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Disturbed brain areas in schizophrenia and their relationship to psychiatric symptoms.

精神分裂症的大脑区域紊乱及其与精神症状的关系。

基本信息

批准号：
05670819
负责人：
KISHIMOTO Hideji
金额：
$ 1.41万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670819/
关键词：
MRS NAA Cho (choline)schizophrenia psychiatric symptoms blunted affect delusion hallucinations choline ポジトロンCT 脳血流量

项目摘要

Using PET tracer, the authors measured cerebral blood flow (CBF), cerebral metabolic rate of oxygen (CMRO2) and glutamic acid pools in drug-naive chronic schizophrenic patients, and found decreased brain activity in the association areas of cortex. The CBF and CMRO2 were increased in the thalamus and the cingulate in drug-naive acute schizo-phrenic patients.Concerning psychiatric symptoms in chronic schizophrenia, the hypoactivity in the frontal area was found in patients with symptoms of blunted affect and social withdrawal, whereas that in the parietal or temporal repion correlated with symptoms of delusion. However, hyperactivity was found in the thalamus and cingulate cortex in drug-naive acute schizophrenic patients with auditory hallucinations and excitability.NAA (N-acetyl aspartic acid) and choline (Cho) were measured using proton MRS (magnetic resonance spectroscopy) in the frontal white matter region in drug-naive schizophrenic patients. NAA and Cho intensities were significantly decreased (p<0.001) in the frontal white matter region in drug-naive schizophrenic patients. NAA and Cho also showed positive correlations (p<0.025) in drug-naive schizophrenic patients whereas there was no correlation in normal controls. Reductions of the NAA and Cho concentrations in the frontal white matter in schizophrenic patients indicates a decrease in the neuronal network or the membrane alterations in schizophrenics.

本文应用PET示踪剂测定了未用药的慢性精神分裂症患者的脑血流量（CBF）、脑氧代谢率（CMRO_2）和谷氨酸池，发现脑皮层联合区活动减少。在慢性精神分裂症的精神症状方面，额叶活动减退主要见于情感迟钝和社会退缩症状，而顶叶或颞叶反应减退则与妄想症状有关。本文应用质子磁共振波谱（MRS）技术检测了未用药精神分裂症患者额叶白色区的N-乙酰天冬氨酸（NAA）和胆碱（Cho）。药物初治精神分裂症患者额叶白色区NAA和Cho强度显著降低（p<0.001）。初治精神分裂症患者NAA与Cho呈正相关（p<0.025），而正常对照组无相关性。精神分裂症患者额叶白色物质中NAA和Cho浓度的降低表明精神分裂症患者的神经元网络减少或膜改变。