Acute and Chronic Responses of Pancreatic Exocrine Protease Secretion to Different Dietary Proteins and Oligomethionine in Rats

大鼠胰腺外分泌蛋白酶分泌对不同膳食蛋白和低聚蛋氨酸的急、慢性反应

基本信息

  • 批准号:
    61480055
  • 负责人:
  • 金额:
    $ 3.52万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 财政年份:
    1986
  • 资助国家:
    日本
  • 起止时间:
    1986 至 1987
  • 项目状态:
    已结题

项目摘要

1.Acute effects of dietary proteins on the rate of oligomethionine digestion associated with pancreatic exocrine protease secretion: When 8% casein (8C) diet was supplemented with 0.3% oligomethionine (a mixture of hexa-and hepta-peptides, abbreviated as OM) weanling rats grew at the same rate as that attained with Met-supplemented diet. When OM was supplemented to 10% soybean protein isolate (10S) diet, however, little or no growth promotion was observed.Met concentration of the portal blood plasma from fasting rats refed 8C+30M was significantly higher than that of rats refed 8C, 10S, 10S+30M, irrespective of prefed dietary proteins. Increment of portal Met concentration in fasting rats refed different protein diets containing 30M was high in the order of the following diets; scallop, rice, hluten, tuna, salmon, peanut, potato and cod. On the supplementation of OM to a low potato or cod diet, the weight gain in rats was lower than that of rats fed the Met-supplemented diet. On the other hand, supplementation of OM to a low gluten, tuna or peanut diet increased significantly the growth of rats as compared with that of the basal diet-fed rats. Also, the different effect of OM supplemented to gluten, the enzyme hydrolysate or amino acid mixture diet agreed very closely with the result of portal Met increment from rats refed these diets containing 30M.2.Adaptive increase in pancreatic proteases and OM-digestion due to chronic ingestion of OM: When rats prefed 8C, 8C+30M for 2 weeks, pancreatic carboxypeptidase activity was higher in rats fed OM-containing diet. Only the rats previously consumed OM showed a significantly higher Met concentration in the portal blood in response to refeeding the OM-containing diet.
1.膳食蛋白质对与胰腺外分泌蛋白酶分泌相关的寡聚蛋氨酸消化速率的急性影响:当8%酪蛋白(8C)饮食补充0.3%寡聚蛋氨酸(六肽和七肽的混合物,缩写为OM)时,断奶大鼠的生长速率与补充Met的饮食相同。在10%大豆分离蛋白(10S)饲料中添加OM对生长无明显促进作用,禁食8C+30M组大鼠门静脉血浆Met浓度显著高于8C、10S、10S+30M组,且与饲料蛋白质无关。禁食大鼠门静脉蛋氨酸浓度的增加以扇贝、大米、鲱鱼、金枪鱼、鲑鱼、花生、马铃薯和鳕鱼的顺序为高。在低马铃薯或鳕鱼饮食中补充OM时,大鼠的体重增加低于喂食Met补充饮食的大鼠。另一方面,与基础饲料喂养的大鼠相比,在低面筋、金枪鱼或花生饲料中补充OM显著增加了大鼠的生长。2.长期摄入OM使胰腺蛋白酶和OM消化适应性增加:在8C、8C+30M预喂2周时,胰腺羧肽酶活性高于对照组。只有大鼠先前消耗OM显示出显着较高的蛋氨酸浓度在门静脉血中的响应重新喂养OM含饮食。

项目成果

期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Shunachi,Kiriyama: "Acute and Chronic Responses of Pancreatic Exocrine Carboxypeptidase A Secretion to Different Dietary Proteins and Oligomethionine in Rats" Nutr. Sci. Soy Protein, Jpn.7. 35-40 (1986)
Shunachi,Kiriyama:“大鼠胰腺外分泌羧肽酶 A 分泌对不同膳食蛋白质和寡甲硫氨酸的急性和慢性反应”Nutr。
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桐山修八: 大豆たん白質栄養研究会会誌. 7. 35-40 (1986)
Shuhachi Kiriyama:《大豆蛋白营养研究会杂志》,7. 35-40 (1986)。
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知地英征: J.Nutr.(1987)
地地秀吉:J.Nutr.(1987)
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    0
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Shuhachi,Kiriyama: "Differential Inducibility of Threonine Imbalance of L-Methionine and Oligo-L-methionine Supplemented to A 8% Casein or 10% Soy protein Isolate Diet in Rats" Nutr. Sci. Soy Protein, Jpn.5. 31-37 (1984)
Shuhachi, Kiriyama:%20"差异%20诱导性%20of%20苏氨酸%20不平衡%20of%20L-蛋氨酸%20和%20低聚-L-蛋氨酸%20补充%20至%20A%208%%20酪蛋白%20或%2010%%20大豆%20蛋白质
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    0
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桐山修八: 大豆たん白質栄養研究会会誌. 8. 59-63 (1987)
Shuhachi Kiriyama:《大豆蛋白营养研究会杂志》,8. 59-63 (1987)。
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KIRIYAMA Shuhachi其他文献

KIRIYAMA Shuhachi的其他文献

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{{ truncateString('KIRIYAMA Shuhachi', 18)}}的其他基金

Regulatory Mechanism of Plasma Cholesterol Concentration by Dietary Protein : Evidence that plasma cholesterol is not regulated by modification of entero-hepatic circulation of steroids.
膳食蛋白质对血浆胆固醇浓度的调节机制:证据表明血浆胆固醇不受类固醇肠肝循环改变的调节。
  • 批准号:
    63480053
  • 财政年份:
    1988
  • 资助金额:
    $ 3.52万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
The site of the interaction between dietary fiber and the small intestine and its nutritional significance in rats fed excessive doses of Food Red No. 2.
过量食用食红2号大鼠膳食纤维与小肠相互作用的部位及其营养意义。
  • 批准号:
    59480054
  • 财政年份:
    1984
  • 资助金额:
    $ 3.52万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

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