Elucidation of the autonomic nervous control of immune organs.
阐明免疫器官的自主神经控制。
基本信息
- 批准号:05454685
- 负责人:
- 金额:$ 4.1万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (B)
- 财政年份:1993
- 资助国家:日本
- 起止时间:1993 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The effects of non-noxious and noxious mechanical stimulation of the skin on cytotoxic activity of splenic natural killer (NK) cells and splenic blood flow were examined in anesthetized rats.Bilateral brushing of the body surface between the lateral chest and hindlimb for 30 min did not significantly influence cytotoxic activity of splenic NK cells, splenic blood flow or splenic sympathetic efferent nerve activity.Bilateral pinching stimulation of the skin of the hindpaws for 30 min reduced cytotoxic activity of splenic NK cells and splenic blood flow to 67 <plus-minus> 8 and 82 <plus-minus> 3% of the control values, respectively.Pinching hindpaws for 30 min increased splenic sympathetic efferent nerve activity ton 143 <plus-minus> 15% of control.Electrical stimulation of the splanchnic nerve produced a decrease in the cytotoxic activity of splenic NK cells and splenic blood flow.The hindpaw pinching-induced suppression of the splenic sympathetic nerve or the spinal cord at the cervical level.These results indicate that the supersession of cytotoxic activity of NK cells and splenic blood flow following noxious pinching stimulation of hindpaws is a supra-spinal reflex response mediated via the splenic sympathetic nerve.On the other hand, pinching of abdomen for 30 min reduced cytotoxic activity of splenic NK cells both in the central nervous system intact and spinalized rats.Therefore, the abdominal stimulation suppressed the NK activity via spinal reflex pa
本文观察了非伤害性和伤害性机械刺激对麻醉大鼠脾NK细胞杀伤活性和脾血流量的影响,结果表明,双侧刷胸至后肢体表30 min对脾NK细胞杀伤活性无明显影响,结果表明,双侧夹捏后爪皮肤30 min可使脾NK细胞杀伤活性和脾血流量分别降低至对照值的<plus-minus>67.8%和82.3%<plus-minus>,而夹捏后爪皮肤30 min可使脾交感传出神经活性增加<plus-minus>143.15%电刺激内脏神经可引起脾NK细胞毒活性和脾血流量的降低,而后爪伤害性捏夹可引起脾交感神经或脊髓的抑制。这些结果表明,后爪伤害性捏夹刺激后NK细胞毒活性和脾血流量的代谢是一种超负性代谢。脊髓反射通过脾交感神经介导,而腹部挤压30 min则可降低中枢神经系统完整和脊髓损伤大鼠脾NK细胞的细胞毒活性,因此腹部刺激可通过脊髓反射抑制NK细胞的活性。
项目成果
期刊论文数量(89)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kimura,A.,Nagai,N.and Sato,A.: "Somatic afferent regulation of cytotoxic activity of splenic natural killer cells in anesthetized rats." Jap.J.Physiol.44. 651-664 (1994)
Kimura,A.、Nagai,N. 和 Sato,A.:“麻醉大鼠脾脏自然杀伤细胞细胞毒性活性的体细胞传入调节。”
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Sato,A.,Sato,Y.and Schmidt,R.F.: "Modulation of somatocardiac sympathetic reflexes mediated by opioid receptors at the spinal and brainstem level." Exp.Brain Res.,. (in press). (1995)
Sato,A.、Sato,Y. 和 Schmidt,R.F.:“脊髓和脑干水平阿片受体介导的躯体心交感神经反射的调节。”
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Sasaki, M. et al.: "Effect of mechanical stimulation of the skin on the external urethral sphincter muscles in anesthetized cats." Jpn. J. Physiol.44. 575-590 (1994)
Sasaki, M. 等人:“皮肤机械刺激对麻醉猫尿道外括约肌的影响。”
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Sato, A. et al.: "Modulation of somatocardiac sympathetic reflexes mediated by opioid receptors at the spinal and brainstem level." Exp. Brain Res.105. 1-6 (1995)
Sato, A. 等人:“脊髓和脑干水平上阿片受体介导的躯体心交感神经反射的调节。”
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Kurosawa, M. et al.: "Somatic afferent regulation of plasma immunoreactive glucagon in anesthetized rats." Jpn. J. Physiol.44. 221-230 (1994)
Kurosawa, M. 等人:“麻醉大鼠血浆免疫反应性胰高血糖素的体细胞传入调节。”
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An quantitative study about international immigrants: On Bangladeshi workers working in Japan
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22530586 - 财政年份:2010
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An Applied Study about Diversified Types of Teleworking
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17530402 - 财政年份:2005
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An Investigation on Diabates Mellitus and hyperlipidemia in Inner Mongolia, China
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11691203 - 财政年份:1999
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Dietary habits and diabetes mellitus - with special reference to carbohydrate in take
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09470111 - 财政年份:1997
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Grant-in-Aid for Scientific Research (B)
A development of a new method for continuous measurement of regional cerebral blood flow and analysis of the regulation of cerebral blood flow in a conscious rat.
开发一种连续测量清醒大鼠局部脑血流并分析脑血流调节的新方法。
- 批准号:
06558111 - 财政年份:1994
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Grant-in-Aid for Developmental Scientific Research (B)
A new health problem due to trichloroethylene - pneumatosis cystoides intestinalis
三氯乙烯引发的新健康问题——肠囊肿积气症
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01480198 - 财政年份:1989
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Regulation of cerebral blood flows by cholinergic fibers originating in the nucleus basalis of Meynert.
源自 Meynert 基底核的胆碱能纤维对脑血流的调节。
- 批准号:
63480102 - 财政年份:1988
- 资助金额:
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