Pathophysiology of hand-arm vibration syndrome and exposure limit for prevention

手臂振动综合征的病理生理学和预防接触限值

• 批准号: 05670350
• 负责人: HARADA Noriaki
• 金额: $ 1.34万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670350/
• 关键词: Vibration exposure guideline; Hand arm vibration syndrome; Raynaud's phenomenon; Circulatory function; Autonomic nervous system; Sympathoadrenal medullary system; Psychological stressors; Prevalence rate; 評容基準; レイノー現象; 知覚障害; 標準化

Vibration exposure guidelines for prevention of the hand arm vibration syndrome are proposed by the International Organization for Standardization (ISO) . The guidelines are based on the latent interval of Raynaud's phenomenon among Caucasians exposed to vibration, however the evidences are not enough.Acute vibration exposure experiment form 8 Hz to 1000 Hz indicated the following results ; circulatory function of fingers exposed increased due to direct effect of vibration and that of the opposite side fingers decreased due to indirect effect via the autonomic nervous system.Acute stress test in hand-arm vibration syndrome patients using urinary catecholamines indicated the sympathoadrenal medullary response to psychological stressors increased especially in hand-arm vibration syndrome patients with Raynaud's phenomenon in higher frequency.Epidemiological investigation in Japanese general population indicated that the prevalence rates were lower than those in Caucasians. Difference of susceptibility to circulatory disturbance between races as well as pathogenesis of Raynaud's phenomenon induced vibration exposure should be considered for vibration exposure guidelines.

国际标准化组织（ISO）提出了预防手臂振动综合征的振动暴露指南。该指南是基于白人在振动暴露中雷诺现象的潜伏期，但证据不足，从8 Hz到1000 Hz的急性振动暴露实验表明：暴露手指的循环功能由于振动的直接作用而增强，而对侧手指的循环功能由于通过自主神经系统的间接作用而降低。在手臂振动综合征患者中，采用尿儿茶酚胺检测表明，交感肾上腺髓质对心理应激的反应增加，尤其是在手臂振动综合征患者中，雷诺现象发生率更高。在制定振动暴露指南时，应考虑种族间对循环障碍易感性的差异以及雷诺现象的发病机制。

项目成果

岩本美江子: "振動障害患者の入院治療による尿中カテコールアミン排泄量の変化" 日本産業衛生学会総会. 36. 489- (1994)

Mieko Iwamoto：“振动障碍患者住院治疗引起的尿儿茶酚胺排泄变化”日本职业健康学会全体会议 36. 489- (1994)。

Harada N: "Autonomic nervous function of hand-arm vibration syndrome patients" ibid. 57. S77-85 (1994)

Harada N：《手臂振动综合征患者的自主神经功能》同上。

岩本美江子,他: "振動障害患者の入院治療による尿中カテコールアシン排泄量変化" 産業医学. 36. S489 (1994)

Mieko Iwamoto 等人：“振动障碍患者住院治疗引起的尿儿茶素排泄变化”职业医学 36. S489 (1994)。

Harada, N.: "Factors influencing vibration sense threshold test and somatosensory evoked responses to electrical stimulation as an objective test" Abstracts of Stockholm Workshop 94 on Hand-arm Vibration Syndrome-Diagnostic and Quantitative Relationships

Harada, N.：“影响振动感觉阈值测试和电刺激体感诱发反应作为客观测试的因素”斯德哥尔摩第 94 届手臂振动综合症研讨会摘要 - 诊断和定量关系

Yamada S,et al: "Prevention,Clinical,and Pathophysiological Research on Vibration Syndrome." Nagoya J Med. 56. 27-41 (1993)

山田 S 等人：“振动综合症的预防、临床和病理生理学研究”。