Physiological Analysis of Oral Functions under Stress Conditions

应激条件下口腔功能的生理分析

• 批准号: 05454500
• 负责人: MORIMOTO Toshifumi
• 金额: $ 4.35万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454500/
• 关键词: STRESS; MASTICATORY MUSCLE; ELECTROMYOGRAPHY; JAW MOVEMENTS; CERVICAL SYMPATHETIC NERVE; JAW-JERK REFLEX; MUSCLE SPINDLE; BLOOD SUPPLY; 頸部交感神経; ストレス環境; ラット; 咀嚼筋筋電図; 咀嚼筋血流; 咬筋

When humans under stressful condition often gnash or clench their teeth simultaneously with strong activation of jaw-closing muscles. This study aims to analyze the effects of stressful conditions and excitation of the cervical sympathetic nerve on activity of the jaw-closing muscles. The masseteric activity of adult male rats were recorded under the chronic and acute conditions. In the former, the following four stressful conditions were tested : 1) in the cold water (4 C) ; 2) immobilization in the narrow tube ; 3) keeping the standing posture and 4) injection of apprehension inducing drug (FG7142). However, no appreciable activity was induced in the masseter muscle.In acute experiments, injection of mustard-oil into the temporomandibular joint was found to induce masseteric activity temporarily, generally less than 5 minutes. On the other hand, stimulation of the cervical sympathetic nerve inhibit the masseteric activity. This inhibition was found to be due to depression of the jaw-jerk reflex by depression of the sensitivity of muscle spindles in the jaw-closing muscles but not by depression of the arterial blood supply to these muscles. This results have been reported in J.Physiol. (Lond.).

当人类处于紧张状态时，通常会同时咬牙或咬紧牙齿，并强烈激活下颌肌。本研究旨在分析应激条件和颈交感神经兴奋对颌肌活动的影响。记录了成年雄性大鼠在慢性和急性条件下的咬咬活动。在前者中，测试了以下四种应激条件：1)在冷水（4℃）中；2)窄管固定；3)保持站立姿势；4)注射恐惧诱导药物（FG7142）。然而，咬肌没有明显的活动。在急性实验中，发现在颞下颌关节注射芥菜油可暂时引起咬肌活动，一般不超过5分钟。另一方面，刺激颈交感神经抑制咬肌活动。这种抑制作用是由于下颌合肌肌梭的敏感性降低，从而抑制了下颌抽搐反射，而不是由于这些肌肉的动脉供血减少。这一结果已在J.Physiol上报道。(Lond)。

项目成果

H.Abekura: "Alteration in the bite force and EMG activity with the vertical dimension in edentulous subjects" Elsevier(in press), (1995)

H.Abekura：“无牙颌受试者的咬合力和肌电图活动随垂直尺寸的变化”Elsevier（出版中），（1995 年）

R.Matsuo: "Inhibitory effect of sympathetic stimulation on activities of masseter muscle spindles and the jaw ierk reflex in rats" J.Physiol.(Lond.). 483. 239-250 (1995)

R.Matsuo：“交感神经刺激对大鼠咬肌纺锤体活动和下颌跳动反射的抑制作用”J.Physiol.（伦敦）。

T.Morimoto, O.Nakamura, K.Ogata, R.Matsuo, T.Inoue, Y.Masuda, J.Mizuno, T.Katoh: "Autoregulation of masticatory force during fictive mastication in the rabbit." "Brain and Oral Function", eds.Morimoto T.Matsuya T.Takada K.Elsevier, Amsterdam. (in press).

T.Morimoto、O.Nakamura、K.Ogata、R.Matsuo、T.Inoue、Y.Masuda、J.Mizuno、T.Katoh：“兔子虚构咀嚼过程中咀嚼力的自动调节。”

T.Inoue, M.Kobayashi, R.Matsuo, Y.Masuda, O.Nakamura, S.Wakisaka, T.Morimoto: "Faciliation of trigeminal motoneuron excitability by serotonin in the rat." Brain and Oral Function", eds.Morimoto T.Matsuya T.Takada K.Elsevier, Amsterdam. (in press).

T.Inoue、M.Kobayashi、R.Matsuo、Y.Masuda、O.Nakamura、S.Wakisaka、T.Morimoto：“血清素促进大鼠三叉神经运动神经元兴奋性。”

R.Matsuo, A.Ikehara, T.Nokubi, T.Morimoto: "Inhibitory effect of sympathetic stimulation on activites of masseter muscle spindles and the jaw jerk reflex in rats." J.Physiol. 483. 239-250 (1995)

R.Matsuo、A.Ikehara、T.Nokubi、T.Morimoto：“交感神经刺激对大鼠咬肌纺锤体活动和下颌反射的抑制作用。”