A study of HBV infection, drinking habits and other environmental factors in causation of primary hepatic carcinoma and liver cirrhosis.

乙型肝炎病毒感染、饮酒习惯等环境因素导致原发性肝癌及肝硬化的研究

• 批准号: 60480195
• 负责人: HIROHATA Tomio
• 金额: $ 2.05万
• 依托单位: Kyushu University (1986)Kurume University (1985)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480195/
• 关键词: primary hepatic carcinoma; liver cirrhosis; epidemiology; case control study; HB virus; smoking; drinking; 食物

The present study was initiated to investigate etiological role of various factors in causation of primary hepatic carcinoma (PHC) and liver cirrhosis (LC). Various factors selected were: hepatitis B virus (HBV) infection, past history of blood transfusion, smoking habits, drinking habits, diet, etc. A case-control approach was employed, and necessary information was secured from medical records, from examination of blood serum for HBs-Ag titer, and by interviewing subjects by trained interviewers.As a whole, 58 PHC and 81 LC patients were identified at the Kyushu University Hospital and 129 healthy controls were recruited from a health center. Fifty two PHC and 48 controls, 79 LC and 74 controls were selected from the Kurume University Hospital and its associated hospitals.The major findings, although preliminary, were as follows: 1. HBV infection showed to be a very high risk factor for both PHC and LC. Estimated relative risks among carriers as compared to non-carriers were 10-20 times for PHC and 5-15 for LC. 2. Blood transfusion was also found to be a significant risk factor for both PHC and LC. Relative risks estimated were 3.1 for PHC and 4.0 for LC at Kyushu University and 3.1 for PHC and 1.8 for LC at Kurume University. 3. Dietary habits were found to vary greatly among individuals, so that no conclusive evidence has been obtained thus far. 4. Smoking habits were also found to vary greatly among individuals and no conclusive analysis has been made as yet. 5. The role of consumption of alcoholic beverage is an interesting subject. Data from Kyushu University indicate that patients of both PHC and LC consumed more alcoholic beverage than did controls. However, conclusive results should be obtained by continuation of the study and further analysis.

本研究旨在探讨各种因素在原发性肝癌（PHC）和肝硬化（LC）发病中的作用。选定的各种因素是：乙肝B病毒（HBV）感染、既往输血史、吸烟习惯、饮酒习惯、饮食等。采用病例对照方法，从病历、血清HBsAg滴度检查和由训练有素的访谈者访谈中获得必要的信息。总体而言，在九州大学医院确定了58名PHC和81名LC患者，并从健康中心招募了129名健康对照。从库尔斯克大学医院及其附属医院中选择了52例PHC和48例对照，79例LC和74例对照。HBV感染是PHC和LC的一个非常高的危险因素。携带者与非携带者相比的估计相对风险为PHC的10-20倍和LC的5-15倍。2.输血也被发现是一个显着的危险因素，为PHC和LC。九州大学估计的相对危险度分别为PHC 3.1和LC 4.0，Kuryang大学估计的相对危险度分别为PHC 3.1和LC 1.8。3.人们发现饮食习惯因人而异，因此迄今为止还没有获得确凿的证据。4.此外，研究亦发现吸烟习惯在不同人士之间有很大差异，但至今仍未有结论性的分析。5.酒精饮料消费的作用是一个有趣的话题。九州大学的数据表明，PHC和LC患者比对照组消耗更多的酒精饮料。然而，结论性结果应通过继续研究和进一步分析获得。