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Studies of proliferating and ingibiting factors to the transformation from infant secretory otitis media to cholesteatoma

婴儿分泌性中耳炎向胆脂瘤转化的增殖及影响因素研究

基本信息

批准号：
60480385
负责人：
HONDA Yoshio
金额：
$ 4.1万
依托单位：
The Jikei University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1986
项目状态：
已结题

项目摘要

The acquired cholesteatoma originats from sequela of chronic infant secretory otitis media(SOM) and is diveded into two categories, that is flaccida type and tenza type. The purpose of the studies are that elucidate the factors which promote or prevent the development of cholesteatomaNext studies were performed to accomplish this aim. Detailed observation for the advance of cholesteatoma matrix during surgeries, long term following up to the patients with SOM, morphological study of inflammatory temporal bone especially of sclerotic mastoid.Prosperity and decay of secretory glands of mucose membrane of the middle ear and mastoid, culture study of epedermal cells and matrix of cholesteatoma, besides study of prowth factors to the epidermal cell, ultrastructure of the ear drum of SOM.As the results of these studies, the promoters of progression from secretory otitis media(SOM) to cholesteatoma can be explained as follows. Deficiency of tubal function, suppressed air cell system of mastoid and blockage of aeration to the mastoid. Besides, continuance of slight inflammation, negative pressure, growth factors to the epidermis of tympanic membrane in the attic are promoting factors to cholesteatoma. Further, disappearance of fibers in pars tneza and adhesion of tympanic membrane are important mechanism to promote the developmnet of tenza cholesteatoma.On the other hand, the essential conditions for arresting the development to cholesteatoma are as follows, early improvement of tubal function especially at the age of childhood, re-pneumatization of suppressed mastoid, occurrence of tympanic perforation and prevention of adhesion. From these consequences insertion of ventilation tube to the chronic secretory otitis media is ideal procedure.

获得性中耳瘤起源于婴儿慢性分泌性中耳炎（SOM）的后遗症，分为弛缓型和紧张型。这些研究的目的是阐明促进或阻止中耳炎发展的因素。术中详细观察中耳乳突瘤基质的进展情况，对SOM患者进行长期随访，对炎性颞骨尤其是乳突炎性颞骨进行形态学观察，对中耳乳突粘膜分泌腺的繁荣和衰退进行观察，对中耳乳突瘤上皮细胞和基质进行培养，并对表皮细胞的生长因子进行研究，作为这些研究的结果，分泌性中耳炎（SOM）发展为中耳乳突瘤的促进因素可以解释如下。输卵管功能障碍，乳突气房系统抑制，乳突通气障碍。此外，轻度炎症的持续、负压、生长因子对上鼓室鼓膜表皮的影响也是中耳炎的促进因素。鼓室部纤维消失和鼓膜粘连是促进Tenza型中耳炎发展的重要机制，而早期改善输卵管功能，特别是在儿童期，使受抑制的乳突再通，发生鼓膜穿孔和防止粘连，是阻止其发展为Tenza型中耳炎的必要条件。从这些后果插入通气管的慢性分泌性中耳炎是理想的程序。