THE RESEARCH OF THE DIFFERENTIAL HYPOTHERMIA THERAPY FOR BRAIN TUMORS

为了探讨差异低温治疗人脑恶性肿瘤的临床应用，我们研究了体外微波辐射对肿瘤的影响范围和深度，并利用组织间微波辐射天线进行了活体实验，以达到在更精确的温度下对更精确的区域进行加热。在全身低温（30 ℃）条件下，微波天线对距天线半径2cm以内、距脑表面3cm以内的区域加热到37 ℃以上，显示了治疗效果，但该系统存在的问题之一是由于过热，在水循环微波消融针表面（超过50 ℃）的温度下，在水循环微波消融针附近的组织中观察到凝固、坏死和出血。为了防止过热，开发了一种用于组织间微波治疗的天线冷却系统，该系统由外径为5.0 mm的硅胶管构成。冷却由控制器提供 ...更多信息 恒定的水灌注允许在1cm半径内的42至44 ° C的组织温度范围内更均匀和准确地加热。并将一个边长为1.6cm的四根天线组成的正方形阵列插入脑内，采用耦合冷却系统。在这个四触角实验中，热场急剧变平，尺寸减小很少，然而，在治疗温度范围（42-45 ℃）内维持的区域被冷却系统显著扩大。在差异低温下，测量正常猴脑加热前后的局部脑血流量（1-CBF）。加热前白色物质的1-CBF为18.7 ± <plus-minus>9.8ml/100 g脑/min，加热后（30 ℃）比加热前增加约2 h。今后我们将致力于开发更有效的天线和天线引导系统，从病理学角度研究正常脑组织加热后的变化，并探讨脑组织加热的限制点。少

For the purpose of the clinical application of the differential hypothermia for human malignant brain tumors, we have studied the area and the depth that were affected by the external microwave irradiation.In order to heat more exact area at more exact temperature, next in vivo experiments were performed by using the interstitial microwave irradiation antenna. Under the generalized hypothermia (30ﾟC), a microwave antenna heated the area within 2 cm radius from the antenna and 3cm in depth from the brain surface at the degree of over 37ﾟC.This result indicated the therapeutic effect.But it is one of the problems with this system that because of the overheating (more than 50ﾟC) of the antenna surface, coagulation, necrosis and bleeding were observed in the tissues adjacent to the antenna. In order to prevent the overheating, a antenna cooling system for interstitial microwave therapy was developed, which was constructed of a silicone tube 5.0 mm in outer diameter. Cooling provided by con … More stant water perfusion allowed more uniform and accurate heating in the tissue temperatures the range of 42 to 44ﾟC within 1 cm radius. And the safety of this system was ensured by the histological examination.Moreover a square array (1.6cm on a side) of four antennae was inserted into the brain with the coupled cooling system. In this four-antennae experiments, thermal field was dramatically flattened with minimal reduction in size ; however, the area maintained at a therapeutic temperature range (42-45ﾟC) was significantly enlarged by the cooling system.Under differential hypothermia, the lical cerebral blood flow (1-CBF) before and after the heating of the normal monkey brain was measured. Before heating, the 1-CBF of the white matter was 18.7<plus-minus>9.8ml/100g brain/min, after heating (30ﾟC), that was increased about two hold compared with before heating. This selective increase of CBF was favorable for the chemotherapIn future, we attend to develop more effective antenna and the antenna guiding system, to investigate the change of the heated normal brain tissue from the pathological point of view and to examine the limiting point of heating the brain tissue. Less