総動脈幹残遺症の肺動脈の胎生期形態に関する基礎的研究

残留总动脉干的肺动脉胚胎形态基础研究

• 批准号: 05670976
• 负责人: 門間 和夫
• 金额: $ 1.28万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670976/
• 关键词: 総動脈幹残遺症,; 先天性心疾患; 胎生期循環,; 肺高血圧症,

私達は妊娠ラット100匹を用い,妊娠9日,10日にbis-diamine 200mgを胃内注入して21日(満期)に全身急速凍結法で胎仔を固定し,心臓と大血管の生体内形態を研究した。胎仔900匹の研究により総動脈幹残遺症100匹の心臓・大血管の研究が出来た。その成果は次の如くであり,一部は論文として発表出来た。1.ビスダイアミン投与によりラット胎仔に総動脈幹残遺症の1,2,3型(Collett-Edwards分類)に相当する病変が生じた。これらのラットの胎仔の心臓と大血管の断面写真により,心臓と大血管の形態が明瞭に観察された。2.これらラット胎仔には総動脈幹残遺症の重症化の1要因である総動脈幹弁の逆流が胎生期にも生じた。胎生期に総動脈幹弁逆流が高度の場合は,総動脈幹の拡張,心室の拡張,胎生期心不全が生じた。総動脈幹弁の逆流は,弁の肥厚と変形に関連して生じていた。3.これら総動脈幹残遺を有するラット胎仔では右,及び左肺動脈の太さは特に他の先天性心疾患合併例と差が無く,また先天性心疾患を合併しない胎仔とも差が無かった。従って総動脈幹残遺症の胎生期の肺循環は胎生期の特徴はあるが,先天性心疾患の無い場合と差が無い,と結論された。4.総動脈幹残遺症はDiGeorge症候群に合併して生じる事が知られている。またDiGeorge症候群は染色体22q11の欠失により生じる事が最近判明した。従ってビスダイアミン投与により生じる心臓血管奇形は22q11欠失の動物モデルになる。

During pregnancy, bis-diamine 200 mg was injected into the stomach on the 9th and 10th day of pregnancy. The fetus was fixed by whole-body rapid freezing method. The morphology of the heart and great blood vessels was studied in vivo. 900 Fetal Study of Cardiovascular Diseases 100 Fetal Study of Cardiovascular Diseases The results of the research are as follows: a paper is published. 1. The development of severe fetal aortic stump disease types 1, 2, and 3 (Collett-Edwards classification) is caused by vitiligo injection. The cross section of the fetal heart and great vessels was photographed, and the morphology of the great vessels was clearly observed. 2. One of the main causes of the severity of multi-arterial residual disease in this fetus is the countercurrent of the multi-arterial trunk that occurs during the prenatal period. In the prenatal period, the arterial trunk reflux is high, the arterial trunk is dilated, the ventricle is dilated, and the heart is incomplete in the prenatal period. The main artery of the artery is reverse flow, and the main artery is hypertrophic. 3. There is no difference between congenital heart disease and congenital heart disease in the right and left pulmonary arteries. The characteristics of pulmonary circulation in fetal period of congenital heart disease are different from those in fetal period. 4. The complications of coronary artery disease and DiGeorge syndrome are complicated and the symptoms are unknown. DiGeorge syndrome has been recently identified as a missing chromosome 22q11. The blood vessels of the heart and the blood vessels of the heart are abnormal.

项目成果

Momma K et al: "In-situ morphology of fetal aortic isthmus following ductal constriction in rats." Fetal Diagnosis and Therapy. 9. 53-61 (1994)

Momma K 等人：“大鼠导管收缩后胎儿主动脉峡部的原位形态。”

Momma K et al.: "Fetal cardiovascular morphology of truncus arteriosus with or without truncal valve insufficiency" Circulation. 83. 2094-2100 (1989)

Momma K 等人：“伴有或不伴有动脉干瓣膜关闭不全的胎儿动脉干的心血管形态”循环。

Momma K et al: "Fetal cardiovascular morphology of interrupted aortic arch type B in rats." Fetal Diagnosis and Therapy. 9. 44-52 (1994)

Momma K 等人：“大鼠 B 型主动脉弓中断的胎儿心血管形态。”

Wu FF,Momma K et al: "Cardiovascular and pulmonary effects of betamethasone during midtrimester on fetal rats" Fetal Diagnosis and Therapy. 8. 89-94 (1993)

Wu FF，Momma K 等：“妊娠中期倍他米松对胎儿大鼠的心血管和肺部影响”胎儿诊断和治疗。

Momma K et al: "In-situ pulmonary vascular morphology and lung volume in fetal and neonatal rat" Early Human Development. 34. 191-198 (1993)

Momma K 等人：“胎儿和新生大鼠的原位肺血管形态和肺容量”早期人类发育。