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Research on diagnostic criteria for xerostomia

口干症诊断标准的研究

基本信息

批准号：
18390547
负责人：
FUJIBAYASHI Takashi
金额：
$ 5.38万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390547/
关键词：
xerostomia diagnostic criteria Sjogren's syndrome salivary secretion rate labial salivary gland histopathology Moisture Checker salivary gland scintigraphy MR-sialography MR sialogarAhy 唾液粘度

项目摘要

The following clinical research has been carried out with those patients who visited our hospital with chief complaint of dry mouth, or who have possibility of Xerostomia or Sjogren's syndrome (SS) even though they may not necessarily have complaint of dry mouth, or who have already confirmed diagnosis of Xerostomia or Sjogren's syndrome but considered to be necessary to have clinical examinations during their clinical courses at the specialized clinic of dry mouth. The analysis was performed to collected materials from 78 patients consisted by 29 SS patients and 49 nonSS patients.1) Subjective symptom of dry mouth, 2) Objective symptom of dry mouth, 3) Sialometry of stimulated whole saliva: 3-(1) chewing gum test, 3-(2) Saxon's test by sponge gauze. 4) Salivary gland scintigraphy: the areas of interest were settled on bilateral parotid glands and submandibular glands. Time activity curves (TAC) were drawn and both accumulation rate and secretion rate were calculated. 5) MR-sialography … More were examined and analyzed. 6) Quantitative analysis of histopathology of labial minor salivary gland biopsy: Several numbers of labial glands were taken out for histopathological analysis for counting focus number of periductal infiltrating lymphocytes with more than 50 cells per 4 square mm of labial gland area. In addition, the degree of fatty change and fibrosis has been also evaluated. Total dimension of labial glands, dimension of each single gland, dimension of focus, number of lymphocytes in each focus have been counted using microscopic image analyzer. 7) Examination of wetness of the oral mucosa by Moisture Checker. 8) Viscosity of the saliva was calculated by ultrasonic viscosity meter of Viscostick by getting patients saliva by gently spitting into the test tube. 9) Summary of these results reconsidered in making a new classification criterion of xerostomia proposed by Japanese Society of Oral Mucous Membrane. 10) Accuracy of this new criterion in diagnosing xerostomia was investigated by using the collected materials. Less

以下临床研究是针对以下患者进行的：以口干为主诉来我院就诊的患者，或有可能患有口干或干燥综合征（SS）的患者，尽管他们可能不一定有口干的主诉，或已经确诊为口干或干燥综合征，但被认为有必要在口干专科诊所的临床课程中进行临床检查的患者。对78例患者的资料进行分析，其中29例SS患者和49例非SS患者。1)主观口干症状，2)客观口干症状，3)刺激全唾液唾液量测定：3-(1)口香糖试验，3-(2)海绵纱布撒克逊试验。4)唾液腺闪烁成像：目标区域确定在双侧腮腺和下颌下腺。绘制时间活性曲线（TAC），计算积累率和分泌率。更多的人接受了检查和分析。6)唇小唾液腺活检组织病理学定量分析：取数个唇腺进行组织病理学分析，计数每4平方mm唇腺面积≥50个细胞的管周浸润淋巴细胞病灶数。此外，还评估了脂肪变化和纤维化的程度。用显微图像分析仪对唇腺的总尺寸、单个腺的尺寸、病灶的尺寸、各病灶的淋巴细胞数量进行计数。7)用Moisture Checker检查口腔黏膜的湿润度。8)用Viscostick公司的超声波粘度计计算唾液的粘度，将患者唾液轻轻吐入试管中。9)对日本口腔粘膜学会提出的口干病新分类标准进行综合分析，并对新分类标准诊断口干病的准确性进行探讨。少