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Eustachian tube and middle ear diseases

咽鼓管和中耳疾病

基本信息

批准号：
61480357
负责人：
HONJO Iwao
金额：
$ 3.26万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-61480357/
关键词：
Eustachian tube Eustachian tube function Otitis media 真珠腫

项目摘要

Patients in the convalescent stage of otitis media with effusion (OME) were not able to dissolve negative pressure loded in the middle ear, which was considered to be predisposing eustachian tube dysfunction in the patients oh OME. HOwEVER. transection of tensor veli palativi nuscle in cat brought about only -200mmH_2O in the middle ear, which was not sufficient for the production of middle ear effusion. Not only eustachian tube dysfunction but also production of fluid by inflammatory process were considered to be necessary for fhe envelopment of OME. Also, negative middle ear pressure and earbrum restraction were found to inflnence inner ear function causing temporary sensorineural hearing loss or disequilibrium. Further investigaion on inner ear dysfunction caused by middle ear diseases was considered to be encessary.Sonotubometry with middle ear peedssue loading developed in this study was found to be a useful method for detectinh closing failure og the eustachian tube, Which was frequently found in patients with cleft palate and middle ear cholesteatoma. Not an organic stenosis of the eustachian tube but the impairment of its active ventilatory function was found frequently in patients with OME, chronic otitis media and cholesteatoma. Among preoperative eustachian tube function tests performed in this study, results of positive pressure test correlated with the outcome of tympanoplasty. Efficacy of adenoidectomy as a treatment of OME was confirmed in a large series. In addition, efficacy of transtympanic iontophoresis, a new method for the freatment of ome, was also confirmed in this study.

中耳炎伴积液恢复期患者不能溶解中耳负压，认为这是中耳炎伴积液患者咽鼓管功能障碍的易感性。然而。横断猫的腭张肌仅在中耳产生-200mmH_2O，不足以产生中耳积液。不仅咽鼓管功能障碍，而且炎症过程中液体的产生被认为是OME包膜的必要条件。此外，中耳负压和耳膜收缩也会影响内耳功能，导致暂时性的感音神经性听力损失或不平衡。对中耳疾病引起的内耳功能障碍的进一步研究是必要的。本研究所建立的中耳超声管计是检测腭裂合并中耳胆脂瘤患者常见的咽鼓管闭合失败的有效方法。在OME、慢性中耳炎和胆脂瘤患者中，常发现咽鼓管主动通气功能受损，而非器质性狭窄。在本研究进行的术前咽鼓管功能检查中，正压试验的结果与鼓室成形术的结果相关。腺样体切除术作为一种治疗OME的疗效在大量的系列研究中得到证实。此外，本研究也证实了经腹膜离子导入治疗ome的新方法的疗效。