Diagnosis and evaluation of hepatocellular carcinoma and precancerous states using magnetic resonance imaging

磁共振成像对肝细胞癌及癌前状态的诊断和评估

• 批准号: 60480254
• 负责人: ITAI Yuji
• 金额: $ 4.22万
• 依托单位: University of Toky,Faculty of Medicine.
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480254/
• 关键词: MRI; Hepatocellular carcinoma; Liver cirrhosis; Regeneration nodules; Tumor thrombus; Woodchuck; MRI造形剤; MRI(核磁気共鳴CT); 肝硬変

1.Diagnosis of hepatocellular carcinoma; Magnetic resonance imaging(MRI) was as effective as conventional CT in the evaluation of hepatocellular carcinoma(HCC). Differentiation of HCC from cavernous hemangioma was accurate in over 90% by measurement of transverse relaxation time(T2).2. Pathophysiology of HCC and precancerous states; MRI either on T2-weighted- or gradient echo image could detect regenerating nodules of liver cirrhosis (high risk state for HCC) as innumerable tiny low intensity nodules. It is useful not only in the differential diagnosis from tiny HCC(always high-intensity on T2-weighted image,if detected) but also in the evaluation and observation of liver cirrhosis. HCC often causes portal vein obstruction either by tumor thrombus or by direct compression. Peripheral zone distal to portal obstruction appeared as high intensity area on T2-weighted image due to secondary change of portal blood flow stoppage.3.Contrast agent; Dynamic MRI using gadolinium-DTPA was applied in liver tumors, where cavernous hemangioma showed prolonged,marked enhancement and was easily differentiated form HCC.

1.肝细胞癌的诊断：磁共振成像（MRI）在评价肝细胞癌（HCC）方面与常规CT一样有效。横向弛豫时间（T2）的测定对HCC与海绵状血管瘤的鉴别诊断准确率在90%以上. HCC和癌前状态的病理生理学; T2加权或梯度回波图像上的MRI可以检测到肝硬化（HCC的高危状态）的再生结节为无数微小的低强度结节。它不仅适用于与微小肝癌（如果检测到，T2加权图像上总是高信号）的鉴别诊断，而且适用于肝硬化的评估和观察。肝癌常因癌栓或直接压迫门静脉而引起门静脉阻塞。由于门脉血流阻塞的二次变化，门脉阻塞远端的外周区在T2加权像上出现高信号区。3.造影剂;肝脏肿瘤采用钆-DTPA动态MRI，海绵状血管瘤呈延长、明显强化，易于与肝癌鉴别。

项目成果

大友邦, その他: 画像診断. 6. 855-857 (1986)

Kuni Otomo，其他：影像诊断。6. 855-857 (1986)。

Itai,Y, Ohtomo,K, Furui,S, Minami,M, Yoshikawa,K, Yashiro,N.: "MR imaging of hepatocellular carcinoma." Comput Assist Tomogr.10. 963-968 (1986)

Itai,Y, Ohtomo,K, Furui,S, Minami,M, Yoshikawa,K, Yashiro,N.：“肝细胞癌的磁共振成像。”

Ohtomo,K, Itai,Y, Makita,K, Yshiro,N, Yoshikawa,K, Kokubo,T, Iio,M.: "Portosystemic collaterals on MR imaging." Comput Assist Tomogr.10. 751-755 (1986)

Ohtomo,K, Itai,Y, Makita,K, Yshiro,N, Yoshikawa,K, Kokubo,T, Iio,M.：“MR 成像上的门体循环。”

Ohnishi S, Aoyama H, Shiga J, Itai Y, Moriyama T, Ishikawa T, Sasaki N, Yamamoto K, Koshimizu S, Kaneko S, Murakami S, Hattori N, Imawari M.: "Establishment of a new cell line from a woodchuck hepatocellular carcinoma." Hepatology. 8. (1988)

Ohnishi S、Aoyama H、Shiga J、Itai Y、Moriyama T、Ishikawa T、Sasaki N、Yamamoto K、Koshimizu S、Kaneko S、Murakami S、Hattori N、Imawari M.：“从土拨鼠中建立新细胞系

Ohtomo K. et al.: J Comput Assist Tomogr.10. 751-755 (1986)

Ohtomo K. 等人：J Comput Assist Tomogr.10。