Evaluation of pancreatic exocrine secretion using ^<13>C-dipeptide (benzoyl-L-tyrosyl-[1-^<13>C]alanine) breath test

使用^ 13 C-二肽（苯甲酰基-L-酪氨酰-[1-^ 13 C]丙氨酸）呼气试验评估胰腺外分泌分泌

• 批准号: 16590640
• 负责人: ISHII Yukimoto
• 金额: $ 2.3万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590640/
• 关键词: ^<13>C; breath test; pancreas; pancreatic exocrine function; 膵臓外分泌障害; 膵外分泌機能; 慢性膵炎; PFD tes

Objective : We investigated whether a breath test using benzyl-L-tyrosyl-[1-^<13>C]alanine (Bz-Tyr-Ala) allows assessment of pancreatic exocrine function. Methods and Subjects : Bz-Tyr-Ala was orally administered, and changes in ^<13>CO_2 were expressed as Δ‰. The breath test was performed in chronic pancreatitis patients and healthy subjects in a preliminary study, and subsequently in 17 pancreatoduodenectomy patients, to examine the difference between the results obtained at the times of pancreatic tube insertion and removal, the relationship between breath test results after tube removal and the volume of pancreatic juice drained, and the difference in results between the presence versus the absence of histological changes of chronic pancreatitis. Results : The Δ‰ was lower in the chronic pancreatitis patients than in healthy subjects. In the postoperative patients, the Δ‰ was higher at tube insertion than at tube removal. The correlations of the Δ‰ with the maximum volume of pancreatic juice, its mean volume, and pancreatic juice amylase levels were 0.865, 0.757 and 0.853, respectively. The Δ‰ was lower in 11 patients with than in 6 patients without histological changes of chronic pancreatitis. Conclusion : These results suggest that the Bz-Tyr-Ala breath test can measure pancreatic exocrine function.

目的：研究使用苄基- l-酪氨酸-[1-^<13>C]丙氨酸（Bz-Tyr-Ala）呼气试验是否可以评估胰腺外分泌功能。方法和对象：口服Bz-Tyr-Ala， ^<13>CO_2变化表示为Δ‰。在初步研究中，对慢性胰腺炎患者和健康受试者进行呼吸测试，随后对17例胰十二指肠切除术患者进行呼吸测试，以检查插入和拔出胰管时获得的结果的差异，拔出胰管后呼吸测试结果与排出胰液量的关系，以及存在与不存在慢性胰腺炎组织学改变的结果的差异。结果：慢性胰腺炎患者的Δ‰低于健康人。术后患者中，插管时的Δ‰高于拔管时。Δ‰与最大胰液容积、平均胰液容积和胰液淀粉酶水平的相关性分别为0.865、0.757和0.853。11例慢性胰腺炎患者的Δ‰低于6例无组织学改变的患者。结论：Bz-Tyr-Ala呼气试验可测量胰腺外分泌功能。

项目成果

A simple extra-pancreatic secretory function test by a ^<13>C-dipeptide breath test (in Japanese).

通过^ 13 C-二肽呼吸测试进行简单的胰外分泌功能测试(日语)。

• 发表时间: 2004
• 期刊: Gastroentelogy(Tokyo) 39(2)
• 作者: Yukimoto Ishii;Tadatoshi Takayama;Satoshi Asai
• 通讯作者: Satoshi Asai

Evaluation of Pancreatic Exocrine Secretion Using 13C-Dipeptide (Benzoyl-L-Tyrosyl-[1-13C]Alanine) Breath Test: Focusing on Pancreatoduodenectomy Cases

使用13C-二肽（苯甲酰-L-酪氨酰-[1-13C]丙氨酸）呼气试验评价胰腺外分泌分泌：以胰十二指肠切除术病例为重点

• 发表时间: 2007
• 期刊: Pancreas
• 影响因子: 2.9
• 作者: Y. Ishii;T. Kohno;A. Ito;Shigeru Suzuki;T. Kohno;T. Takayama;S. Asai
• 通讯作者: S. Asai

Measurement of extra-pancreatic secretory function by a ^<13>C-dipeptide breath test.

通过13 C-二肽呼吸测试测量胰腺外分泌功能。

• 期刊: Translational Research (J LAB CLIN MED) (in press)
• 作者: Yukimoto Ishii;Tadatoshi Takayama;Satoshi Asai
• 通讯作者: Satoshi Asai

^<13>C-ジペプチド(Benzoyl-L-Tyrosyl-[1-^<13>C]alanine)呼気テストによる簡易膵外分泌機能検査法

^<13>C-二肽（苯甲酰-L-酪氨酰-[1-^<13>C]丙氨酸）使用呼气试验的简单外分泌功能测试方法

• 发表时间: 2004
• 期刊: 消化器科 39・2
• 作者: 石井敬基;高山忠利;浅井聡他
• 通讯作者: 浅井聡他

Evaluation of pancreatic exocrine secretion using ~<13>C-depeptide(benzoyl-L-tyrosyl-[1-~<13>C]alanine) breath test : Focusing on pancreatoduodenectomy cases

使用～<13>C-肽（苯甲酰基-L-酪氨酰-[1-～<13>C]丙氨酸）呼气试验评价胰腺外分泌分泌：以胰十二指肠切除术病例为中心

• 期刊: Pancreas (in press)
• 作者: Yukimoto Ishii;Tadatoshi Takayama;Satoshi Asai.
• 通讯作者: Satoshi Asai.