Basic and Clinical Research for Hepatitis C Virus Infection with Malignant Disease in Childhood

对10例白血病及其他恶性疾病完全恢复的丙型肝炎病毒(丙型肝炎病毒)感染者进行了干扰素治疗。转氨酶水平轻度升高的有8例，但仍有2例正常。干扰素治疗前肝活检病理结果均为慢性迁延性或侵袭性肝炎。在4例患者中，停用干扰素治疗一年后，血清中仍未检测到丙型肝炎病毒核糖核酸。这些病例的肝脏病理表现均有明显改善。3例经干扰素治疗后，丙型肝炎病毒RNA一过性消失，转氨酶水平再次升高。肝功能、病理改变与IFN疗效之间无相关性。结论：干扰素治疗儿童恶性肿瘤合并丙型肝炎是有效的。

We evaluated the efficacy of interferon (IFN) therapy for ten cases with hepatitis C virus (HCV) infection, who had completely recovered from leukemia and other malignant diseases. The transaminase level was mildly elevated in eight cases, though remained normal in two cases. The pathological findings of liver biopsy before the IFN therapy showed persistent or aggressive chronic hepatitis in all cases. In four cases, HCV-RNA was continuously undetectable in the sera over one year after the cessation of IFN therapy. The pathological findings of the liver were remarkably improved in these cases. In three cases, disappearance of HCV-RNA was transient and the transaminase level was elevated again after the IFN therapy. No correlation was observed among the liver function, pathological finding, and the response to IFN.We concluded that the IFN therapy for the HCV infected children with malignancies was effective.