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Plasticity of blood vascular system in endocrine and exocrine glands

内分泌和外分泌腺血管系统的可塑性

基本信息

批准号：
62480094
负责人：
FUJITA Hisao
金额：
$ 4.1万
依托单位：
Osaka University Medical School
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

1) The morphological plasticity of thyroid blood capillaries in long-term low-iodine-diet (LID)-treated rats was studied. By SEM of the corrosion cast, it was clear that the blood capillaries in the basket-like network surrounding each follicle become heterogeneously dilated and show many buddings, branches, and an anastomoses. By TEM, the capillary endothelial cells from the long-term LID-treated rats became larger in volume of the cytoplasm with well-developed rough endoplasmic reticulum, Golgi apparatus and numerous vesicles. The sproutings and the fusion of the capillaries were often seen. The ^3H-thymidine autoradiography demonstrated that DNA-synthesizing endothelial cells, pericaplillary cells, and follicle epithelial cells were markedly increased in number after 2-3 weeks of LID feeding. The thyroid capillaries are flexible and changed in morphology by functional states of the gland.2) The three-dimensional architectures and the regional differences of the vascular system in the mucosa of teh hamster stomach were revealed by scanning electron microsoopy of corrosion casts. In the forestomach, the vascular network spreads two-dimensionally in a thin lamina propria. In the corpus and the antrum, the capillaries in the thick lamina propria are well developed, extending three-dimensionally along the gastric pits and glands. In the corpus, the submucosal arteries enter the lamina propria to become ascending capillaries, which project toward the top of the lamina propria and anastomose to create a capillary network beneath the mucosal epithelium. A subepithelial capillary is mcuh wider in diameter than an ascending capillary and is, therefore, a sinusoid capillary. Subepithelial capillaries join descending venules, which are less numerous than the ascending capillaries.

1)研究长期低碘饮食(LID)大鼠甲状腺毛细血管的形态可塑性。扫描电子显微镜观察发现，毛囊周围呈篮状网状结构的毛细血管呈不均匀扩张，可见多个芽突、分支和网状网状结构。经透射电子显微镜观察，长期LID组大鼠毛细血管内皮细胞胞浆体积增大，粗面内质网、高尔基体发达，囊泡较多。常可见毛细血管的发芽和融合。~3H-胸腺嘧啶核苷放射自显影显示，喂饲LID 2~3周后，内皮细胞、乳头周围细胞和毛囊上皮细胞合成DNA的数量明显增加。(2)腐蚀铸型的扫描电子显微镜显示了仓鼠胃粘膜血管系统的三维构筑和区域差异。在前胃，血管网以薄固有层的形式二维展开。在胃体和胃窦部，厚层固有层内的毛细血管发达，沿着胃小凹和胃腺三维延伸。在体部，粘膜下动脉进入固有层成为上升的毛细血管，这些上升的毛细血管向固有层的顶部伸出并相互吻合，在粘膜上皮下形成一个毛细血管网络。上皮下毛细血管的直径比上升毛细血管宽，因此是一种正弦毛细血管。上皮下毛细血管与下行小静脉相连，这些小静脉的数量比上升微静脉少。