Effects of static magnetic field on cell formation, adhesion and migration.

近年来，关于磁场对人体影响的实验和流行病学研究蓬勃开展，取得了不少成果。然而，关于磁场促进恶性肿瘤临床发病的争论尚未结束。我们研究了“静电磁场对细胞信息、粘附和迁移的影响”。它是基于这样的假设：即使在基因水平上没有像电离辐射（x射线和伽马射线）那样的影响，但如果磁场对恶性肿瘤的转移阶段有影响，临床发病率也会发生变化。由于细胞形成、粘附和迁移等因素参与了恶性肿瘤的转移，我们观察了稳定磁场下肿瘤细胞（A172、A175、T98G、YKG-1）的各项功能。特别是对脑肿瘤迁移的影响在创面实验中得到了明确的认识。免疫染色还观察到细胞骨架蛋白在细胞内分布不均匀。脑肿瘤细胞种类不同，抑制/促进的过程和程度也不同。这些磁场的影响是由哪种变化引起的，这将是一个有待解决的问题。总的来说，当我们研究以往的学术论文时，我们不能否认电磁波在流行病学研究中的影响。然而，在以往的实验研究中，我们无法阐明其明确的作用机制。如果我们想要在未来埋葬这种隔阂，明确电磁波对人体的安全程度，那么即使没有像上述电离辐射（x射线和伽马射线）那样在基因水平上的影响，只要对恶性肿瘤的转移阶段有磁场的影响，就可能改变恶性肿瘤的临床发病率的观点。

In late years, experiment and epidemiologic studies about magnetic field influence for the human body is performed flourishingly and get much knowledge. However, the dispute that magnetic field promotes the clinical onset of malignant tumor does not yet get an end.We examined it about "Effects of static magnetic field on cell information, adhesion and migration". It is based on the hypothesis that the clinical onset rate might change if there is an effect of magnetic fields on a metastasis stage of malignant tumor, even if there is no influence at the gene level like ionizing radiation (X-rays and gamma ray). As the elements like cell formation, adhesion and migration go participated for metastasis of a malignant tumor, we observed each function of tumor cells (A172, A175, T98G, YKG-1) under steady magnetic fields.Especially, the effect on brain tumor migration was clearly recognized using Wound Assay method. Uneven distribution of cytoskeleton protein in the cell was also observed by an immunity staining. The course and degree of restraint/promotion were different by the kind of the brain tumor cells. It will be a future problem to be settled what variety of these magnetic field influence is caused by.In general, when we investigate the previous academic papers, we cannot deny electromagnetic wave influence in an epidemiologic study. However, we cannot clarify the clear action mechanism in previous experiment studies. If we want to bury the estrangement and show a clear safety level of electromagnetic wave on human body in future, the viewpoint that the clinical onset rate of a malignant tumor may change if there is an effect of magnetic fields on a metastasis stage of malignant tumor, even if there is no influence at the gene level like ionizing radiation (X-rays and gamma ray) as above.