Immunological Research on Intractable Diseases of the Oral Mucosa

口腔粘膜疑难杂症的免疫学研究

• 批准号: 60480428
• 负责人: FUJIBAYASHI Takashi
• 金额: $ 3.26万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-60480428/
• 关键词: Diseases of the Oral Mucosa; Intactable diseases; Immunological researches; Recurrent aphthous ulcers; Lichen planus; Sjogren's disease; Leukoplakia; 白板症

Clinical and immunological researches have been performed on various diseases of the oral mucosa in order to study what kind of factors are concerned with intractable change or malignant transformation of the diseases.Recurrent aphthous ulcers were classified in three clinical types; minor aphthous ulcers (MiAU), major aphthous ulcers (MjAU), and herpetiform ulcers (HU). MiAU was most common, however, MjAU which consist of about 25% of all cases mostly included intractable cases of recurrent aphthous ulcers. MjAU was more frequent in Behcet's diseases. Intractable oral lichen planus was mostly found in erosive type. Immunofluorescent study was useful in differential diagnosis of the disease. Immunoperoxidase method revealed prominence of OKT-6 positive Langerhans cells in basal cell layer and OKT-8 positive T lymphocytes in subepithelial layer of oral lichen planus.In Sjogren's disease, salivary gland scintillation radiography was quite useful in clinical stage analysis of the disease. Immunological study exhibited some serum autoantibodies including antinuclear antibody, anti-DNA antibody, anti SS-A antibody, and tendency of polyclonal B cell hyperplasia. Further studies including the disease sensitivity analysis based on HLA typing would be requested.Histolical case protocall analysis on oral leukoplakia revealed that 11 lesions out of 260 lesions in 198 patients showed malignant transformation after average duration of 5 years 5 months. Speckled type leukoplakia of the tongue even with or without histological epithelial dysplasia can be considered as relatively high risk group to go malignant.Pemphigus and benign mucous membrane pemphigoid were studied by immunofluorescent histopathology. Direct immunofluorescent method was quite useful in differential diagnosis, and indirect method detecting serum antibody titers was also devoted in diagnosing further clinical courses of the patients.

复发性阿弗他溃疡（Recurrent aphthous ulcers，RUC）分为3种临床类型：轻度阿弗他溃疡（minor aphthous ulcers，MiAU）、重度阿弗他溃疡（major aphthous ulcers，MjAU）和疱疹样溃疡（herpetiform ulcers，HU）。MiAU是最常见的，然而，MjAU（占所有病例的约25%）主要包括复发性阿弗他溃疡的难治性病例。MjAU在白塞病中更常见。难治性口腔扁平苔藓多见于糜烂型。免疫荧光检查有助于本病的鉴别诊断。免疫过氧化物酶法显示口腔扁平苔藓基底细胞层OKT-6阳性郎格罕细胞和上皮下OKT-8阳性T淋巴细胞明显增多。免疫学检查显示有抗核抗体、抗DNA抗体、抗SS-A抗体等血清自身抗体，并有多克隆B细胞增生的趋势。对198例口腔白斑患者260个皮损中11个发生恶变，平均病程5年5个月。舌部斑点型白斑，无论有无组织学上皮异常，均可认为是恶变的高危人群。采用免疫荧光组织病理学方法对天疱疮和良性粘膜类天疱疮进行了研究。直接免疫荧光法在鉴别诊断中有很大的价值，间接法检测血清抗体滴度也有助于进一步诊断患者的临床病程。

项目成果

Takashi FUJIBAYASHI: "Malignant tumors - oral cancer and immunology -" The Journal of the Japan Dental Association. 39. 257-266 (1986)

Takashi FUJIBAYASHI：“恶性肿瘤 - 口腔癌和免疫学 -” 日本牙科协会杂志。

Takashi FUJIBAYASHI: "Oral leukoplakia and its malignant change" Medical Immunology. 11. 247-248 (1986)

Takashi FUJIBAYASHI：“口腔白斑及其恶变”医学免疫学。

Takashi FUJIBAYASHI: "Immunology of the diseases of the oral mucosa" The Journal of the Japan Dental Association. 39. 697-710 (1986)

Takashi FUJIBAYASHI：“口腔粘膜疾病的免疫学”日本牙科协会杂志。

Junichi SHINDO, Takashi FUJIBAYASHI, Tamio NAKAJIMA: Shorin. Disease atlas in clinics of oral and maxillo-facial surgery, 217 (1986)

新藤纯一、藤林隆、中岛民雄：少林。

Takashi FUJIBAYASHI: "Recurrent aphtha and immunology" Medical Immunology. 12. 845-846 (1986)

Takashi FUJIBAYASHI：“复发性口疮与免疫学”医学免疫学。