Amphiphilic precision macromolecules to study effects of membrane dynamics (A11#)

用于研究膜动力学影响的两亲精密大分子 (A11

• 批准号: 437206752
• 金额: --
• 依托单位: Institut für Makromolekulare Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/437206752?language=en
• 关键词: Amphiphilic; precision; macromolecules; study; effects

Within this proposal, we aim at developing a platform of synthetic amphiphiles as mimetics and modula-tors of biomembranes. Through solid phase assembly of tailor-made building blocks, structurally defined synthetic amphiphiles, so called amphiphilic precision macromolecules (AMs) can be obtained that allow analyzing the effect of a large range of structural parameters such as the geometry and composition of the hydrophilic head or hydrophobic tail group on membrane dynamics. Together with the collaboration partners within the CRC, AMs will be explored to vary membrane properties e.g. by creating crowded membrane surfaces and study the effects on membrane proteins, both in vitro and in planta.

在此提案中，我们旨在开发一个合成两亲物的平台，作为生物膜的模拟物和模量。通过固定制造的构建块的固相组装，可以获得所谓的Amphielic Precision Macromolecules（AMS）的结构定义的合成两亲物（AMS），从而可以允许分析各种结构参数的效果，例如几何形状和诸如水生精型或氢键型尾部组成的始发型尾部动态的效果。与CRC中的协作合作伙伴一起，将探索AMS到不同的膜属性，例如通过创建拥挤的膜表面并研究对体外和植物中膜蛋白的影响。