Study of generalized symptoms of vibration syndrome - Investigation of hypothalamic function using the TRH test -

振动综合症全身症状的研究 - 使用 TRH 测试调查下丘脑功能 -

• 批准号: 62570249
• 负责人: HARADA Noriaki
• 金额: $ 1.02万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62570249/
• 关键词: vibration syndrome; pituitary-thyroid function; autonomic nervous function; cold exposure test; TRH負荷検査; 下垂体-甲状腺機能; 甲状腺機能; 寒冷負荷; カテコールアミン; サイクリックヌクレオチド

For the purpose of investigating the endocrinological functions of the vibration syndrome, the cold exposure test to whole body and the TRH test were performed. Furing the tests, pituitary hormones and thyroid hormones in the blood were measured as well as plasma cyclic AMP and cyclic GMP which are indicators of the autonomic nervous function. The heart rate variation at rest and during deep breathing was also measured as a indicator of the autonomic nervous function. Using the cold exposure test, the subjects of vibration syndrome with and without Raynaud's phenomenon and the age-matched healthy subjects were examined (n=70 for each group). Using the TRH test, the "subjects of vibration syndrome with Raynaud's phenomenon and age-matched healthy subjects were examined (n=10 for each group). As the results, basal level of the parasympathetic nervous system was decreased and the responses of the sympathetic nervous system and the thyroid system to the cold exposure were activated in the vibration syndrome patients. The TRH test indicated that the responses of plasma TSH and prolactine in the vibration syndrome patients were slightly delayed, however the differences from those of the control group were not significant.

为探讨振证的内分泌功能，进行了全身冷暴露试验和TRH试验。在试验过程中，测定了血液中的垂体激素和甲状腺激素，以及反映自主神经功能的血浆环磷酸腺苷和环磷酸鸟苷。还测量了安静时和深呼吸时的心率变化，以此作为自主神经功能的指标。采用冷暴露试验，对有无雷诺现象的振动证患者和年龄匹配的健康人(每组70例)进行检测。用TRH试验对雷诺现象振动综合征患者和年龄匹配的健康人各10例进行检测，结果表明，振动综合征患者副交感神经系统基础水平降低，交感神经系统和甲状腺系统对冷暴露的反应被激活，TRH试验显示振动综合征患者血浆TSH和PRL的反应略有延迟，但与对照组比较差异无统计学意义。

项目成果

Harada.N;Kondo.H.;Kohno.H.;Nakamoto.M.;Kimura.K.: Proceedings of Fifth International Conference on Hand and Arm Vibration. 1989.

Harada.N；Kondo.H.；Kohno.H.；Nakamoto.M.；Kimura.K.：第五届手和手臂振动国际会议论文集。