Central nervous system effect of enflurane.

安氟醚的中枢神经系统作用。

• 批准号: 62480329
• 负责人: SAKABE Takefumi
• 金额: $ 3.33万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480329/
• 关键词: Enflurane anesthesia; Seizures; Brain metabolism; 血流; エンフルレン

Experiments were performed in cats and rats. In cats anesthetized with enflurane(2-5%), eeg seizures were not induced by hypocapnia(PaCO2;20mmHg), while with stimulation(tapping forelimb), seizures were induced either at normocapnia or hypocapnia when enflurane was above 3.5%. The stimulation required to induce seizures was dose-dependently decreased. Unilateral excision of cerebral cortex did not change EEG in the thalamus. Cortical EEG was not also affected by a destruction of ventrobasal complex(VB) in the thalamus and of the hippocampus. Stimulation required to induce seizures was not affected by a hippocampal destruction but was increased by a VB destruction. Somatosensory evoked petentials in the cortex and thalamus by an electrical stimulation of sciatic nerve during enflurane anesthesia were dose-dependently suppressed, and were not affected by cortical excision.Enflurane, on the other hand, increased threshold of electrically induced seizures and dose-dependently suppressed th … More e seizures induced by drugs (pentylenetetrazol, kainic acid, penicillin). Furthermore, deep enflurane anesthesia abolished the increase of glucose consumption in the VB, cerebral cortex, corpus callosum and internal capsule produced by intracortical injection of penicillin despite enflurane(4%) alone produced characteristic increase in these areas in rats. The increase in glucose consumption in the corpus callosum and hippocampal CA3 was not observed in cats even when seizures were induced by forelimb tapping. Local cerebral blood flow was markedly increased during 4% enflurane anesthesia, which was decreased by hypocapnia, possibly producing uncoupling between metabolism and flow.In summary, somatosensory stimulation induces seizures during deep enflurane anesthesia, while electrically or drug-induced seizures are suppressed, suggesting epileptogenic and antiepileptic properties of enflurane. The results also demonstrated the species difference in cerebral cortical and intercortical activities during enflurane anesthesia. Less

实验在猫和大鼠中进行。在用安氟醚（2-5%）麻醉的猫中，低碳酸血症（PaCO_2; 20 mmHg）不诱发EEG癫痫发作，而刺激（敲击前肢），当安氟醚高于3.5%时，在正常碳酸血症或低碳酸血症下诱发癫痫发作。诱导癫痫发作所需的刺激呈剂量依赖性降低。单侧大脑皮层切除不改变丘脑脑电图。皮质脑电图也没有受到丘脑和海马的ventrobasal复合体（VB）的破坏。诱导癫痫发作所需的刺激不受海马破坏的影响，但增加了VB破坏。在安氟醚麻醉期间，电刺激坐骨神经引起的皮层和丘脑体感诱发电位受到剂量依赖性抑制，而皮层切除不影响。另一方面，安氟醚增加电诱发癫痫发作的阈值，并剂量依赖性抑制皮层和丘脑体感诱发电位。 ...更多信息 e药物（戊四唑、红藻氨酸、青霉素）引起的癫痫发作。此外，深度安氟醚麻醉取消了皮质内注射青霉素产生的VB、大脑皮质、胼胝体和内囊中葡萄糖消耗的增加，尽管安氟醚（4%）单独在大鼠这些区域产生特征性增加。在猫胼胝体和海马CA 3区葡萄糖消耗的增加，即使当癫痫发作引起前肢轻敲。局部脑血流量显着增加，在4%的安氟醚麻醉，这是减少低碳酸血症，可能产生代谢和flow.In总结之间的解偶联，体感刺激诱导癫痫发作在深安氟醚麻醉，而电或药物诱导的癫痫发作被抑制，这表明癫痫和抗癫痫特性的安氟醚。结果还表明，在安氟醚麻醉期间，大脑皮层和皮层间活动存在种属差异。少

项目成果

Takefumi Sakabe: Anesthesia Analgesia.

坂部武文：麻醉镇痛。

Takefumi Sakabe: Anesthesiology.

坂部武文：麻醉学。

Sakabe,Takefumi: "Modification of drug-induced seizure activities by enflurane anesthesia." Anesthesiology.

Sakabe，Takefum​​i：“通过安氟烷麻醉改变药物诱发的癫痫发作活动。”

Kazuhiko,Nakakimura: Anesthesiology. 68. 777-782 (1988)

中木村和彦：麻醉学。

Takefumi,Sakabe: Anesthesia Analgesia.

Takefum​​i，Sakabe：麻醉镇痛。