Automated storage and documentation system for protein crystallography ("crystal hotel")

蛋白质晶体学自动存储和文档系统（“水晶酒店”）

• 批准号: 431770762
• 金额: --
• 依托单位: Universität Münster
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/431770762?language=en
• 关键词: Automated; storage; documentation; system; protein

The determination of protein structures is an important method in biomedical research to understand the function of proteins under physiological and pathological conditions. Protein crystallography is an established method to achieve this, but requires the production of protein crystals. Growing protein crystals is the major challenge in structure determination. It requires testing a large number of different conditions and multiple rounds of optimization to obtain suitable crystals. Modern equipment can help solve this problem by automating (part of) the process. The automated storage and documentation system for protein crystallization described in this application represents such a solution. In addition, the advanced imaging capabilities of the system will allow detecting protein crystals that previously would have remained unrecognized. Therefore, this instrument is an essential basis for successfully conducting protein crystallography projects.

蛋白质结构的测定是生物医学研究中了解蛋白质在生理和病理条件下功能的重要方法。蛋白质晶体学是实现这一目标的既定方法，但需要生产蛋白质晶体。生长蛋白质晶体是结构测定的主要挑战。它需要测试大量不同的条件和多轮优化，以获得合适的晶体。现代设备可以通过自动化（部分）过程来帮助解决这个问题。本应用程序中描述的用于蛋白质结晶的自动存储和文档系统代表了这样一种解决方案。此外，该系统的先进成像能力将允许检测以前无法识别的蛋白质晶体。因此，该仪器是成功进行蛋白质晶体学项目的必要基础。