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Effects of static magnetic field on cell formation, adhesion and migration.

静磁场对细胞形成、粘附和迁移的影响。

基本信息

批准号：
14580818
负责人：
HIGASHI Terumasa
金额：
$ 1.98万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14580818/
关键词：
human brain tumor cell static magnetic field magnetic orientation cell migration cell adhesion cell investigation cell proliferation diamagnetism ヒト脳腫瘍膠芽細胞

项目摘要

In late years, experiment and epidemiologic studies about magnetic field influence for the human body is performed flourishingly and get much knowledge. However, the dispute that magnetic field promotes the clinical onset of malignant tumor does not yet get an end.We examined it about "Effects of static magnetic field on cell information, adhesion and migration". It is based on the hypothesis that the clinical onset rate might change if there is an effect of magnetic fields on a metastasis stage of malignant tumor, even if there is no influence at the gene level like ionizing radiation (X-rays and gamma ray). As the elements like cell formation, adhesion and migration go participated for metastasis of a malignant tumor, we observed each function of tumor cells (A172, A175, T98G, YKG-1) under steady magnetic fields.Especially, the effect on brain tumor migration was clearly recognized using Wound Assay method. Uneven distribution of cytoskeleton protein in the cell was also observed by an immunity staining. The course and degree of restraint/promotion were different by the kind of the brain tumor cells. It will be a future problem to be settled what variety of these magnetic field influence is caused by.In general, when we investigate the previous academic papers, we cannot deny electromagnetic wave influence in an epidemiologic study. However, we cannot clarify the clear action mechanism in previous experiment studies. If we want to bury the estrangement and show a clear safety level of electromagnetic wave on human body in future, the viewpoint that the clinical onset rate of a malignant tumor may change if there is an effect of magnetic fields on a metastasis stage of malignant tumor, even if there is no influence at the gene level like ionizing radiation (X-rays and gamma ray) as above.

近年来，有关磁场对人体影响的实验和流行病学研究不断开展，并取得了一定的成果。然而，磁场促进恶性肿瘤临床发病的争论仍未结束，我们对“静磁场对细胞信息、粘附和迁移的影响”进行了研究。这是基于这样的假设，即如果磁场对恶性肿瘤的转移阶段有影响，即使在基因水平上没有电离辐射（X射线和伽马射线）的影响，临床发病率也可能发生变化。由于细胞形成、粘附和迁移等因素参与了恶性肿瘤的转移，我们观察了稳恒磁场下肿瘤细胞（A172、A175、T98 G、YKG-1）的各项功能，特别是采用伤口分析法清晰地认识到了对脑肿瘤迁移的影响。免疫染色观察到细胞骨架蛋白分布不均匀。抑制/促进的过程和程度因脑肿瘤细胞的种类而异。这些磁场影响的种类是什么将是一个有待解决的问题。一般来说，当我们调查以前的学术论文，我们不能否认电磁波在流行病学研究中的影响。然而，在以往的实验研究中，我们无法阐明明确的作用机制。如果我们想在将来消除隔阂并显示电磁波对人体的明确安全水平，那么如果在恶性肿瘤的转移阶段存在磁场的影响，则恶性肿瘤的临床发病率可能会改变，即使在基因水平上没有像上述电离辐射（X射线和伽马射线）那样的影响。