Metalloproteins and metalloenzymes

金属蛋白和金属酶

• 批准号: DP0557353
• 负责人: Em/Prof Jules Guss
• 金额: $ 15.62万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-04-14 至 2008-04-13
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0557353
• 关键词: Metalloproteins; metalloenzymes

Most of the chemical reactions and physical movements in living systems are carried out by proteins. The information for producing proteins from amino acids is stored in the genes, but many biological processes depend on additional atoms or molecules ('cofactors') that are added to a protein after it is assembled. For example, more than 30% of all proteins contain metal atoms which are essential for their function. We are studying the structures of such metalloproteins and metalloenzymes so that we can better understand their activities with long term aims of creating new molecules for biotechnology and/or drugs.

生命系统中的大多数化学反应和物理运动都是由蛋白质进行的。 从氨基酸产生蛋白质的信息存储在基因中，但许多生物过程依赖于在蛋白质组装后添加到蛋白质中的额外原子或分子（“辅因子”）。例如，超过30%的蛋白质含有对其功能至关重要的金属原子。 我们正在研究这些金属蛋白质和金属酶的结构，以便我们能够更好地了解它们的活性，从而为生物技术和/或药物创造新分子的长期目标。