Effects of static magnetic field on cell formation, adhesion and migration.

近年来，关于磁场对人体影响的实验和流行病学研究蓬勃开展，并获得了大量的知识。然而，关于磁场促进恶性肿瘤临床发病的争论还没有结束。我们就静磁场对细胞信息、黏附和迁移的影响进行了审查。它是基于这样的假设，即即使在基因水平上没有电离辐射(X射线和伽马射线)的影响，如果磁场对恶性肿瘤的转移阶段有影响，临床发病率也会发生变化。肿瘤细胞A172、A175、T98G、YKG-1等细胞在恒定磁场作用下，由于细胞的形成、黏附和迁移等因素参与了肿瘤的转移，我们观察了这些细胞在恒定磁场下的各项功能，特别是通过创伤分析方法明确了肿瘤细胞对脑肿瘤迁移的影响。免疫染色显示细胞骨架蛋白分布不均。抑制/促进的过程和程度因脑瘤细胞的种类而异。这些磁场的影响是由什么引起的还是一个有待解决的问题。总的来说，当我们考察以前的学术论文时，我们不能否认电磁波在流行病学研究中的影响。然而，在以往的实验研究中，我们不能阐明其明确的作用机制。如果我们想要掩盖这种隔阂，并在未来展示一个明确的电磁波对人体的安全水平，那么，如果磁场对恶性肿瘤转移阶段的影响，即使在基因水平上没有上述电离辐射(X射线和伽马射线)的影响，恶性肿瘤的临床发病率也可能发生变化的观点。

In late years, experiment and epidemiologic studies about magnetic field influence for the human body is performed flourishingly and get much knowledge. However, the dispute that magnetic field promotes the clinical onset of malignant tumor does not yet get an end.We examined it about "Effects of static magnetic field on cell information, adhesion and migration". It is based on the hypothesis that the clinical onset rate might change if there is an effect of magnetic fields on a metastasis stage of malignant tumor, even if there is no influence at the gene level like ionizing radiation (X-rays and gamma ray). As the elements like cell formation, adhesion and migration go participated for metastasis of a malignant tumor, we observed each function of tumor cells (A172, A175, T98G, YKG-1) under steady magnetic fields.Especially, the effect on brain tumor migration was clearly recognized using Wound Assay method. Uneven distribution of cytoskeleton protein in the cell was also observed by an immunity staining. The course and degree of restraint/promotion were different by the kind of the brain tumor cells. It will be a future problem to be settled what variety of these magnetic field influence is caused by.In general, when we investigate the previous academic papers, we cannot deny electromagnetic wave influence in an epidemiologic study. However, we cannot clarify the clear action mechanism in previous experiment studies. If we want to bury the estrangement and show a clear safety level of electromagnetic wave on human body in future, the viewpoint that the clinical onset rate of a malignant tumor may change if there is an effect of magnetic fields on a metastasis stage of malignant tumor, even if there is no influence at the gene level like ionizing radiation (X-rays and gamma ray) as above.