Studies of HGF as an indicator of sclerotic vascular lesion

HGF作为硬化性血管病变指标的研究

• 批准号: 10470517
• 负责人: YOSHIMURA Manabu
• 金额: $ 6.59万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470517/
• 关键词: HGF; Neovascularization; Arteriosclerosis; Atherosclerosis; Diabetic retinopathy; Proliferative retinopathy; Purpura; Marker of lesion; 動脈硬化症; 細動脈硬化症; coronary atherosclerosis; PTCA; restenosis; monocyte; mRNA

To investigate the role of human hepatocyte growth factor (hHGF) in vascular lesions associated with endothelial injury, we measured serum hHGF concentrations in subjects with retinal arteriosclerosis, coronary atherosclerosis, or arteriolitis due to Henoch-Schonlein purpura. Individuals with more advanced grades of retinal arteriosclerosis showed higher serum hHGF concentrations [grade 0, 0.053【minus-plus】0.005 ng/ml (n=68) ; grade 1, 0.144【minus-plus】0.022 ng/ml ( n=21 ; P<0.01vs. Grade 0) ; grade 2, 0.338【minus-plus】0.036 ng/ml ( n=20 ; P<0.01vs. Grade 0 or 1) ; grade 3, 0.526【minus-plus】0.051 ng/ml ( n=9 ; P<0.01vs.grade 0, 1, or 2)]. Patients with active arteriolitis due to Henoch-Schonlein purpura showed higher ( P<0.01) serum hHGF concentrations (0.347【minus-plus】0.038 ng/ml ; n=14) than those in the remission phase (0.097【minus-plus】0.017 ng/ml ; n=19). Mean serum hHGF concentrations were higher in subjects with coronary atherosclerosis than in those without, but a significant overlap in serum hHGF concentrations was found between subjects with and those without coronary atherosclerosis. Serum hHGF may be an indicator of the presence or development of arteriolar lesions.

为了研究人肝细胞生长因子（hHGF）在血管内皮损伤相关病变中的作用，我们测定了视网膜动脉硬化、冠状动脉粥样硬化或过敏性紫癜引起的小动脉炎患者的血清hHGF浓度。视网膜动脉硬化程度越高的患者血清hHGF浓度越高[0级，0.053[-+]0.005 ng/ml（n=68）; 1级，0.144[-+]0.022 ng/ml（n=21 ; P<0.01 vs. 0级）; 2级，0.338[-+]0.036 ng/ml（n=20 ; P<0.01vs. 0级或1级）; 3级，0.526[-+]0.051 ng/ml（n=9 ; P<0.01 vs.0级、1级或2级）]。过敏性紫癜活动性小动脉炎患者血清hHGF浓度（0.347 ± 0.038 ng/ml ; n=14）高于缓解期患者（0.097 ± 0.017 ng/ml; n= 19）（P<0.01）。平均血清hHGF浓度在冠状动脉粥样硬化的受试者高于那些没有，但血清hHGF浓度的显着重叠，发现受试者和那些没有冠状动脉粥样硬化。血清hHGF可能是小动脉病变存在或发展的指标。

项目成果

Masato Nishimura, et al: "Increased serum concentrations of huma hepatocyte growth factor in proliferative diabetic retinopathy"Journal of Clinical Endocrinology & Metabolism. 84. 659-662 (1999)

Masato Nishimura 等人：“增殖性糖尿病视网膜病变中人肝细胞生长因子的血清浓度增加”临床内分泌学杂志

Masato Nishimura, et al.: "Increased serum concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy"Journal of Clinical Endocrinology & Metabolism. 83. 195-198 (1998)

Masato Nishimura 等人：“增殖性糖尿病视网膜病变中人肝细胞生长因子的血清浓度增加”临床内分泌学杂志

Masato Nishimura, et al: "Increased serum concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy"Journal of Clinical Endocrinology & Metabolism. 83. 195-198 (1998)

Masato Nishimura 等人：“增殖性糖尿病视网膜病变中人肝细胞生长因子的血清浓度增加”临床内分泌学杂志

Masato Nishimura, et al.: "Increased vitreous concentrations of human hepatocyte growth factor in proliferative diabetic retinopathy"Journal of Clinical Endocrinology & Metabolism. 84. 659-662 (1999)

Masato Nishimura 等人：“增殖性糖尿病视网膜病变中人肝细胞生长因子的玻璃体浓度增加”临床内分泌学杂志

Masato Nishimura, et al.: "Serum hepatocyte growth factor in possible indicator of vascular lesions." Journal of Clinical Endocrinology & Metabolism. (in press.). (1999)

Masato Nishimura 等人：“血清肝细胞生长因子可能是血管病变的指标。”