Quantitative assessment of Arterial Blood Flow Measurement by Digital Subtraction Angiography

数字减影血管造影对动脉血流测量的定量评估

• 批准号: 62480239
• 负责人: KOZUKA Takahiro
• 金额: $ 3.84万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480239/
• 关键词: DSA; Blood Flow; Transit Time; Vascular Volume; 大動脈冠動脈バイパスグラフト

The mean blood flow was measured with mean transit time and vascular volume by digital subtraction angiography(DSA). The angiographic equipment is DVI-II of phillips manufacture. Image series are aquired with a matrix 512 x 512 pixels at a frequency 30 frames/sec. Transit time of contrast medium is determined as the time between two time density curves(TDC) measured at a proximal and a distal site of the vessel. Back-ground corrected TDC is transformed to 300 points/sec by interpolation. The relation between digital densitometrically measured flow and actual flow was examined in a circulatory model ith continuous as well as pulsatile flow. Compared with peak method (appearance time is taken as peak point of TDC),peak 1/2 method(appearance time is taken when leading slope of TDC reaches half the maximum) and average method(first moment of TDC),cross-correlation method may have excellent applications. In cross-correlation method, good correlation was obtained in continuous flow(r=0.98) and in pulsatile flow(r=0.95).Theoretical best spatial resolution in our system is 0.15mm. To obtain this resolution,we employ selective injection of undiluted contrast media,tube potential of 70 kv and magnified image by 6.5 inch diameter image intensifier,based on experiment using the phantom,consisted of a lucite plate with drilled lumina ranging from 0.5mm to 7.0mm in diameter. The flow through aorto-coronary bypass graft was measured in man with our method.mean flow in 7 grafts(7 patients) with a mean body surface area of 1.63+-0.17m^2 amounted to 40.7+-11.5 ml/min. This value is consistent with the results of previous reports. By atrial pacing,graft frow increased significantly( p<0.01).

采用数字减影血管造影（DSA）测量平均血流量、平均通过时间和血管容积。血管造影设备为菲利普斯公司的DVI-II。以30帧/秒的频率获得具有512 x 512像素的矩阵的图像系列。造影剂的通过时间被确定为在血管的近端和远端部位处测量的两个时间密度曲线（TDC）之间的时间。背景校正TDC通过插值变换为300点/秒。在一个具有连续流和脉动流的循环模型中，研究了数字密度测量流量与实际流量之间的关系。与峰值法（以出现时间作为上止点的峰值点）、峰值1/2法（在上止点的前沿斜率达到最大值的一半时取出现时间）和平均法（上止点的一阶矩）相比，互相关法具有更好的应用前景。在互相关法中，连续流（r=0.98）和脉动流（r=0.95）的相关性较好，系统的理论最佳空间分辨率为0.15mm。为了获得这种分辨率，我们采用选择性注射未稀释的对比剂，管电位为70 μ m，用直径为6.5英寸的像增强器放大图像，根据使用体模的实验，体模由有机玻璃板组成，孔直径为0.5 - 7.0mm。用本方法测量了人体冠状动脉搭桥术后的血流量，7例平均体表面积为1.63 ± 0.17m^2的移植物平均血流量为40.7 ± 11.5ml/min，与文献报道的结果一致。心房起搏后移植物流量明显增加（P<0.01）。