Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism R01DE026771

睡眠磨牙症中的情绪失调和睡眠时间咀嚼肌活动 R01DE026771

基本信息

  • 批准号:
    10425898
  • 负责人:
  • 金额:
    $ 7.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-07-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The overall goal of this proposal is to examine the role of emotion regulation (ER) in sleep bruxism (SB). SB is characterized by extreme levels of masticatory muscle activity (MMA) during sleep, expressed as teeth grinding or clenching. SB may proximally lead to tooth damage, orofacial pain, and impaired sleep; predispose to the development of joint degenerative disorders; and ultimately present a preclinical sign for a broader range of neurodegenerative disorders. However, there is as yet no curative treatment for SB, and the mechanisms underlying SB are not well understood. To fill this gap, we propose an integrative neurobiological framework that focuses on the involvement of impaired downregulation of wake-time emotion in SB. We will test basic tenets of this framework by addressing four major aims: Aim 1 tests differences in task-related neural activation during ER in individuals with SB (SB+) vs. matched controls (SB-). Aim 2 investigates direct and indirect pathways associating task- related prefrontal cortex activatin during ER with MMA during sleep among SB+ and SB-. Aim 3 examines whether neural activation during ER can be experimentally manipulated in SB+. Aim 4 addresses causal mechanisms by investigating whether more efficient task-related prefrontal cortex activation during ER decreases MMA during sleep in SB+ through decreased task-related emotional activation of the amygdala. 100 SB+ and 50 SB- will be defined based on polysomnographic research diagnostic criteria. Functional activations of brain regions of interest during an ER task will be assessed and ambulatory monitoring of MMA during sleep will be conducted. In SB+, ER will be experimentally manipulated and effects will be assessed on functional activations of brain regions of interest during the ER task as well as on MMA during sleep. The proposed work is part of a programatic translational research agenda to develop novel effective therapies that target ER processes to alleviate affective, sleep, and stress-induced neurodegenerative disorders.
项目概要 该提案的总体目标是研究情绪调节 (ER) 在睡眠磨牙症中的作用 (SB)。 SB 的特点是睡眠期间咀嚼肌活动 (MMA) 达到极高水平, 表现为磨牙或咬紧牙关。 SB 可能会导致牙齿损伤、口面部疼痛和 睡眠受损;容易发生关节退行性疾病;并最终呈现出一个 更广泛的神经退行性疾病的临床前体征。然而目前还没有 SB 的治疗方法以及 SB 的机制尚不清楚。为了填补这一空白, 我们提出了一个综合神经生物学框架,重点关注受损者的参与 SB 醒来时情绪的下调。我们将通过解决以下问题来测试该框架的基本原则 四个主要目标: 目标 1 测试患有以下疾病的个体在 ER 期间与任务相关的神经激活的差异 SB (SB+) 与匹配对照 (SB-)。目标 2 研究关联任务的直接和间接途径 SB+ 和 SB- 期间 ER 期间的前额皮质激活素与睡眠期间的 MMA 相关。目标 3 检查是否可以在 SB+ 中通过实验操纵 ER 期间的神经激活。目标 4 通过研究是否更有效的任务相关前额皮质来解决因果机制 ER 期间的激活通过减少与任务相关的情绪来减少 SB+ 睡眠期间的 MMA 杏仁核的激活。 100 SB+ 和 50 SB- 将根据多导睡眠图研究定义 诊断标准。将评估 ER 任务期间感兴趣的大脑区域的功能激活 并将在睡眠期间对 MMA 进行动态监测。在 SB+ 中,ER 将进行实验 操纵和影响将评估在该过程中感兴趣的大脑区域的功能激活 ER 任务以及睡眠期间的 MMA 任务。拟议的工作是计划翻译的一部分 研究议程旨在开发针对 ER 过程的新型有效疗法,以减轻情感、 睡眠和压力引起的神经退行性疾病。

项目成果

期刊论文数量(6)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Regulating Road Rage.
Individual differences in perceived sleep quality do not predict negative affect reactivity or regulation.
  • DOI:
    10.1016/j.biopsycho.2021.108149
  • 发表时间:
    2021-09
  • 期刊:
  • 影响因子:
    2.6
  • 作者:
    Zhang J;Ten Brink M;Kreibig SD;Gilam G;Goldin PR;Manber R;Mackey S;Gross JJ
  • 通讯作者:
    Gross JJ
Quantitative versus qualitative emotion regulation goals: Differential effects on emotional responses.
定量与定性情绪调节目标:对情绪反应的不同影响。
  • DOI:
    10.1111/psyp.14387
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Kreibig,SylviaD;Brown,AlanS;Gross,JamesJ
  • 通讯作者:
    Gross,JamesJ
Understanding Mixed Emotions: Paradigms and Measures.
The Role of Emotion Regulation, Affect, and Sleep in Individuals With Sleep Bruxism and Those Without: Protocol for a Remote Longitudinal Observational Study.
  • DOI:
    10.2196/41719
  • 发表时间:
    2023-08-24
  • 期刊:
  • 影响因子:
    1.7
  • 作者:
    Kreibig, Sylvia D.;ten Brink, Maia;Mehta, Ashish;Talmon, Anat;Zhang, Jin-Xiao;Brown, Alan S.;Lucas-Griffin, Sawyer S.;Axelrod, Ariel K.;Manber, Rachel;Lavigne, Gilles J.;Gross, James J.
  • 通讯作者:
    Gross, James J.
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JAMES J GROSS其他文献

JAMES J GROSS的其他文献

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{{ truncateString('JAMES J GROSS', 18)}}的其他基金

Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism
睡眠磨牙症中的情绪失调和睡眠时咀嚼肌活动
  • 批准号:
    10174913
  • 财政年份:
    2017
  • 资助金额:
    $ 7.61万
  • 项目类别:
Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism
睡眠磨牙症中的情绪失调和睡眠时咀嚼肌活动
  • 批准号:
    9905405
  • 财政年份:
    2017
  • 资助金额:
    $ 7.61万
  • 项目类别:
Emotion Dysregulation and Sleep-Time Masticatory Muscle Activity in Sleep Bruxism
睡眠磨牙症中的情绪失调和睡眠时咀嚼肌活动
  • 批准号:
    9287723
  • 财政年份:
    2017
  • 资助金额:
    $ 7.61万
  • 项目类别:
Temporal Dynamics and Neural Bases of Emotion Regulation Under Emotional Load
情绪负荷下情绪调节的时间动力学和神经基础
  • 批准号:
    8463036
  • 财政年份:
    2012
  • 资助金额:
    $ 7.61万
  • 项目类别:
Temporal Dynamics and Neural Bases of Emotion Regulation Under Emotional Load
情绪负荷下情绪调节的时间动力学和神经基础
  • 批准号:
    8302743
  • 财政年份:
    2012
  • 资助金额:
    $ 7.61万
  • 项目类别:
fMRI of Emotion Regulation During RCT of CBT vs. MBSR for Social Anxiety Disorder
CBT 与 MBSR 治疗社交焦虑症的随机对照试验期间情绪调节的功能磁共振成像 (fMRI)
  • 批准号:
    8449242
  • 财政年份:
    2011
  • 资助金额:
    $ 7.61万
  • 项目类别:
fMRI of Emotion Regulation During RCT of CBT vs. MBSR for Social Anxiety Disorder
CBT 与 MBSR 治疗社交焦虑症的随机对照试验期间情绪调节的功能磁共振成像 (fMRI)
  • 批准号:
    8026354
  • 财政年份:
    2011
  • 资助金额:
    $ 7.61万
  • 项目类别:
fMRI of Emotion Regulation During RCT of CBT vs. MBSR for Social Anxiety Disorder
CBT 与 MBSR 治疗社交焦虑症的随机对照试验期间情绪调节的功能磁共振成像 (fMRI)
  • 批准号:
    8814277
  • 财政年份:
    2011
  • 资助金额:
    $ 7.61万
  • 项目类别:
fMRI of Emotion Regulation During RCT of CBT vs. MBSR for Social Anxiety Disorder
CBT 与 MBSR 治疗社交焦虑症的随机对照试验期间情绪调节的功能磁共振成像 (fMRI)
  • 批准号:
    8616094
  • 财政年份:
    2011
  • 资助金额:
    $ 7.61万
  • 项目类别:
fMRI of Emotion Regulation During RCT of CBT vs. MBSR for Social Anxiety Disorder
CBT 与 MBSR 治疗社交焦虑症的随机对照试验期间情绪调节的功能磁共振成像 (fMRI)
  • 批准号:
    8204604
  • 财政年份:
    2011
  • 资助金额:
    $ 7.61万
  • 项目类别:

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