STUDIES ON INTRACTABLE ORAL MUCOSAL LESIONS
难治性口腔粘膜病变的研究
基本信息
- 批准号:07407057
- 负责人:
- 金额:$ 6.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1995
- 资助国家:日本
- 起止时间:1995 至 1998
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. Immunological investigation on intractable oral mucosal lesions with special focus on oral mucosal cancers The cytotoxic activities of anti-CD3 induced LAX ceUs were sbicied with oral scwmous cell carcinoma derived target cells after preincubation with chemotherapeutic reagents such as CDDP, 5FU, PEP, BLM.The cytotoxic activity varied with reagent applied, HLA class I, II expression also showed some variations.2. lrrvestigation on immunological response through coslimulatory molecules in intractable oral , mjcosal lesions Mouse model of hapten induced contact dermatitis were studied. Strong increase of CD86 expression on Langerharis cells and some increase of CD8O, CD86 both positive cells were observed after skin sensitization. The skin reaction was depressed by ackninistration of anti-CTLA-4 antibody.3. Investigation on prognosis of intractalAe oral mucosal lesions Multivariate evaluation of prognostic determinant factors for oral squamous cell carcinomas using Cox'proportional ha … More zards model revealed that pattern of invasion in histopathology, T classification, treatment modality were most significant prognostic factors. Other oral mucosal lesions such as oral precancerous lesions like oral letkoplakia, oral precancerous condition related lesions like oral lichen planus were also studied.4. Investigation on clinical features of intractable oral mucosal lesions Clinical featres of Siogrerfssynch-ome and xerostomia were mostly investigated. Diagnostic criteria for Siogren's syndrome play key role for differential diagnosis of the both diseases. Head investigator attended working cornmrttee for revision of Jaanese diagnosbc cnteria in Japanese Association for Sjogren's Synckome. Total number of 823 cases of Siogren's synciome inducing normal control was assayed for sensitivity and specificity in diagnosis using various revised criteria. Final revised diagnostic criterion for Siogreri's syndome has completed through discussion in Japanese Association for Sjogren's syndrome. Less
1.口腔黏膜癌难治性病变的免疫学研究抗CD 3诱导的LAX细胞对口腔鳞癌靶细胞的细胞毒活性检测结果显示,抗CD 3诱导的LAX细胞对口腔鳞癌靶细胞的细胞毒活性随化疗药物的不同而不同,HLA I、II类分子的表达也有一定的差异.共刺激分子在口腔粘膜难治性病变中的免疫应答研究皮肤致敏后郎格哈里斯细胞表面CD 86表达明显增加,CD 80、CD 86双阳性细胞也有一定程度的增加。抗CTLA-4抗体的联合应用可抑制皮肤反应.口腔黏膜内病变预后的探讨考克斯比例风险分析法对口腔鳞癌预后影响因素的多因素分析 ...更多信息 Zards模型显示组织学浸润方式、T分期、治疗方式是影响预后的重要因素。其他口腔粘膜病变如口腔白斑等口腔癌前病变、口腔扁平苔藓等口腔癌前病变相关病变也进行了研究.难治性口腔黏膜病变的临床特点探讨主要探讨了口腔黏膜干燥症和唾液分泌异常的临床特点。Siogren综合征的诊断标准对两者的鉴别诊断具有重要意义。主要研究者参加日本干燥综合征协会日本诊断标准修订工作会议。本文对823例Siogren综合征诱发正常人作了诊断的敏感性和特异性分析。通过日本干燥综合征协会的讨论,最终修订的Siogreri综合征诊断标准已经完成。少
项目成果
期刊论文数量(48)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
藤林孝司: "歯科におけるくすりの使い方" デンタルダイアモンド社, 316 (1995)
Takashi Fujibayashi:“如何在牙科中使用药物”Dental Diamond Co., Ltd.,316(1995)
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takashi Fujibayashi: "Immunotherapy of cancer." Dental Outlook. 88-6. 1363-1372 (1996)
藤林隆:“癌症的免疫疗法。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takashi Fujibayashi: "Drug therapy of oral lichen planus." The Journal of Practical Pharmacy. 48-6. 891-897 (1997)
Takashi Fujibayashi:“口腔扁平苔藓的药物治疗。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Takashi Fujibayashi: "A review of recent studies on Sjogren's syndrome." Journal of Japanese Society for Oral Mucous Membrane. 4-2. 75-90 (1998)
Takashi Fujibayashi:“干燥综合征近期研究综述。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
藤林 孝司: "口腔扁平苔癬の薬物療法" 薬局. 48・6. 891-897 (1997)
藤林隆:“口腔扁平苔藓的药物治疗”药理学48・6(1997)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
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FUJIBAYASHI Takashi其他文献
FUJIBAYASHI Takashi的其他文献
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{{ truncateString('FUJIBAYASHI Takashi', 18)}}的其他基金
Research on diagnostic criteria for xerostomia
口干症诊断标准的研究
- 批准号:
18390547 - 财政年份:2006
- 资助金额:
$ 6.34万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
IMMUNOBIOLOGICAL STUDIES ON ORAL LESION OF SJOGREN'S SYNDROME
干燥综合征口腔病变的免疫生物学研究
- 批准号:
12470448 - 财政年份:2000
- 资助金额:
$ 6.34万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A STUDY ON IMMUNOTHERAPY OF ORAL CANCERS
口腔癌免疫治疗的研究
- 批准号:
04404077 - 财政年份:1992
- 资助金额:
$ 6.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
Studies on DEVELOPMENT OF ImMUNOTHERAPY FOR ORAL CANCERS BY INTERLEUKIN 2
白细胞介素2免疫治疗口腔癌的研究进展
- 批准号:
60870071 - 财政年份:1985
- 资助金额:
$ 6.34万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
Immunological Research on Intractable Diseases of the Oral Mucosa
口腔粘膜疑难杂症的免疫学研究
- 批准号:
60480428 - 财政年份:1985
- 资助金额:
$ 6.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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