Study of generalized symptoms of vibration syndrome - Investigation of hypothalamic function using the TRH test -

为探讨振动综合征的内分泌功能，采用全身冷暴露试验和TRH试验。检测血液中垂体激素和甲状腺激素，以及血浆中反映自主神经功能的环AMP和环GMP。静息和深呼吸时的心率变化也被测量为自主神经功能的指标。采用冷暴露试验对有雷诺现象和无雷诺现象的振动综合征受试者和年龄匹配的健康受试者进行检查（每组70人）。采用TRH试验对振动综合征伴雷诺现象者和年龄匹配的健康者进行检测（每组n=10）。结果表明，振动综合征患者副交感神经系统基础水平降低，交感神经系统和甲状腺系统对冷暴露的反应被激活。TRH试验提示振动综合征患者血浆TSH和泌乳素的反应略有延迟，但与对照组差异不显著。

For the purpose of investigating the endocrinological functions of the vibration syndrome, the cold exposure test to whole body and the TRH test were performed. Furing the tests, pituitary hormones and thyroid hormones in the blood were measured as well as plasma cyclic AMP and cyclic GMP which are indicators of the autonomic nervous function. The heart rate variation at rest and during deep breathing was also measured as a indicator of the autonomic nervous function. Using the cold exposure test, the subjects of vibration syndrome with and without Raynaud's phenomenon and the age-matched healthy subjects were examined (n=70 for each group). Using the TRH test, the "subjects of vibration syndrome with Raynaud's phenomenon and age-matched healthy subjects were examined (n=10 for each group). As the results, basal level of the parasympathetic nervous system was decreased and the responses of the sympathetic nervous system and the thyroid system to the cold exposure were activated in the vibration syndrome patients. The TRH test indicated that the responses of plasma TSH and prolactine in the vibration syndrome patients were slightly delayed, however the differences from those of the control group were not significant.