RESEARCH FOR COMBINED THERAPY WITH INTERSTITIAL MACROWAVE HYPERTHERMIA AND INTERSTITIAL IRRADIATION FOR MALIGNANT BRAIN TUMORS

间质微波热疗和间质照射联合治疗恶性脑肿瘤的研究

• 批准号: 62870057
• 负责人: NISHIMOTO Akira
• 金额: $ 2.43万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62870057/
• 关键词: INTERSTITIAL IRRADIATION; MICROWAVE INTERSTITI; HYPERTHERMIA; BRAIN TUMOR; ^<192>Ir SEED; CT-GUIDED STEREOTACTIC SYSTEM; 放射線組織内照射; マイクロウェ-ブ組織内照射; Ir-192 seed; Ir-192Seed

1) Interstitial IrradiationTo investigate the effects of interstitial irradiation on normal brain tissue, Ir-192 seeds were stereotactically implanted into the cerebral hemisphere of adult Japanese monkeys. The effects on the brain were evaluated with neurological examination, neuroradiography and histological examination. Significant damage such as necrosis was observed on the area irradiated more than 200-260 Gy. The radiation-induced edema was most prominently observed in the acute stage and thereafter decreased gradually up to 6 months. The further researchs were necessary to determine the relative contributions of dose rate, total, dose, irradiated volume.2) Interstitial HyperthermiaThe theramal damage of normal brain tissure was estimated from the immediate and delayd histological changes caused by microwave intersititial hyperthermia. A microwave antenna within a cooling system was inserted into the cerebral hemisphere. The temperature at a reference point was maintained at 42,4 … More 3,44,45 and 46ﾟC for 60 minutes. Areas heated below 44ﾟC showed no obvious irreversible change and areas heated at 44ﾟC or above showed coagulative necrosis. Those histological findings indicate that the thermal damage occurs after at 44ﾟC or above for 60 minutes, and suggest that the safety limit for brain hyperthermia is 43ﾟC for 60 minutes.3) Clinical TrialEleven patients with recurrent or unremovable malignant brain tumors were treated by interstitial irradiation with 192Ir seeds using BRW stereotactic systems. Two patients also recieved the interstitial hyperthermia in combination with interstitial iiradiation. In one patient, the tumor had disappeard, and tumor regression was observed in 5 patients of the 11 patients. The results suggest that interstitial irradiation and hypertermia are useful for malignant brain tumors. However, in this study the small numbers and short follow-up preclude any conclusions regarding efficacy. Additional clinical and basic research should be obtained to determine the value of interstitial irradiation and hyperthermia in th treatment of malignant brain tumors. Less

1)间质照射为了研究间质照射对正常脑组织的影响，将Ir-192粒子立体定向植入成年日本猴的大脑半球。通过神经系统检查、神经影像学检查和组织学检查评价脑组织的影响。照射剂量超过200-260戈伊的区域观察到明显的损伤，如坏死。辐射引起的水肿在急性期最为显著，此后逐渐减少，直至6个月。2）间质热疗根据微波间质热疗对正常脑组织即刻和延迟的组织学改变来评价其热损伤程度。将冷却系统内的微波天线插入大脑半球。参考点的温度保持在42.4 ℃， ...更多信息 在3，44，45和46摄氏度下加热60分钟。加热至44 ℃以下的区域无明显不可逆变化，加热至44 ℃或以上的区域出现凝固性坏死。这些组织学结果表明，热损伤发生在44 ℃或以上60分钟后，并建议脑热疗的安全限值为43 ℃ 60分钟。3）临床试验11例复发或不可切除的恶性脑肿瘤患者使用BRW立体定向系统进行192 Ir粒子间质照射。2例患者还接受了组织间热疗联合组织间放疗。1例患者肿瘤消失，11例患者中有5例观察到肿瘤消退。结果提示，脑间质照射和高温治疗对恶性脑肿瘤有一定的疗效。然而，在本研究中，由于患者数量少和随访时间短，无法得出任何有关疗效的结论。应进一步开展临床和基础研究，以确定间质放疗和热疗在恶性脑肿瘤治疗中的价值。少

项目成果

Eiji Moriyama: "Hyperthermia for tumors:Improved delivery with a new cooling system" Neurosurgery. 23. 189-195 (1988)

Eiji Moriyama：“肿瘤热疗：通过新的冷却系统改善分娩”神经外科。

松海信彦: "正常脳組織の加温限界:温熱によるサル正常脳組織の組織学的変化" 岡山医学会雑誌. 101. 1049-1061 (1989)

Nobuhiko Matsumi：“正常脑组织的加热极限：由于高热导致的猴子正常脑组织的组织学变化”冈山医学会杂志 101. 1049-1061 (1989)。

A.Nishimoto: Current Research in Hyperthermia Oncology,Academic Press. 143-150 (1988)

A.Nishimoto：热疗肿瘤学的最新研究，学术出版社。

三島宣哉: 日本放射線腫瘍学会誌. 1. 20 (1989)

三岛伸哉：日本放射肿瘤学会杂志 1. 20 (1989)。

T.Satoh: "Thermal distribution studies of helical coil microwave antennae for interstitial hyperthermia" Int.J.Radi Oncol.Biol Phys. 15. 1209-1218 (1988)

T.Satoh：“用于间质热疗的螺旋线圈微波天线的热分布研究”Int.J.Radi Oncol.Biol Phys。