Study on the treatment of dural arteriovenous fistula by the inhibition of angiogenic growth factors

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The precise mechanisms responsible for the development and growth of dural arteriovenous fistula (DAVF) remain unclear, but it has been hypothesized that vascular angiogenic growth factors might be involved in the pathogenesis. Also, it remains unknown that Brain-Derived Neurotrophic Factor (BDNF) effect on regional Cerebral Blood Flow (rCBF) and has neuroprotective effect in cerebral venous ischemia. The present study was undertaken to investigate whether intraventricular BDNF infusion effects on infarct size and suppression of apoptosis in cerebral venous ischemic lesion in a rat 2-vein occlusion (2-VO) model and effect on rCBF. As the results, there were no statistical differences in rCBF between BDNF-treated and control groups. It was found that the mean infarct volumes after 2-VO were significantly smaller in BDNF-treated animals than controls at 2 days (1.49±1.44% v.s.3.66±1.51%, P<0.05) and 7 days (0.93±0.47% v.s. 1.69±0.58%, P<0.05). The number of TUNEL positive cells detected at 2 days after 2-VO was significantly fewer in BDNF-treated animals (17.0±15.1) than controls (39.0±19.6, P<0.05). These results suggest that continuous intraventricular administration of BDNF protects apoptotic change of brain cortex and reduced infarct size without effect on rCBF in rat venous infarction model.