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Surgical Treatment of Chronic Pulmonary Thromboembolism (c-PTE) and the Trial to make an animal model of c-PTE with beagle

慢性肺血栓栓塞症（c-PTE）的手术治疗及比格犬制作c-PTE动物模型的试验

基本信息

批准号：
06454396
负责人：
NAKAJIMA Nobuyuki
金额：
$ 0.83万
依托单位：
CHIBA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

(1)Clinical Investigation :1.Result of surgical treatment for c-PTE patients. 25 patients of c-PTE were surgically treated in our hospital. 4 patients were dead during postoperative 30 days. The mortarity is 16.0%. But the other patients were obviously improved. The arterial blood gas in room air, cardiac index, mean-pulmonary arterial pressure and pulmonary vascular resistance are improved after operaton. The NYHA classifications of postoperative days are better than that of preoperative in 18 patients. They are in the NYHA 1 or 2.2.Selection of Surgical approach to pulmonary artery. We have two ways of approach to arrive at pulmonary artery, Through Median Approach and Through Lateral Thoracotomy Approach. We investigate the difference of postoperative results through median approach from through lateral thoracotomy approach.3.Pathological study of the specimen from patients'pulmonary artery during operation. We find that the specimens is classified into two kinds of character, firm … More and fragile. This character is very important for selective of approach during operation.4.We used the intravascular optical fiber scope. It is very useful to confirm back flow from distal pulmonary artery after thromboembolecty in c-PTE patients.(2)Trial to make an animal model of c-PTE with beagle :We give the Tranexamic acid to dogs, make thrombus in inferior vena cava of the dogs, and blow off it to pulmonary artery. So that we try to make a model of c-PTE.But we can't make that model. It is very difficult. We choose new method to make it. Now Dr.Masuda is staying at San Diego in U.S.A.and he is learning it from the pulmonary medical staff of the University of California, San Diego.(Summary) The surgical treatment of c-PTE is very useful. The quolity of life (QOL) of postoperative patients is better than that of preoperative. But we are not satisfied with that. The experiment of c-PTE is very important to understand the disease better, so that we want to make an animal model of c-PTE. Less

（1）临床研究：1. c-PTE患者的手术治疗结果。我院手术治疗c-PTE 25例。术后30天死亡4例。死亡率为16.0%。其余患者均明显好转。术后空气中动脉血气、心脏指数、平均肺动脉压、肺血管阻力均较术前明显改善。18例患者术后NYHA心功能分级优于术前。2.肺动脉手术入路的选择。我们有两种方法到达肺动脉，通过正中入路和通过侧开胸入路。比较正中切口与侧开胸切口手术效果的差异。3.术中肺动脉标本的病理学研究。我们发现，样本分为两种性质，坚定， ...更多信息而且很脆弱这一特点对手术入路的选择具有重要意义。4.采用血管内光纤内窥镜。明确c-PTE患者血栓栓塞后远端肺动脉返流是非常有用的。（2）Beagle犬c-PTE动物模型的制作：将氨甲环酸注射于犬下腔静脉，使其形成血栓，并将血栓吹至肺动脉。所以我们试图建立一个c-PTE的模型。但是我们做不到。这是非常困难的。增田博士现居美国圣地亚哥，师从圣地亚哥加州大学的肺科医务人员。（综述）手术治疗c-PTE是非常有效的。术后患者生活质量较术前明显改善。但我们对此并不满意。c-PTE的实验研究对进一步认识该病具有重要意义，因此我们希望建立c-PTE的动物模型。少