The structure and function of dihydroorotase - an enzyme essential for pyrimidine biosynthesis

二氢乳清酶的结构和功能——嘧啶生物合成所必需的酶

• 批准号: DP0665282
• 负责人: Em/Prof Jules Guss
• 金额: $ 17.05万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-02-23 至 2008-11-21
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0665282
• 关键词: structure; function; dihydroorotase; enzyme; essential

Malaria has recently re-emerged as one of the major life threatening diseases worldwide. With increasing travel and climate change, malaria is increasingly endangering Australians at home and abroad. Our work aims to provide the basis for the rational design of a new class of anti-malarial drugs by the systematic and thorough analysis of an essential enzyme in the malarial parasite.

疟疾最近再次成为威胁世界各地生命的主要疾病之一。随着旅行和气候变化的增加，疟疾正日益危及国内外的澳大利亚人。我们的工作旨在通过对疟疾寄生虫中一种关键酶的系统和深入的分析，为合理设计一类新的抗疟疾药物提供依据。