Preventive effect of involutional osteoprosis in exercised at different ages

为了阐明人体对渐进性骨质疏松症的预防作用，采用显微密度测定、力学性能测定、血清钙代谢分析等方法，研究了不同年龄运动对骨质疏松症的影响。将小鼠分为5组：1)生长期运动组（10-30w） (A)；2)成熟期训练组（31 ~ 50w） (B)；3)老年期运动组（51 ~ 70w） (C)；4)全周期运动组（10 ~ 70w） (D)；5)对照组（非运动组）。本研究结果总结如下：1)A、D、E组体重显著高于B组。2) E组骨密度显著低于其他4组。3) CTI在C、E组有低于其他组的趋势。4) E组断裂力和极限应力显著低于A、B、D组。5) D组变形量显著高于A组。6)弹性倾向于E组，E组与A、D组差异显著。7) C-PTH、CT、Ca水平E组与运动组比较差异无统计学意义。但P在E组有低于其他组的趋势。综上所述，这些结果支持了各个年龄段的运动都可能对人类老年性骨质疏松症有预防作用的观点，其效果表现为老年期运动组强于其他运动组。但是，这些结果似乎表明，运动中骨骼的含量在老年运动组和其他运动组之间是不同的。

In order to clarify the preventive effect of involutional osteoprosis in human, different responses to exercise at ages were examined by microdensitmetry, mechnical property test, analyzes of Ca metabolism in serum. The mice were divided into the following five groups : 1) growth period exercise group (10-30w) (A) ; 2) maturity period exercise group (31-50w) (B) ; 3) aged period exercise group (51-70W) (C) ; 4) all period exercise group (10-70W) (D) ; 5) control (non-exercise group) (E).The results of this study are summarized as follows :1) Body weight was fignificantly higher in A,D and E group than in B group.2) Bone density was significantly lower in E group than in other four groups.3) CTI showed tendency to be lower in C,E group than in other groups.4) Breaking force and U1timate stress were significant lower in E group than in A,B and D group.5) Deformation was significant higher in D group than in A group.6) Elasticity showed tendency to be E group than in other groups, significant difference between the E group and A or D group.7) There was no significant difference in C-PTH,CT,Ca between the E group and the exercise groups. But, P showed tendency to be lower in E group than in other groups.In summary, these results support the view that exercise at every age may be a prevention for involution osteoprosis in human being, its effect showed tendency to be aged period exercise group than other exercise group. But, these results seem to suggest that of bone in exercise make a difference between aged period exercise group and other exercise group.