A study on a development of a retinal lattice degeneration

视网膜格子变性发展的研究

• 批准号: 03807117
• 负责人: SAKATA Hiroshi
• 金额: $ 1.15万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-03807117/
• 关键词: Superior oblique muscle; Lattice degeneration; 上斜筋牽引

1. Materials and MethodsA tendon of superior oblique muscle (SOM) was exposed, and looped by a 4-0 silk thread in a newborn rabbit. The silk thread was connected with a 2-0 nylon from a handmade vibrator which worked by a magnetic morter. A contraction of SOM forced on hour everyday during a various period (1 to 3 months). An eye ball was enucleated after a non-stimulated period (2 to 3 months), and macroscopically or microscopically observed.2. Result(1) macroscopic findings : A retina below the insertion of SOM to a sclera showed a slightly diffuse discoloration, compared to a control, at 2 to 3 months.(2) microscopic findings : A choroid adjacent to the insertion of SOM to a sclera had a strong edema at 2 months, and a slight atrophy at 3 months. A sclera was thickened, and the collagen fibers was irregularly arranged. But an architecture of the retina was normal at all the time.3. A further perspectionBased upon histological changes in the present study and a known physiological role of a choroid in a maintenance of retinal architecture and function, there is a high possibility that a retina may, in the future, develop a histological change like a lattice degeneration or something in these rabbit in which SOM was forced.

1.材料与方法在新生家兔上暴露上级斜肌肌腱，用4-0丝线环扎。丝线与来自手工振动器的2-0尼龙连接，该振动器由磁性研钵工作。在不同的时期（1至3个月），SOM每天被迫收缩1小时。在非刺激期（2至3个月）后摘除眼球，并进行肉眼或显微镜检查。结果（1）肉眼观察结果：与对照组相比，在2至3个月时，SOM巩膜附着点以下的视网膜显示轻微弥漫性变色。(2)显微镜检查结果：2个月时，与SOM巩膜附着点相邻的脉络膜出现严重水肿，3个月时出现轻微萎缩。巩膜增厚，胶原纤维排列不规则。但视网膜结构始终正常。基于本研究中的组织学变化和脉络膜在维持视网膜结构和功能中的已知生理作用，在这些SOM被迫的兔子中，视网膜将来可能会发生组织学变化，如晶格变性或其他。

项目成果

坂田広志・調枝寛治: "網膜格子状変性の成因についての一試案" 眼科臨床医報.85. 1760-1760 (1991)

Hiroshi Sakata 和 Hiroharu Choeda：“视网膜格子变性原因的初步建议”眼科临床杂志.85 1760-1760（1991）。

Hiroshi Sakata: "A tentative plan about development of retinal lattice degeneration" Japanese Review of Clinical Ophthalmdogy. Vol.85. 1760-1760 (1991)

Hiroshi Sakata：“关于视网膜格子变性发展的初步计划”日本临床眼科评论。