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Orientation of erythrocytes and platelets in a strong static magnetic field.

Orientation of erythrocytes and platelets in a strong static magnetic field.
强静磁场中红细胞和血小板的定向。
批准号:
05680463
负责人:
HIGASHI Terumasa
金额:
$1.22万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1993
资助国家:
日本
项目状态:
已结题
起止时间:
1993 至 1994

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中文摘要
翻译
在均匀的静磁场中,完整的红细胞使其圆盘表面平行于磁场方向。这种取向是由红细胞膜成分、脂质双层和跨膜蛋白中的抗磁各向异性产生的,而不是由于血红蛋白分子的磁性。完整的血小板也采取了相同的方向作为完整的红细胞,但在这种情况下,不仅膜成分的磁性,而且细胞骨架蛋白,微管的磁各向异性的方向负责。相比之下,用戊二醛固定的红细胞显示出其圆盘表面垂直于磁场方向的取向。高铁血红蛋白分子的顺磁性被认为对这种取向有重要贡献。
英文摘要
In a homogeneous static magnetic field, intact erythrocytes oriented their disk surface parallel to the direction of magnetic field. This orientation was produced by diamagnetic anisotropies in the erythrocyte membrane components, the lipid bilayr and the transmembrane proteins, and was not due to the magnetism of hemoglobin molecules. Intact platelets also took the same orientation as intact erythrocytes, but in this case, not only the magnetic properties of membrane constituents but also the magnetic anisotropy of cytoskeletal protein, microtubules were responsible for the orientation. By contrast, erythrocytes fixed by glutaraldehyde showed an orientation in which their disk surface was vertical to the direction of magnetic field. The paramagnetism of methemoglobin molecules is thought to contribute significantly to this orientation.
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