Study of the neutrophil functions in pregnancy

(1)钙离子载体诱导的中性粒细胞释放白三烯B4在正常妊娠的第2、3个月受到抑制，而在毒血症妊娠中没有。(2)毒血症患者中性粒细胞白三烯B4释放量与非孕妇相同，且与各胎龄出生体重及其z分显著相关。(3)中性粒细胞磷脂中花生四烯酸含量和摩尔%随妊娠周的增加而降低。(4)不饱和脂肪酸/饱和脂肪酸比值随妊娠周的增加而降低。(5)这些结果提示，在正常妊娠中，中性粒细胞的激活在白三烯B4释放和膜流动性方面受到抑制，这些机制的紊乱可能导致妊娠毒血症。(6)中性粒细胞弹性酶含量和pma刺激的中性粒细胞弹性酶释放量在孕妇、非孕妇和男性之间没有差异。

(1) Calcium ionophore-induced leukotriene B4 release from neutrophils is suppressed in 2nd and 3rd trimester of normal pregnancy but not in toxemic pregnancy.(2) Released amounts of leukotriene B4 from neutrophils of toxemic patients are at identical level with nonpregnant women and significantlly correlated with birth weights and its z scores at each gestational age.(3) Arachidonic acid content and mole% in phospholipids of neutrophils decreased with gestational weeks.(4) Ratio of unsaturated fatty acid/saturated fatty acid decreased with gestational weeks.(5) These findings suggest that the neutrophil activation is suppressed in normal pregnancy in terms of leukotriene B4 release and of the fluidity of the membrane and that disorders of these mechanism seem to induce toxemia of pregnancy.(6) Elastase contents of neutrophils and PMA-stimulated elastase release from neutrophil are not different among pregnant, non-poregnant woman and men.