Orientation of erythrocytes and platelets in a strong static magnetic field.

强静磁场中红细胞和血小板的定向。

• 批准号: 05680463
• 负责人: HIGASHI Terumasa
• 金额: $ 1.22万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05680463/
• 关键词: Static magnetic field; Magnetic anisotropy; Erythrocyte; Blood platelet; Glutaraldehyde; Biological membrane; Hemoglobin; Magnetic orientation; マイクロツブルス

In a homogeneous static magnetic field, intact erythrocytes oriented their disk surface parallel to the direction of magnetic field. This orientation was produced by diamagnetic anisotropies in the erythrocyte membrane components, the lipid bilayr and the transmembrane proteins, and was not due to the magnetism of hemoglobin molecules. Intact platelets also took the same orientation as intact erythrocytes, but in this case, not only the magnetic properties of membrane constituents but also the magnetic anisotropy of cytoskeletal protein, microtubules were responsible for the orientation. By contrast, erythrocytes fixed by glutaraldehyde showed an orientation in which their disk surface was vertical to the direction of magnetic field. The paramagnetism of methemoglobin molecules is thought to contribute significantly to this orientation.

在均匀的静磁场中，完整的红细胞表面取向平行于磁场方向。这种取向是由红细胞膜成分、脂双层和跨膜蛋白中的抗磁各向异性引起的，而不是由于血红蛋白分子的磁性。完整的血小板也与完整的红细胞具有相同的取向，但这种取向不仅与膜组分的磁性有关，还与细胞骨架蛋白、微管的磁各向异性有关。相反，用戊二醛固定的红细胞显示出其磁盘表面垂直于磁场方向的取向。高铁血红蛋白分子的顺磁性被认为对这种取向有很大贡献。

项目成果

TERUMASA HIGASHI: "Orientotion of glutaraldehyde-fieed erythrocytes in strong Static magnetic fields." Bioelectro-maynetics. (in press). (1995)

TERUMASA HIGASHI：“强静磁场中戊二醛填充的红细胞的定向。”

Higashi, Terumasa: "Orientation of erythrocytes in a strong static magnetic field." Blood. 82. 1328-1334 (1993)

Higashi, Terumasa：“红细胞在强静磁场中的定向。”

TERUMASA HIGASHI: "Effects of a strong static magnetic field on blood platelets." Platelets. 4. 341-342 (1993)

TERUMASA HIGASHI：“强静磁场对血小板的影响。”

TERUMASA HIGASHI: "Effects of static magnetic fields on erythrocyte rheology." Bioelectrochemistry and Bioenergetics. (in press). (1995)

TERUMASA HIGASHI：“静磁场对红细胞流变学的影响。”

東 照正: "静置した血漿中の血小板に及ぼす強い定常磁場の影響." 医学のあゆみ. 166. 143-144 (1993)

Terumasa Azuma：“强稳定磁场对静态血浆中血小板的影响。”医学史 166. 143-144 (1993)