THE ROLE OF ATP-SENSITIVE POTASSIUM CHANNELS IN REGULATION OF CORONARY BLOOD FLOW

ATP 敏感钾通道在冠状动脉血流调节中的作用

• 批准号: 05670619
• 负责人: CHISHAKI Akiko
• 金额: $ 1.34万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670619/
• 关键词: CORONARY BLOOD FLOW; POTASSIUM CHANNEL; K.チャンネル; 冠循環; グリベンクラミド; ATP感受性カリウムチャンネル

The aim of this study was to determine the role of ATP-sensitive potassium channels in regulation of coronary blood flow. Experiments were performed in anesthetized dogs. The results are as follows.1) Regulation of Basal Coronary Blood FlowIntracoronary infusion of glibenclamide (a specific blocker of the channel) decreased coronary blood flow without altering arterial pressure and heart rate. Pretreatment of pinacidil prevented the glibenclamide-induced decreases in coronary blood flow.This study was published in Am J Physiol 1992.2) Regulation of Metabolic Coronary VasodilationGlibenclamide attenuated coroary vasodilation induced by isoproterenol and denopamine, but did not affect coronary vasodilation induced by nitroglycerin.This study was published in Am J Physiol 1994.3) AutoregulationA relationship between coronary blood flow and perfusion pressure was studied. Intracoronary glibenclamide inhibited coronary autoregulatory coronary vasodilation. The response was reproducible during vehicle infusion.This study was published in Circulation Research 1993.

本研究的目的是确定ATP敏感性钾通道在调节冠状动脉血流中的作用。实验在麻醉的狗中进行。结果如下：1）基础冠脉血流量的调节冠脉内注射格列本脲（一种特异性的通道阻断剂）可减少冠脉血流量，而不改变动脉压和心率。吡那地尔的预处理防止了格列本脲诱导的冠状动脉血流量的减少。这项研究发表在美国生理学杂志1992年。2）代谢性冠状动脉血管舒张的调节格列本脲减弱了异丙肾上腺素和地诺帕胺诱导的冠状动脉血管舒张，但不影响硝酸甘油诱导的冠状血管舒张。这项研究发表在美国生理学杂志1994年3月。）研究了冠状动脉血流和灌注压之间的关系。冠状动脉内注射格列本脲可抑制冠状动脉自身调节性血管舒张。该研究发表在1993年的《循环研究》上。

项目成果

Akatsuka Y: "ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dogs" Cardiovasc Res. 28. 906-911 (1994)

Akatsuka Y：“ATP 敏感钾通道参与腺苷 A2 受体介导的狗冠状血管舒张”Cardiovasc Res。

Narishige T: "Glibenclamide inhibits coronary autoregulation in anesthetized dogs." Circulation Research. 73. 771-776 (1993)

Narishige T：“格列本脲抑制麻醉狗的冠状动脉自动调节。”

Akatsuka Y: "ATP sensitive potassium channels are involved in adenisine A2 receptor mediated coronary vasodilation" Cardiovasc Res. 28. 906-911 (1994)

Akatsuka Y：“ATP 敏感钾通道参与腺苷 A2 受体介导的冠状血管舒张”Cardiovasc Res。

Imamura Y: "Glibenclamide decreases basal coronary flow in anesthetized dogs." Am J Physiol. 263. H339-H404 (1992)

Imamura Y：“格列本脲会降低麻醉狗的基础冠状动脉流量。”

Narishige T: "Glibenclamide prevents coronary vasodilation induced by 1-adrenoceptor stimulation in dogs." Am J Physiol. 266. H84-H92 (1994)

Narishige T：“格列本脲可预防狗 1-肾上腺素受体刺激引起的冠状血管舒张。”