Investigation of urinary dopamine as a marker of renal function and clinical application to laboratory medicine

尿多巴胺作为肾功能标志物的研究及其在检验医学中的临床应用

基本信息

  • 批准号:
    05454586
  • 负责人:
  • 金额:
    $ 2.3万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 财政年份:
    1993
  • 资助国家:
    日本
  • 起止时间:
    1993 至 1994
  • 项目状态:
    已结题

项目摘要

The origin of dopamine in urine was investigated using rats nephrectomized, denervated the renal nerve and treated with carbidopa, an inhibitor of DOPA decarboxylase. The free dopamine excreted in urine is derived from renal tubular dopamine, which is synthesized at proximal tubules and regulates both natriuresis and diuresis. The conjugated dopamine excreted in urine is derived from renal filtrated dopamine, which is originated from the conjugated dopamine in plasma. As the plasma conjugated dopamine is filtrated at glomerulus, the plasma conjugated dopamine elevates in the patients with impaired renal function. Using these parameters of urinary free dopamine, urinary conjugated dopamine and plasma conjugated dopamine, it is possible to evaluate the renal function. We investigated the usefulness of the urinary level of dopamine as a marker of renal function, especially of tubular activity. We determined the correlations between the urinary level of free dopamine and a number of established markers of renal function in patients with chronic glomerulonephritis and healthy volunteers. The urinary level of free dopamine was negatively correlated with the serum level of creatinine and the urinary levels of alpha1-and beta2-microglobulins, and was positively correlated with urinary level of creatinine, urea nitrogen, potassium and inorganic phosphorus. Findings suggest that the urinary level of dopamine is an index of renal functions and that measurements of the urinary level of free dopamine are useful for evaluating renal impairment.
采用大鼠肾切除、去肾神经支配和多巴脱羧酶抑制剂卡比多巴处理,研究尿中多巴胺的来源。尿中排泄的游离多巴胺来源于肾小管多巴胺,其在近端小管合成并调节尿钠排泄和利尿。尿中排泄的结合多巴胺来源于肾过滤的多巴胺,而肾过滤的多巴胺来源于血浆中的结合多巴胺。由于血浆结合多巴胺在肾小球滤过,肾功能损害患者血浆结合多巴胺升高。利用尿游离多巴胺、尿结合多巴胺和血浆结合多巴胺的这些参数,可以评价肾功能。我们研究了尿多巴胺水平作为肾功能,特别是肾小管活动的标志物的有用性。我们确定了慢性肾小球肾炎患者和健康志愿者尿中游离多巴胺水平与一些已确定的肾功能标志物之间的相关性。尿游离多巴胺水平与血清肌酐水平、尿α 1-和β 2-微球蛋白水平呈负相关,与尿肌酐、尿素氮、钾和无机磷水平呈正相关。研究结果表明,尿多巴胺水平是肾功能的指标,尿游离多巴胺水平的测量是有用的评估肾功能损害。

项目成果

期刊论文数量(46)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Manabu Yoshimura et al.: "Diagnostic significance of dopamine excretion in plasma and urine in patients with adrenal and renal insufficiency,renal transplantation and hypertension21GC01:Hypertens Res" 18(印刷中). (1995)
Manabu Yoshimura 等人:“肾上腺和肾功能不全、肾移植和高血压患者血浆和尿液中多巴胺排泄的诊断意义21GC01:高血压研究”18(出版中)。
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Manabu Yoshimura et al.: "Role of plasma dopamine for regulation of blood pressure in humans. In : Cardiovascular and renal actions of dopamine (ed : P.Soares-Da-Silva)." Oxford : Pergamon press. 121-131 (1993)
Manabu Yoshimura 等人:“血浆多巴胺在人类血压调节中的作用。见:多巴胺的心血管和肾脏作用(编辑:P.Soares-Da-Silva)。”
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    0
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Mnabu Yoshimura et al.: "Decreased urinary excretion of free dopamine in patients with renal insufficency"
Mnabu Yoshimura 等人:“肾功能不全患者尿中游离多巴胺排泄减少”
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    0
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Manabu Yoshimura et al.: "Diagnostic significance of dopamine excretion in plasma and urine in patients with adrenal and renal insufficiency,renal transplantation and hypertension" Hypertens Res. 18(印刷中). (1995)
Manabu Yoshimura 等人:“肾上腺和肾功能不全、肾移植和高血压患者血浆和尿液中多巴胺排泄的诊断意义”Hypertens Res 18(出版中)。
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    0
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Manabu Yoshimura et al.: "Estimation of sulfoconjugated catecholamine concentrations in plasma by high performance liquid chromatography." Ann Clin Biochem. 30. 135-141 (1993)
Manabu Yoshimura 等人:“通过高效液相色谱法估算血浆中磺基共轭儿茶酚胺浓度。”
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    0
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YOSHIMURA Manabu其他文献

YOSHIMURA Manabu的其他文献

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{{ truncateString('YOSHIMURA Manabu', 18)}}的其他基金

REASSESSMENT OF DUCTILITY INDEX AND RESIDUAL AXIAL LOAD CAPACITY FOR "SHORT SHEAR COLUMN" AND "SHEAR COLUMN" OF R/C BUILDINGS
遥控建筑“短剪力柱”和“剪力柱”延性指标和残余轴向承载力的重新评估
  • 批准号:
    21360269
  • 财政年份:
    2009
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Improvement of Seismic Performance Evaluation for Existing RC Structures with Brittle Behavior
现有脆性钢筋混凝土结构抗震性能评估的改进
  • 批准号:
    18360268
  • 财政年份:
    2006
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Intermediate-story Collapse of Reinforced Concrete Building Structures
钢筋混凝土建筑结构中层倒塌
  • 批准号:
    12650582
  • 财政年份:
    2000
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Studies of HGF as an indicator of sclerotic vascular lesion
HGF作为硬化性血管病变指标的研究
  • 批准号:
    10470517
  • 财政年份:
    1998
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Nonlinear Model of RC Columns Considering Axial Collapse
考虑轴向倒塌的钢筋混凝土柱非线性模型
  • 批准号:
    10650568
  • 财政年份:
    1998
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of renal function test using dopamine and its utility in laboratory
多巴胺肾功能检测的进展及其实验室应用
  • 批准号:
    07457564
  • 财政年份:
    1995
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Hysteresis of RC Columns Subjected to Bilateral Loading
双边荷载作用下钢筋混凝土柱的滞后
  • 批准号:
    07455226
  • 财政年份:
    1995
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Estimation of plasma dopamine concentration and its clinical significance
血浆多巴胺浓度的估算及其临床意义
  • 批准号:
    03671111
  • 财政年份:
    1991
  • 资助金额:
    $ 2.3万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
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