权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Is metabolic rate depression (MRD) a life prolonging strategy in long-lived Arctica islandica on a latitudinal climate gradient? Environmental constraints and evolutionary adaptation in the Ocean quahog

代谢率降低（MRD）是纬度气候梯度上长寿的北极岛的一种延长寿命的策略吗？

基本信息

批准号：
44089445
负责人：
Privatdozentin Dr. Doris Abele (†)
金额：
--
依托单位：
Alfred-Wegener-Institut (AWI) Helmholtz-Zentrum für Polar- und Meeresforschung
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2007
资助国家：
德国
起止时间：
2006-12-31 至 2011-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/44089445?language=en
关键词：
metabolic rate depression MRD life

项目摘要

The ocean quahog Arctica islandica is an arctic boreal marine mud clam with a wide ranging distribution on the Northern hemisphere, spanning habitats with different climate regimes. It is also the longest-lived of all bivalve and molluscan species, animals >100 yrs are common in many populations, and reported maximum live span is 374 yrs (Iceland population). However, such venerable age has not yet been reported for all populations. Based on the Free Radical-Rate of Living theory by Pearl (1928) and Harman (1956) we assume that random bouts of self-induced metabolic rate depression (MRD) will lower generation rates of reactive oxygen species. This may be an energy saving and life prolonging strategy in the ocean quahog. Further, we assume that cold climate will favour MRD behaviour and raise life expectancy in cold-boreal compared to temperate populations.Here we propose to study MRD behaviour in two A. islandica populations from different temperature regimes (Iceland and North Sea) in an age dependent manner. We will compare postmitotic neuronal and proliferating tissues (gill, mantle, adductor muscle) of differently aged individuals from the two populations with respect to energy metabolism, antioxidant capacities, oxidative stress indicators and lipofuscin accumulation. Physiological age and stress markers will be related to MRD frequency and duration in both populations. Moreover, we propose to investigate the involvement of an NO signal in MRD during self-induced hypoxic/anoxic exposure of the quahog.

北极圆蛤是一种北极北海泥蛤，广泛分布于北半球，跨越不同气候条件的栖息地。它也是所有双壳类和软体动物物种中寿命最长的，>100 岁的动物在许多种群中很常见，据报道最大寿命为 374 岁（冰岛种群）。然而，尚未报道所有人群都有如此可敬的年龄。根据 Pearl (1928) 和 Harman (1956) 的自由基生存率理论，我们假设随机发作的自我诱发的代谢率降低 (MRD) 会降低活性氧的生成率。这可能是海洋斑驴的一种节能和延长寿命的策略。此外，我们假设与温带种群相比，寒冷气候将有利于寒带种群的 MRD 行为并提高预期寿命。在这里，我们建议以年龄依赖的方式研究来自不同温度状况（冰岛和北海）的两个 A. islandica 种群的 MRD 行为。我们将比较两个种群不同年龄个体的有丝分裂后神经元和增殖组织（鳃、外套膜、内收肌）的能量代谢、抗氧化能力、氧化应激指标和脂褐质积累。生理年龄和压力标记将与两个人群的 MRD 频率和持续时间相关。此外，我们建议研究在斑驴自身诱导的缺氧/缺氧暴露期间，NO 信号在 MRD 中的参与情况。