Genome-wide association study of lattice degeneration of the retina using 23,465 microsatellite markers

使用 23,465 个微卫星标记进行视网膜晶格变性的全基因组关联研究

• 批准号: 20592052
• 负责人: ITO Norihiko
• 金额: $ 3万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592052/
• 关键词: ゲノムワイド相関解析; マイクロサテライト; SNP; 網膜格子状変性; ゲノムワイド

To identify susceptibility genes for lattice degeneration of the retina, we performed a genome-wide association study using a comprehensive set 23,465 microsatellite markers in 574 Japanese cases and 608 controls, and identified the disease-associated gene for the disease.

为了确定视网膜格子状变性的易感基因，我们在574例日本病例和608例对照中使用全面的23，465个微卫星标记进行了全基因组关联研究，并确定了该疾病的疾病相关基因。

项目成果

Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease.

• DOI: 10.2147/opth.s1858
• 发表时间: 2008-06
• 期刊: Clinical ophthalmology (Auckland, N.Z.)
• 作者: Hayashi T;Ishioka M;Ito N;Kato Y;Nakagawa H;Hatano H;Mizuki N
• 通讯作者: Mizuki N

Microsatellite analysis of the GLC1B locus on chromosome 2 points to NCK2 as a new candidate gene for normal tension glaucoma

• DOI: 10.1136/bjo.2008.139980
• 发表时间: 2008-09-01
• 期刊: BRITISH JOURNAL OF OPHTHALMOLOGY
• 影响因子: 4.1
• 作者: Akiyama, M.;Yatsu, K.;Mizuki, N.
• 通讯作者: Mizuki, N.

Four-digit allele genotyping of HLA-A and HLA-B genes in Japanese patients with Behcet's disease.

日本白塞氏病患者 HLA-A 和 HLA-B 基因的四位等位基因基因分型。

• 发表时间: 2008
• 期刊: Nippon Ganka Gakkai Zasshi 112(5)
• 作者: Kamiishi T;Itoh Y;Meguro A;Nishida T;Sasaki S;Nanba K;Ohno S;Inoko H;Mizuki N.
• 通讯作者: Mizuki N.

Rac1 mediates phorbol 12-myristate 13-acetate-induced migration of glioblastotma cells via paxillin

Rac1通过桩蛋白介导佛波醇12-肉豆蔻酸酯13-乙酸酯诱导的胶质母细胞瘤细胞迁移

• 发表时间: 2008
• 期刊: Oncol Rep 20
• 作者: Kirino Y;Takeno M;Watanabe R;Murakami S;Kobayashi M;Ideguchi H;Ihata A;Ohno S;Ueda A;Mizuki N;Ishigatsubo Y.;Meguro A;Shibuya E;Akiyama M;Nomura N
• 通讯作者: Nomura N

Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis.

• DOI: 10.2147/opth.s4727
• 发表时间: 2009
• 期刊: Clinical ophthalmology (Auckland, N.Z.)
• 作者: Kamio M;Meguro A;Ota M;Nomura N;Kashiwagi K;Mabuchi F;Iijima H;Kawase K;Yamamoto T;Nakamura M;Negi A;Sagara T;Nishida T;Inatani M;Tanihara H;Aihara M;Araie M;Fukuchi T;Abe H;Higashide T;Sugiyama K;Kanamoto T;Kiuchi Y;Iwase A;Ohno S;Inoko H;Mizuki N
• 通讯作者: Mizuki N