Bacteriological study for periodontal disease proceeding

这项纵向研究的目的是评估某些临床和微生物学变量在两年时间内预测牙周病进展的应用。将30名牙科学生(基线年龄22-31岁)的22名牙周炎患者分为两组，15名牙周菌斑中有腐蚀性艾氏杆菌的受试者(第1组：C1)和7名无腐蚀性艾克氏杆菌的受试者(第2组：C2)。在每6个月的5次访问中，对受试者进行临床和微生物学检查。结果显示，在整个纵向研究中，C_1组和C_2组的临床参数无显著差异。多元回归分析显示，从基准年到1年，牙周指数(GI)和牙袋深度(PD)的变化以龈下细菌因素解释的方差最大(38%，39%)。对于1年以上GI和PD的变化，活动杆和中间普氏杆菌有显著的回归系数。逐步Logistic回归分析结果显示，运动杆与PD的增加呈显著正相关，其优势比(106.4)非常高。这些结果表明，活动杆的存在和比例与牙周炎的增加显著相关。这项研究表明，可动杆可以可靠地用于预测牙周炎的进展。

The aim of this longitudinal study was to evaluate the use of certain clinical and microbiological variables to predict periodontal disease proceeding during a 2-year period. 22 subjects with gingivitis of 30 dental students (aged 22-31 at baseline) participated in this study were divided into 2 groups, 15 subjects with Eikenella corrodens in subgingival plaque (Cluster 1 : C1) and 7 subjects without E.corrodens (Cluster 2 : C2). The subjects were examined clinically and microbiologically at each of the 5 visits every 6 months. The results showed that there was no significant differences of clinical parameters in C1 and C2 groups throughout the longitudinal study. The analysis using the multiple regression method showed that the variance explained by the subgingival bacteria factors was highest (38%, 39%) for the change in gingival index (GI) scores and pocket depth (PD) from baseline yearto 1 year. For the change of GI and PD over 1 year, motile rods and Prevotella intermedia had a significant regression coefficient. The result of stepwise logistic regression analysis indicated that motile rods was significantly positive associated with the increase in PD,and had very higher odds (106.4). These results indicate that both presence and proportion of motile rods are significantly associated with the increase in gingival inflammation. This study suggests that motile rods can be used reliably to predict gingivitis progression.