Basic and Clinical Research for Hepatitis C Virus Infection with Malignant Disease in Childhood

儿童丙型肝炎病毒感染并发恶性肿瘤的基础与临床研究

• 批准号: 05670687
• 负责人: IKUTA Koichiro
• 金额: $ 1.15万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670687/
• 关键词: Malignant diseases; Hepatitis C; Liver Biopsy; IFN-therapy; RT-PCR; C型肝炎; HCV-RNA; HCV subtype

We evaluated the efficacy of interferon (IFN) therapy for ten cases with hepatitis C virus (HCV) infection, who had completely recovered from leukemia and other malignant diseases. The transaminase level was mildly elevated in eight cases, though remained normal in two cases. The pathological findings of liver biopsy before the IFN therapy showed persistent or aggressive chronic hepatitis in all cases. In four cases, HCV-RNA was continuously undetectable in the sera over one year after the cessation of IFN therapy. The pathological findings of the liver were remarkably improved in these cases. In three cases, disappearance of HCV-RNA was transient and the transaminase level was elevated again after the IFN therapy. No correlation was observed among the liver function, pathological finding, and the response to IFN.We concluded that the IFN therapy for the HCV infected children with malignancies was effective.

本文报告了10例丙型肝炎病毒（HCV）感染者经干扰素（IFN）治疗后，白血病及其它恶性肿瘤痊愈的疗效。转氨酶水平轻度升高8例，但仍在2例正常。治疗前肝活检病理结果均为持续性或侵袭性慢性肝炎。在4例中，HCV-RNA持续检测不到血清中超过一年后停止干扰素治疗。肝组织病理学检查均明显改善。在3例病例中，HCV-RNA的消失是短暂的，转氨酶水平在IFN治疗后再次升高。肝功能、病理改变与IFN疗效无相关性，提示IFN治疗HCV感染的恶性肿瘤患儿是有效的。

项目成果

Y.Ishida, J.Levin, G.Baker: "PE.Stenberg, Y.Yamada, H.Sasaki, T.Inoue : Biological and biochemical charecteristicsof murine megakaryoblasticcell line L8057." Experimental Hematol. 21. 289-298 (1993)

Y.Ishida、J.Levin、G.Baker：“PE.Stenberg、Y.Yamada、H.Sasaki、T.Inoue：鼠巨核细胞系 L8057 的生物学和生化特征。”

K.Ikuta, K.Fujioka, H.Sumita, H.Takahashi, H.Sekigushi, S.Kai, Y.Kajigaya, T.Funabiki.H.Sasaki, S.Matsuyama: "High-Dose Busulfan, VP-16 and ACNU Therapy with Stem Cell Transplantation for the Treatment of Children with Acute Leukemia." Jpn.J.Clin.Hematol.

K.Ikuta、K.Fujioka、H.Sumita、H.Takahashi、H.Sekigushi、S.Kai、Y.Kajigaya、T.Funabiki.H.Sasaki、S.Matsuyama：“高剂量白消安、VP-16 和

K.Ikuta, K.Fujioka, H.Tkahashi, H.Sumita, H.Sekiguchi, N.Hanzawa, S.Kai, Y.Kajigaya, T.Funabiki.T.Okuyama, H.Sasaki, S.Matsuyama: "Treatment and Prognosis after Late Relapse in Childhood Acute Lymphoblastic Leukemia." Jpn.J.Clin.Hematol.34. 712-717 (1993)

K.Ikuta、K.Fujioka、H.Tkahashi、H.Sumita、H.Sekiguchi、N.Hanzawa、S.Kai、Y.Kajigaya、T.Funabiki.T.Okuyama、H.Sasaki、S.Matsuyama：“治疗

T.Inoue, Y.Hirabayashi, H.Sasaki, M.Matsuda, Y.Furuta, S.Aizawa: "Model of MDS-like myelodysplasia that transforms into single lineage-hemopoietic malignancies upon transplantation -Implication for pediatric myelodysplastic syndrome-" Int.J.Pedat.Oncol.He

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M.Tsukaada, A.Komiyama, S.Nakazawa, M.Tsuchida, H.Nishihira, T.Shitara, M.Ohira, Y.Tsunematsu, K.Yamamoto, Y.Hoshi, K.Yamada, R.Hosoya, T.Sato, F.Bessho, I.Tsukimoto, M.Yamamoto, K.Ikuta, T.Saito, K.Nishimura, and the Tokyo Children Cancer Study Group: "T

M.Tsukaada、A.Komiyama、S.Nakazawa、M.Tsuchida、H.Nishihira、T.Shitara、M.Ohira、Y.Tsunematsu、K.Yamamoto、Y.Hoshi、K.Yamada、R.Hosoya、T.