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The origin and pathology of the adhesive otitis media and relation with middle ear cholesteatoma

粘连性中耳炎的起源、病理及其与中耳胆脂瘤的关系

基本信息

批准号：
63480387
负责人：
HONDA Yoshio
金额：
$ 3.71万
依托单位：
The Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-63480387/
关键词：
Adhesive otitis media Sequelae of secretory otitis Tensa cholesteatoma Otitis induced perceptive deafness Experimental adhesive otitis Relation between adhesive otitis and cholesteatoma 癒着性中耳炎と真珠腫の関係緊張部型真珠腫中耳真珠腫の成因癒着性中耳炎の病態実験的真珠腫 /

项目摘要

In order to examine the pathogenesis of adhesive otitis and the relationship between adhesive otitis and cholesteatoma, following researches were conducted.1. clinical examinations 2. morphological observations of the animal tympanic membrane on the experimental otitis 3. morphology of the tympanic membrane in cases of adhesive otitis and cholesteatoma 4. study of human temporal bone 5. mechanism of sensory deafness in adhesive otitis 6. experimental otitis. Results are follows.1. Adhesive otitis occurs as a sequela of infant persistent secretory otitis. Fibrous layers of the tympanic membrane are dissolved at the initial stage, then the tympanic membrane is gradually depressed by negative pressure in the middle ear. For the occurrence of the adherent phenomenon, some bacterial infection is considered to be necessary.2. The transition from secretory otitis to adhesive otitis is made at early stage of childhood.3. The transformation from adhesive otitis to tensa cholesteatoma is considered to be made in childhood too.4. The situation of the tympanic orifice of the Eustachian tube is not only serious for the tympanoplasty except some partial cases.5. Even in case of complete closure on the Eustachian tube, the tympanic membrane is not only adhered to the promontory. The tympanic membrane that the middle layer is extremely thick is too hard to adherent.6. Perceptive deafness from adhesive otitis occurs through the round window membrane. The granulation tissure of the round window niche are considered to injure the inner ear function.7. To make the animal model of the adhesive otitis is quite difficult, this matter will be future problem.

为探讨粘连性中耳炎的发病机制及与中耳炎的关系，进行了以下研究.临床检查2.实验性中耳炎动物鼓膜形态学观察3.粘连性中耳炎和中耳炎的鼓膜形态学4.人颞骨研究5.粘连性中耳炎感觉性耳聋的机制6.实验性耳炎研究结果如下：1.粘连性中耳炎是婴儿持续性分泌性中耳炎的后遗症。鼓膜的纤维层在初始阶段溶解，然后鼓膜逐渐被中耳的负压压低。对于粘连现象的发生，认为一定的细菌感染是必要的.从分泌性中耳炎向粘连性中耳炎的转变发生在儿童早期.从粘连性中耳炎到张力性中耳瘤的转变也被认为是在儿童时期发生的。除部分病例外，咽鼓管鼓口的情况不仅对鼓膜成形术来说很严重。即使在咽鼓管完全关闭的情况下，鼓膜也不仅粘附在海角上。中间层极厚的鼓膜太硬，难以粘附。6.粘连性耳炎引起的感知性耳聋是通过圆窗膜发生的。圆窗龛内的肉芽组织可考虑为内耳功能损害.粘连性中耳炎的动物模型制作难度较大，是今后的研究课题。