Regulation of secretion of growth hormone, somatomedin-C and pancreatic hormones by amino acids in ruminants.

反刍动物中氨基酸对生长激素、生长调节素-C 和胰腺激素分泌的调节。

• 批准号: 62480077
• 负责人: SASAKI Yasuyuki
• 金额: $ 3.58万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480077/
• 关键词: Amino acids; Growth hormone; Somatomedin-C; Insulin; Glucagon; Ruminants

Much attention has recently been Paid to the effects of the exogenous administration of GH in increasing milk production of dairy cows. The effect of GH could involve the stimulation of catabolism of absorbed nutrients providing energy-yielding substrates for the maffimary gland and substrates that can be utilized to produce milk constituents. When energy partition in the body is directed towards catabolism. one may expect an enhanced milk production via increased substrate supply to the mammary gland. By contrast. an anabolic energy partition appears to be desirable to stimulate beef production. In ruminant animals, as in the other species, the direction of energy partition toward catabolism or anabolism is mostly regulated by metabolic hormones such as GH, somatomedin-C (Sm-C), insulin and glucagon.Several amino acids are known to affect the secretion of metabolic hormones. As these hormones are also central to the regulation of amino acid metabolism, it is worthwhile to quantify the … More extent to which each amino acid can stimulate the secretion of these hormones.Leucine was the most effective amino acid in stimulating insulin secretion but did not produce any increase in glucagon and GH secretion. Alanine, glycine and serine induced a greater enhancement of both glucagon and insulin secretion than other amino acids. No amino acid was able to specifically stimulate glucagon secretion without also increasing insulin or GH secretion. As regards insulin and glucagon secretion, amino acids could be divided into groups according to their R-structures. Neutral straight chain amino acids stimulated both insulin and glucagon secretion, with a greater secretory response to shorter C-chain amino acids. Branched chain amino acids tended to enhance insulin and suppress glucagon secretion. Acidic amino acids caused an increase in GH secretion. Aspartic acid caused the strongest stimulation of GH secretion, exceeding that induced by arginine. Prolonged intraduodenal administration of leucine enhanced Sm-C secretion. Less

近年来，外源性GH对奶牛产奶量的影响引起了人们的广泛关注。生长激素的作用可能涉及刺激吸收的营养物质的分解，为乳腺提供产生能量的底物和可用于生产乳成分的底物。当体内的能量分配指向催化剂时。可以预期通过增加对乳腺的底物供应来提高产奶量。相比之下。合成代谢能量分配似乎是刺激牛肉生产所希望的。反刍动物和其他动物一样，能量分配的方向主要受代谢激素如GH、生长调节素-C（Sm-C）、胰岛素和胰高血糖素的调节，已知有几种氨基酸影响代谢激素的分泌。由于这些激素也是调节氨基酸代谢的中心，因此值得量化这些激素的水平。 ...更多信息 亮氨酸是刺激胰岛素分泌最有效的氨基酸，但对胰高血糖素和GH分泌没有任何增加作用。丙氨酸、甘氨酸和丝氨酸诱导的胰高血糖素和胰岛素分泌的增强作用大于其他氨基酸。没有氨基酸能够特异性刺激胰高血糖素分泌而不增加胰岛素或GH分泌。至于胰岛素和胰高血糖素分泌，氨基酸可以根据它们的R-结构分成组。中性直链氨基酸刺激胰岛素和胰高血糖素分泌，对较短C链氨基酸的分泌反应更大。支链氨基酸倾向于增强胰岛素和抑制胰高血糖素分泌。酸性氨基酸引起GH分泌增加。天冬氨酸引起的GH分泌的最强刺激，超过精氨酸诱导。十二指肠内长期给予亮氨酸可增强Sm-C的分泌。少

项目成果

久原徹哉: "メンヨウの膵内分泌および成長ホルモン分泌に及ぼすGly,Leu,Aspの静脈内注入の影響" 第81回日本畜産学会大会講演要旨. 41 (1989)

Tetsuya Kuhara：“静脉注射甘氨酸、亮氨酸和天冬氨酸对肾胰腺内分泌分泌和生长激素分泌的影响”日本动物学会第 81 届年会摘要 41（1989）。

Kuhara T.: "Effects of prolonged intraduodenal administration of amino acids on the secretion of glucagon, insulin, growth hormone and IGF-I in sheep (in Japanese)" 81st Annual Meeting program-handbook of Jpn.Soc.Zootech.Sci., 1990.

Kuhara T.：“延长十二指肠内施用氨基酸对绵羊胰高血糖素、胰岛素、生长激素和 IGF-I 分泌的影响（日语）”第 81 届年会议程 - Jpn.Soc.Zootech.Sci. 手册，

Kuhara T.: "Effects of intravenous infusion of seventeen amino acids on the secretion of GH,glucagon and insulin in sheep" Am.J.Physiol.

Kuhara T.：“静脉输注十七种氨基酸对绵羊 GH、胰高血糖素和胰岛素分泌的影响”Am.J.Physiol。

Kuhara T.: "Effects of intravenous infusion of seventeen amino acids on the secretion of GH,glucagon and insulin in sheep" Am.J.Physiol(投稿中).

Kuhara T.：“静脉输注十七种氨基酸对绵羊 GH、胰高血糖素和胰岛素分泌的影响”Am.J.Physiol（正在进行中）。

久原徹哉: 第80回日本畜産学会大会講演要旨. 187 (1988)

Tetsuya Kuhara：日本动物科学学会第 80 届年会摘要 187（1988）。