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Plasticity of the blood vessels related to the secretory activity of glands

血管的可塑性与腺体的分泌活动有关

基本信息

批准号：
02670009
负责人：
FUJITA Hisao
金额：
$ 1.47万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670009/
关键词：
Thyroid Blood Capillary plasticity of Blood Vessels Secretory Activity gland Corroision Cast of Blood vessels Growth Factor Scanning Electron Microscopy 血管の発芽

项目摘要

In all the endocrine glands, the secretory materiais are released into the connective tissue space, and then enter tlie capillary lumen by passing throilgli the endothelial fenestrations. In the thyroid gland, the population density ind the nijmber of the endothelial fenestrations are changeable and flexible according to the secretory activity of the gland. Both tlie number and density are markedly increased in long-term heperfunctional state of the thyroid gland and decreased in long-term hypofunctional state.Three-dimensional aspects of tlie thyroid g)-and determined by scanning electron microscopy of corrosion casts show that each follicle of tile thyroid is sijrroiinded by a network of very frequently branclicd b-l-oo(I capillaries. The c, -ipillary network looks like a basket encapsulating the follicle in monkeys, dogs, rats and mice. In tlie hyperfunctional state, the capillaries in cacti basket are markedly dilated, and numerous sproutings and anastomoses with one another are observed, while in tlie hypofunctional state the capillaries covering each follicle become very narrow in diameter, and very poorly distributed as compared with those of normal and hyperfunctional animals.The sproutings and anastomoses of tlie blood capillaries in liyperfunctinil state of the thyroid gland is considered to be due to qxjantity of TSII, though its(letail. ed mechanism is not has not been solved. The fibrolasts, pericytes, and blood platelets might have a great role for tlie mitosis, growth and sporunting of the endothelial cell. I wish to emphasize that the microvascular system in tlie thyroid gland is flexible and changeable, , in(I shows a p-l-, isticity in tlirce-dimenstonil im, , igcs, distribution patterns, and endothelial morptiol-ogics, m, liich rcflects tIlC functional state of the gland.

所有内分泌腺的分泌物质都释放到结缔组织间隙，然后通过内皮细胞的开窗进入毛细血管腔。在甲状腺中，根据腺体的分泌活动，内皮细胞窗孔的数量和密度是可变的和灵活的。在长期的甲状腺功能亢进状态下，甲状腺滤泡的数量和密度均明显增加，而在长期的甲状腺功能减退状态下，甲状腺滤泡的数量和密度均明显减少。在猴子、狗、大鼠和小鼠中，c-ipillary网络看起来像一个包裹卵泡的篮子。在功能亢进状态下，仙人掌篮中的毛细血管显著扩张，并且观察到彼此之间的许多发芽和开花，而在功能减退状态下，覆盖每个毛囊的毛细血管的直径变得非常窄，与正常和机能亢进动物相比，分布极不均匀，认为甲状腺脂质过氧化状态下的毛细血管出芽和扩张”““是的，“他说。艾德的作用机理还没有得到解决。成纤维细胞、周细胞和血小板对内皮细胞的有丝分裂、生长和形成可能起重要作用。甲状腺微血管系统是灵活多变的，其分布方式和内皮细胞形态学反映了甲状腺的功能状态。