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The study of the brain receptors in schizophrenia and affective disorders.

精神分裂症和情感障碍中大脑受体的研究。

基本信息

批准号：
01480282
负责人：
KISHIMOTO Hideji
金额：
$ 4.29万
依托单位：
Yokohama City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480282/
关键词：
PET schizophrenia affective disorders CBF CMRO2 glutamic acid pools receptors グルタミン酸プ-ル 5ーHT_2 DA そううつ病

项目摘要

Using the tracer of C1502, 1502 and 11C-glucose, the authors measured the cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO2) and glutamic acid pools by PET in acute and chronic schizophrenic patients, manicdepressive patients who have not received antipsychotic drugs and in control subjects. Diagnosis of disorders were done by DSM-III-R criteria.The CBF and CMRO2 were under 60ml or 6ml/100gr brain/min in normal controls. The CBF and CMRO2 were increased over 80ml or 8ml/100gr brain/min in the thalamus, the cingulate and the temporal cortex in acute schizophrenic patients, who have no drugs. On the other hand the CBF, CMRO2 and glutamic acid pools were decreased in the association areas of the cortex in chronic schizophrenic patients. These decreases or increases in the CBF, the CMRO2 and glutamic acid pools in schizophrenic patients have a tendency to return to normal values after antipsychotic drug therapy.The bipolar manic patients showed globally increased cortical glutamic acid pools, whereas unipolar depressed patients showed reduced cortical glutamic acid pools.The most impaired cortical areas in chronic schizophrenic patients were Brodmann's areas 10, 38, 40 which are named the association areas where human being are creative : language, concept, culture and society.

本文应用~（1502）C、~（1502）C和~（11）C-葡萄糖示踪剂，用正电子发射计算机断层扫描（PET）测定了急性、慢性精神分裂症患者、未服用抗精神病药物的躁狂抑郁症患者和正常对照组的脑血流量（CBF）、脑氧代谢率（CMRO_2）和谷氨酸池。按DSM-III-R诊断标准，正常对照组CBF、CMRO_2均低于60 ml或6 ml/100 gr脑/min。急性期精神分裂症患者未经药物治疗时，丘脑、扣带回和颞叶皮质CBF和CMRO_2均高于80 ml或8 ml/100 gr脑/min。另一方面，慢性精神分裂症患者皮层联合区的CBF、CMRO 2和谷氨酸池减少。精神分裂症患者CBF、CMRO 2和谷氨酸池的减少或增加在抗精神病药物治疗后有恢复正常值的趋势。双相躁狂患者表现出全面增加的皮层谷氨酸池，而单相抑郁患者表现出减少的皮层谷氨酸池。慢性精神分裂症患者受损最严重的皮层区域是Brodmann 10区、38区、40个被命名为人类创造性的联想领域：语言、观念、文化和社会。