Studies on the mechanism of thrombosis formation in hypoalbuminemia and hyperlipidemia.

低蛋白血症和高脂血症血栓形成机制的研究。

基本信息

  • 批准号:
    62480434
  • 负责人:
  • 金额:
    $ 4.35万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
  • 财政年份:
    1987
  • 资助国家:
    日本
  • 起止时间:
    1987 至 1988
  • 项目状态:
    已结题

项目摘要

Thrombotic diseases are increasing recently. Among the various dsisease states, thrombotic episodes have been known to associate frequently with nephrotic syndrome which is characterized by hyperlipidemia and hypoalbuminemia. However, mechanism by which thrombus can be formed in this syndrome remains to be clarified. To elucidate the mechanism of thrombus formation under hypoalbuminemia and hyperlipidemia, coagulation and fibrinolytic states were characterized in Nagase analbuminemia rats (NAR) which reveals the patological condtions similar to nephrotic syndrome; i.e.analubuminemia and hyperlipidemia.1. Anti human facotor Xa (FXa) activity was found in plasma of nar and Sprague-Dawrey rats (SDR), the value of which was found to be 2-3 times higher in nar than that in SDR. Although the plasma component responsible for the anti human F-Xa activity has not yet been fully identified, alpha2-macroglobulin may be possibly one of good candidates. Plasma levels of antithrombin III (at III) an … More d alpha2-plasmin inhibitor were higher in NAR than those in SDR.2. When endotoxin was administered to NAR and SDR, mortality was significantly higher in NAR than that in SDR (30 % vs 0 %, respectively). Based on the findings of the changes in coagulation and fibrinolysis of these experimental DIC animals, severer DIC was induced in NAR than in SDR.3. When thrombus was induced in the small mesenteric artery of rats by inserting the microglass pipette, thrombus was formed within 4-5 min of insertion in both animals. Thrombus thus formed gradually grew up in its size to dissociate from the glasspipette and vascular wall and flew away into circulation. Thrombus was disappeared in such a way within 3-4 min of the thrombus formation in SDR, whereas thrombus was disappeared at 12-15 min of the formation in NAR and the maximum size of thrombus was 3 times bigger in NAR than that in SDR.These findings suggested that NAR might be sensitive to the stimuli causing to the thrombus formation and , thus, hypoalbuminemia and hyperlipidemia per se might be the risk factors for the thrombus formation. Less
近年来血栓性疾病呈上升趋势。在各种疾病状态中,已知血栓性发作经常与肾病综合征相关,肾病综合征的特征是高脂血症和低白蛋白血症。然而,在这种综合征中血栓形成的机制仍有待阐明。为了阐明低白蛋白血症和高脂血症下血栓形成的机制,在长濑无白蛋白血症大鼠(NAR)中表征凝血和纤溶状态,其揭示了类似于肾病综合征的病理学条件;即无白蛋白血症和高脂血症。在nar和Sprague-Dawrey大鼠(SDR)血浆中发现抗人凝血因子Xa(FXa)活性,nar大鼠的FXa活性比SDR大鼠高2-3倍。虽然负责抗人F-Xa活性的血浆成分尚未完全确定,但α 2-巨球蛋白可能是良好的候选者之一。血浆抗凝血酶III(AT III)水平和 ...更多信息 d α 2-纤溶酶抑制剂在NAR组高于SDR组.当对NAR和SDR给予内毒素时,NAR的死亡率显著高于SDR(分别为30%和0%)。通过对上述实验性DIC动物凝血和纤溶指标的观察发现,NAR比SDR更易诱发DIC.当通过插入微玻璃移液管在大鼠的小肠系膜动脉中诱导血栓时,在两只动物中,血栓在插入后4-5分钟内形成。由此形成的血栓逐渐变大,从玻璃管和血管壁分离并飞到循环中。SDR在血栓形成后3-4 min内血栓即消失,而NAR在血栓形成后12-15 min内血栓即消失,其最大血栓体积是SDR的3倍。低白蛋白血症和高脂血症本身可能是血栓形成的危险因素。少

项目成果

期刊论文数量(47)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hiroaki,Okabe: "Further studies on the resolution of human mercapto- and nonmercaptoalbumin and on human serum albumin in the elderly by high performance liquid chromatography." Int. J. Peptide Protein Res.31. 435-442 (1988)
Hiroaki,Okabe:“通过高效液相色谱法对人巯基和非巯基白蛋白以及老年人血清白蛋白的分离进行进一步研究。”
  • DOI:
  • 发表时间:
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  • 影响因子:
    0
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  • 通讯作者:
Kenji,Okajima: "Characterization of fibrinolytic state by measuring stable crosslinked degradation products in disseminated intravascular coagulation" Acta Haematologica. (1989)
Kenji,Okajima:“通过测量弥散性血管内凝血中稳定的交联降解产物来表征纤溶状态”Acta Haematologica。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Kenji Okajima: IGAKU NO AYUKI. 142. 505-506 (1987)
冈岛健二:我的彩。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Masayasu Inoue: Biochem.Pharmacol.36. 2145-2150 (1987)
井上雅康:Biochem.Pharmacol.36。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Masayasu Inoue: Kidney International. 32. 198-203 (1987)
井上雅康:肾脏国际。
  • DOI:
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  • 影响因子:
    0
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OKABE Hiroaki其他文献

オッズに基づく二値回帰モデルの予測力改善指標
基于比值的二元回归模型预测力提升指数
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    OKABE Hiroaki;SHIMIZU Chikara;YAMAMOTO Maiko;KIKUCHI Rei;MINAMI Akiko;CHEN Yi-Fan;IMAI Hideyuki;MIZUTA Masahiro;CHEN Zhen;CHIBA Hitoshi;HUI Shu-Ping;林 賢一,江口 真透;林 賢一,江口 真透
  • 通讯作者:
    林 賢一,江口 真透
Determination of Serum 25-Hydroxyvitamin D<sub>3</sub> by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers
LC/MS/MS法测定札幌室内作业人员血清25-羟基维生素D<sub>3</sub>及其月变化
  • DOI:
    10.2116/analsci.18p193
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    1.6
  • 作者:
    OKABE Hiroaki;SHIMIZU Chikara;YAMAMOTO Maiko;KIKUCHI Rei;MINAMI Akiko;CHEN Yi-Fan;IMAI Hideyuki;MIZUTA Masahiro;CHEN Zhen;CHIBA Hitoshi;HUI Shu-Ping
  • 通讯作者:
    HUI Shu-Ping

OKABE Hiroaki的其他文献

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{{ truncateString('OKABE Hiroaki', 18)}}的其他基金

Research of analytical methods for infection test by capillary electrophoresis.
毛细管电泳感染检测分析方法研究。
  • 批准号:
    11672299
  • 财政年份:
    1999
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of analytical methods by capillary electophoresis for human fluids.
开发人体液体毛细管电泳分析方法。
  • 批准号:
    06672296
  • 财政年份:
    1994
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Evaluation Of Clinical Laboratory Test By Using Quartz Crystal Resonator
使用石英晶体谐振器进行临床实验室测试的评价
  • 批准号:
    04671437
  • 财政年份:
    1992
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
Proteolytic Measurement of Isoenzymes in Blood
血液中同工酶的蛋白水解测量
  • 批准号:
    01480506
  • 财政年份:
    1989
  • 资助金额:
    $ 4.35万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)

相似海外基金

Identity of hereditary cerebellar ataxia, peripheral neuropathy, and hypoalbuminemia
遗传性小脑共济失调、周围神经病和低蛋白血症的鉴别
  • 批准号:
    13670821
  • 财政年份:
    2001
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    $ 4.35万
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THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
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    6523903
  • 财政年份:
    2001
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    $ 4.35万
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THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
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  • 批准号:
    6650201
  • 财政年份:
    2001
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    $ 4.35万
  • 项目类别:
THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
透析低蛋白血症和同型半胱氨酸血症的治疗
  • 批准号:
    6225767
  • 财政年份:
    2001
  • 资助金额:
    $ 4.35万
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THERAPY IN DIALYSIS HYPOALBUMINEMIA AND HOMOCYSTEINEMIA
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  • 批准号:
    6781064
  • 财政年份:
    2001
  • 资助金额:
    $ 4.35万
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MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
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  • 批准号:
    2017102
  • 财政年份:
    1997
  • 资助金额:
    $ 4.35万
  • 项目类别:
MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
终末期肾病低蛋白血症的机制
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    6177498
  • 财政年份:
    1997
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    $ 4.35万
  • 项目类别:
MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
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    6381038
  • 财政年份:
    1997
  • 资助金额:
    $ 4.35万
  • 项目类别:
MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
终末期肾病低蛋白血症的机制
  • 批准号:
    2905827
  • 财政年份:
    1997
  • 资助金额:
    $ 4.35万
  • 项目类别:
MECHANISMS OF HYPOALBUMINEMIA IN ENDSTAGE RENAL DISEASE
终末期肾病低蛋白血症的机制
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    2713424
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    1997
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    $ 4.35万
  • 项目类别:
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