞实验模型的新神经保护方法

• 发表时间: 2007
• 作者: Masasuke;Ohno;Atsushi;Natsume;Toshihiko;Wakabayashi;Jun;Yoshida;Nakase H
• 通讯作者: Nakase H

The relation between intraoperative measurement of CBF and venous infarction

术中CBF测量与静脉梗死的关系

• 发表时间: 2009
• 作者: Horiuchi K.;Nakase H.;Heimann H.;Kempski O.
• 通讯作者: Kempski O.