Amphiphilic precision macromolecules to study effects of membrane dynamics (A11#)

用于研究膜动力学影响的两亲精密大分子 (A11

• 批准号: 437206752
• 金额: --
• 依托单位: Institut für Makromolekulare Chemie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/437206752?language=en
• 关键词: Amphiphilic; precision; macromolecules; study; effects

Within this proposal, we aim at developing a platform of synthetic amphiphiles as mimetics and modula-tors of biomembranes. Through solid phase assembly of tailor-made building blocks, structurally defined synthetic amphiphiles, so called amphiphilic precision macromolecules (AMs) can be obtained that allow analyzing the effect of a large range of structural parameters such as the geometry and composition of the hydrophilic head or hydrophobic tail group on membrane dynamics. Together with the collaboration partners within the CRC, AMs will be explored to vary membrane properties e.g. by creating crowded membrane surfaces and study the effects on membrane proteins, both in vitro and in planta.

在这项提议中，我们的目标是开发一个合成两亲性分子的平台，作为生物膜的模拟物和调节剂。通过量身定制的构建块的固相组装，可以得到结构定义的合成两亲分子，即所谓的两亲性精密大分子(AM)，它可以分析大范围的结构参数，如亲水头部或疏水尾基的几何和组成对膜动力学的影响。将与合作伙伴一起探索AM改变膜特性，例如通过创造拥挤的膜表面，并研究在体外和植物中对膜蛋白的影响。