Decoding modality-specific circuit function and neuromodulation in the Drosophila nociceptive network
解码果蝇伤害性网络中的模态特异性电路功能和神经调节
基本信息
- 批准号:436847066
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Research Grants
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
How specific behaviors are generated by sensory input-specific activation of neuronal networks is of fundamental importance for understanding nervous system function. This is also true for nociception, the ability to perceive and avoid harmful stimuli. Environmental inputs including heat and strong mechanical stimuli, which can be potentially harmful to an organism, are generally perceived as nociceptive and elicit a strong avoidance or escape response. The mammalian and Drosophila nociceptive systems are able to perceive and distinguish different noxious modalities including mechanical stimuli and high temperature. How these noxious cues are encoded by the underlying network and give rise to escape behavior is not fully understood. Using the Drosophila larval nociceptive network, we aim to elucidate the divergent encoding of noxious mechanical and thermal stimuli in this system. In Drosophila larvae, noxious heat or mechanical stimulation gives rise to a similar, highly stereotyped escape response. However, our previous work has shown that the underlying sensory networks differ and differentially require the action of a neuropeptide, the Neuropeptide Y homolog short Neuropeptide F (sNPF), for proper function. Using anatomical, functional and behavioral analyses, we aim to dissect the neuronal network subsets involved in mechano- or thermonociception. We will further investigate the relevant sources of the sNPF peptide, which are required to facilitate behavioral responses to heat or mechanical stimulation. Lastly, we will identify the neuronal subsets responding to sNPF and analyze the downstream signaling responses mediated by its receptor.Altogether, these approaches aim to elucidate how specific noxious stimuli elicit discrete neuronal network responses through recruitment of neuropeptide signaling.
神经网络的感觉输入特异性激活如何产生特定的行为是理解神经系统功能的基础。对伤害感觉也是如此,它是感知和避免有害刺激的能力。环境输入包括热量和强烈的机械刺激,它们可能对生物体有潜在的危害,通常被认为是伤害性的,并引起强烈的回避或逃避反应。哺乳动物和果蝇的伤害感知系统能够感知和区分不同的有害模式,包括机械刺激和高温。这些有害的线索是如何被潜在的神经网络编码并导致逃避行为的,目前还不完全清楚。利用果蝇幼虫的伤害感觉网络,我们旨在阐明该系统中有害的机械刺激和热刺激的不同编码。在果蝇幼虫中,有害的热量或机械刺激会引起类似的,高度刻板的逃避反应。然而,我们之前的工作已经表明,潜在的感觉网络是不同的,并且不同地需要神经肽的作用,神经肽Y同源的短神经肽F (sNPF),以维持正常的功能。利用解剖学,功能和行为分析,我们的目标是解剖参与机械或热感觉的神经网络子集。我们将进一步研究sNPF肽的相关来源,这是促进对热或机械刺激的行为反应所必需的。最后,我们将确定响应sNPF的神经元亚群,并分析其受体介导的下游信号反应。总之,这些方法旨在阐明特定的有害刺激如何通过招募神经肽信号引起离散的神经网络反应。
项目成果
期刊论文数量(0)
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Professor Dr. Peter Soba其他文献
Professor Dr. Peter Soba的其他文献
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{{ truncateString('Professor Dr. Peter Soba', 18)}}的其他基金
Dissecting Ret receptor signaling in space-filling dendrite patterning in Drosophila
解析果蝇空间填充树突图案中的 Ret 受体信号传导
- 批准号:
397556468 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Research Grants
Optogenetic silencing tools for precise, all-optical analysis of synaptic circuits
用于突触回路精确、全光学分析的光遗传学沉默工具
- 批准号:
315380903 - 财政年份:2016
- 资助金额:
-- - 项目类别:
Priority Programmes
Mechanisms of sensory circuit function, integration and neuromodulation in Drosophila melanogaster
果蝇感觉回路功能、整合和神经调节机制
- 批准号:
436846896 - 财政年份:
- 资助金额:
-- - 项目类别:
Heisenberg Grants
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