Identification of differential regulator of mitosis and meiosis
有丝分裂和减数分裂差异调节因子的鉴定
基本信息
- 批准号:03833006
- 负责人:
- 金额:$ 1.22万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1991
- 资助国家:日本
- 起止时间:1991 至 1992
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Involvement of the cdc2, cdc13 and cdc25 genes in meiosis in Schizosaccharomyces pombe was investigated. Using temperature- sensitive mutants and three different conditions to induce meiosis, it was found that, in contrast to the previous reports, all of these genes are required for both meiosis I and meiosis II. The cdc2 gene, which is known to be essential for the initiation of both M-phase and S-phase in mitosis, is also required for premeiotic DNA synthesis.Expression of the cdc25 and cdc13 genes was induced in concomitant with premeiotic DNA synthesis, reaching a sharp peak before the first nuclear division. Expression of cdc22 was also induced but with a peak before premeiotic DNA synthesis. The induction of cdc25 and cdc13 was hampered if DNA synthesis was inhibited, but that of cdc22 was not. The mei4 gene that is essential for meiosis is required for the induction of cdc13 and cdc25. Dependency on DNA synthesis of the induction of genes that are important for activation of p34^<cdc2> kinase has not been observed in mitosis and appears to be unique to meiosis. This may constitute a mechanism of checkpoint control in meiosis.
研究了cdc2、cdc13和cdc25基因在粟酒裂殖酵母减数分裂中的作用。使用温度敏感突变体和三种不同条件诱导减数分裂,发现与以前的报道相反,所有这些基因都是减数分裂I和减数分裂II所需的。cdc25和cdc13基因的表达与减数分裂前的DNA合成同步,在第一次核分裂前达到高峰。cdc22的表达也被诱导,但在减数分裂前DNA合成前有一个高峰。如果DNA合成受到抑制,则cdc25和cdc13的诱导受到阻碍,但cdc22的诱导没有受到抑制。减数分裂所必需的mei4基因是诱导cdc13和cdc25所必需的。依赖于DNA的合成,对p34激酶的激活起重要作用的基因的诱导<cdc2>在有丝分裂中尚未观察到,似乎是减数分裂所特有的。这可能是减数分裂检查点控制的一种机制。
项目成果
期刊论文数量(24)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A.SUGIMOTO: "Schizosaccharomyces pombe stell^+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development" Genes and Development. 5. 1990-1999 (1991)
A.SUGIMOTO:“粟酒裂殖酵母编码具有 HMG 基序的转录因子,该基序是性发育的关键调节因子”《基因与发育》。
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- 影响因子:0
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- 通讯作者:
J.-F.Brunet: "Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening" Science. 252. 856-859 (1991)
J.-F.Brunet:“通过基于 PCR 的差异筛选鉴定海兔感觉神经元特异性肽”《科学》。
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- 影响因子:0
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- 通讯作者:
J.-F. Brunet: "Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening" Science. 252. 856-859 (1991)
J.-F。
- DOI:
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- 影响因子:0
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- 通讯作者:
J.ーF.Brunet: "Identification of a peptide specific for Aplysia sensory neurons by PCRーbased differential screening." Science. 252. 856-859 (1991)
J.-F.Brunet:“通过基于 PCR 的差异筛选鉴定海兔感觉神经元特异性肽。” 252. 856-859 (1991)。
- DOI:
- 发表时间:
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- 影响因子:0
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Y. Iino: "S.pombe pacl^+, whose overexpression inhibits sexual development, encodes a ribonuclease III-like RNase" EMBO Journal. 10. 221-226 (1991)
Y. Iino:“S.pombe pacl^,其过度表达抑制性发育,编码核糖核酸酶 III 样 RNase”EMBO 杂志。
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IINO Yuichi其他文献
Identification of genes involved in the pheromone signaling that regulates olfactory plasticity
鉴定参与调节嗅觉可塑性的信息素信号传导的基因
- DOI:
- 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
TORIYABE Hiroshi;YAMADA Koji;SAWAMURA Yoshiyuki;IINO Yuichi - 通讯作者:
IINO Yuichi
EFFECT OF INITIAL IMPERFECTION ON LOCAL BUCKLING BEHAVIOR OF SQUARE HOLLOW SECTION MEMBER
初始缺陷对方形空心截面构件局部屈曲行为的影响
- DOI:
10.3130/aijs.81.893 - 发表时间:
2016 - 期刊:
- 影响因子:0
- 作者:
TORIYABE Hiroshi;YAMADA Koji;SAWAMURA Yoshiyuki;IINO Yuichi;佐藤公亮,五十嵐規矩夫 - 通讯作者:
佐藤公亮,五十嵐規矩夫
IINO Yuichi的其他文献
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{{ truncateString('IINO Yuichi', 18)}}的其他基金
A comprehensive study of the molecular mechanisms of associative learning by a behavioral genetic approach.
通过行为遗传学方法全面研究联想学习的分子机制。
- 批准号:
21370002 - 财政年份:2009
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Study of the functions of the Ras-MAPK pathway and the insulin pathway in neural plasticity of C. elegans
Ras-MAPK通路和胰岛素通路在秀丽隐杆线虫神经可塑性中的作用研究
- 批准号:
15370071 - 财政年份:2003
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional study of the Ras-MAP kinase pathway in the nervous system
神经系统 Ras-MAP 激酶通路的功能研究
- 批准号:
13480224 - 财政年份:2001
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Elucidation of The Molecular Mechanims of Chemotaxis and Its Plasticity in the Nematode Caenorhabditis elegans
秀丽隐杆线虫趋化性及其可塑性分子机制的阐明
- 批准号:
11680672 - 财政年份:1999
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Analysis of estrogen-induced genes in breast cancer
乳腺癌雌激素诱导基因分析
- 批准号:
06454359 - 财政年份:1995
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Systematic Search for the Genes that Program Sex Behavior in Caenorhabditis elegans
系统性搜索秀丽隐杆线虫性行为基因
- 批准号:
07808093 - 财政年份:1995
- 资助金额:
$ 1.22万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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