THE ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS IN REGULATION OF CORONARY BLOOD FLOW

本研究的目的是确定三磷酸腺苷敏感钾通道在冠脉血流调节中的作用。实验是在麻醉犬身上进行的。结果如下：1)冠脉基础血流量的调节冠脉内注入格列本脲(一种通道的特异性阻滞剂)可减少冠脉血流量，但不改变动脉压和心率。匹那地尔可预防格列本脲引起的冠脉血流量减少。这项研究发表在《代谢冠脉血管扩张的调节》杂志上。格列本脲可减弱异丙肾上腺素和地诺帕明诱导的冠脉扩张，但不影响硝酸甘油诱导的冠脉扩张。这项研究发表在《Am J Physiol 1994.3)自动调节》上。冠脉内格列本脲抑制冠脉自身调节性冠脉血管扩张。这项研究发表在1993年的《循环研究》杂志上。

The aim of this study was to determine the role of ATP-sensitive potassium channels in regulation of coronary blood flow. Experiments were performed in anesthetized dogs. The results are as follows.1) Regulation of Basal Coronary Blood FlowIntracoronary infusion of glibenclamide (a specific blocker of the channel) decreased coronary blood flow without altering arterial pressure and heart rate. Pretreatment of pinacidil prevented the glibenclamide-induced decreases in coronary blood flow.This study was published in Am J Physiol 1992.2) Regulation of Metabolic Coronary VasodilationGlibenclamide attenuated coroary vasodilation induced by isoproterenol and denopamine, but did not affect coronary vasodilation induced by nitroglycerin.This study was published in Am J Physiol 1994.3) AutoregulationA relationship between coronary blood flow and perfusion pressure was studied. Intracoronary glibenclamide inhibited coronary autoregulatory coronary vasodilation. The response was reproducible during vehicle infusion.This study was published in Circulation Research 1993.