Bacteriological study for periodontal disease proceeding

牙周病的细菌学研究

• 批准号: 05671710
• 负责人: TSURUDA Keiko
• 金额: $ 1.41万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671710/
• 关键词: Gingivitis; Risk marker; Subgingival bacteria; Eikenella corrodens; 病態変化; 臨床状態; 追跡調査; 臨床所見

The aim of this longitudinal study was to evaluate the use of certain clinical and microbiological variables to predict periodontal disease proceeding during a 2-year period. 22 subjects with gingivitis of 30 dental students (aged 22-31 at baseline) participated in this study were divided into 2 groups, 15 subjects with Eikenella corrodens in subgingival plaque (Cluster 1 : C1) and 7 subjects without E.corrodens (Cluster 2 : C2). The subjects were examined clinically and microbiologically at each of the 5 visits every 6 months. The results showed that there was no significant differences of clinical parameters in C1 and C2 groups throughout the longitudinal study. The analysis using the multiple regression method showed that the variance explained by the subgingival bacteria factors was highest (38%, 39%) for the change in gingival index (GI) scores and pocket depth (PD) from baseline yearto 1 year. For the change of GI and PD over 1 year, motile rods and Prevotella intermedia had a significant regression coefficient. The result of stepwise logistic regression analysis indicated that motile rods was significantly positive associated with the increase in PD,and had very higher odds (106.4). These results indicate that both presence and proportion of motile rods are significantly associated with the increase in gingival inflammation. This study suggests that motile rods can be used reliably to predict gingivitis progression.

这项纵向研究的目的是评估使用某些临床和微生物学变量来预测牙周病的进展，在2年的时间。将30名牙科学生（基线年龄22-31岁）的22名牙龈炎受试者分为2组，15名受试者龈下菌斑中有腐蚀性艾肯菌（第1组：C1），7名受试者无腐蚀性艾肯菌（第2组：C2）。在每6个月的5次访视中，对受试者进行临床和微生物学检查。结果表明，在整个纵向研究中，C1和C2组的临床参数无显著差异。多元回归分析显示龈下细菌因素对牙龈指数（GI）和牙周袋深度（PD）从基线年到1年的变化解释的方差最大（38%，39%）。对于GI和PD在1年内的变化，活动杆和中间普氏菌具有显著的回归系数。逐步Logistic回归分析结果显示，视杆细胞活动与PD的增加呈显著正相关，且有非常高的优势比（106.4）。这些结果表明，活动杆的存在和比例与牙龈炎症的增加显着相关。这项研究表明，活动杆可以可靠地用于预测牙龈炎的进展。